Q7TSC3

PR
Gene name
Nek5
Protein name
Serine/threonine-protein kinase Nek5
Names
Never in mitosis A-related kinase 5, NimA-related protein kinase 5
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:330721
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

253-450 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

142-165 (Activation loop from InterPro)

Target domain

4-255 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q7TSC3

Entry ID Method Resolution Chain Position Source
AF-Q7TSC3-F1 Predicted AlphaFoldDB

50 variants for Q7TSC3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388968299 4 F>L No EVA
rs3388929188 4 F>L No EVA
rs246397033 14 T>S No EVA
rs3388971661 36 S>N No EVA
rs49017218 49 I>V No EVA
rs3388945693 54 M>T No EVA
rs3388971595 131 F>Y No EVA
rs3388971628 142 G>V No EVA
rs3388972682 143 D>E No EVA
rs3388971630 146 T>R No EVA
rs50885579 156 L>F No EVA
rs3388978654 159 T>I No EVA
rs3388975375 168 S>F No EVA
rs3388978623 178 N>S No EVA
rs3398986351 200 F>Y No EVA
rs3388971601 230 S>Y No EVA
rs3388945778 233 P>H No EVA
rs51664224 246 V>I No EVA
rs3388972681 247 T>M No EVA
rs228336059 276 A>T No EVA
rs3388975524 303 F>Y No EVA
rs46397777 312 V>M No EVA
rs230479024 319 R>H No EVA
rs243700409 330 G>R No EVA
rs3388962086 343 Q>L No EVA
rs3388929128 371 D>V No EVA
rs3388945774 379 M>T No EVA
rs3388967357 426 E>G No EVA
rs236191685 445 C>F No EVA
rs3388945690 450 E>V No EVA
rs3388971623 453 F>V No EVA
rs3388975067 455 D>Y No EVA
rs213723868 459 A>T No EVA
rs246092703 469 A>V No EVA
rs226978258 475 R>Q No EVA
rs219514541 479 M>T No EVA
rs3397954703 493 G>C No EVA
rs227346457 499 E>A No EVA
rs47040350 511 D>E No EVA
rs235569317 536 T>P No EVA
rs50517636 557 I>N No EVA
rs50568545 565 E>K No EVA
rs3388971604 566 P>A No EVA
rs47584122 568 S>W No EVA
rs3388956191 574 K>N No EVA
rs3388956137 595 A>G No EVA
rs50709576 600 A>T No EVA
rs241010016 600 A>V No EVA
rs220788341 616 K>E No EVA
rs261099259 620 N>H No EVA

No associated diseases with Q7TSC3

3 regional properties for Q7TSC3

Type Name Position InterPro Accession
domain Protein kinase domain 4 - 255 IPR000719
active_site Serine/threonine-protein kinase, active site 120 - 132 IPR008271
binding_site Protein kinase, ATP binding site 10 - 33 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

3 GO annotations of biological process

Name Definition
positive regulation of cysteine-type endopeptidase activity Any process that activates or increases the frequency, rate or extent of cysteine-type endopeptidase activity.
positive regulation of striated muscle cell differentiation Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation.
protein phosphorylation The process of introducing a phosphate group on to a protein.

9 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P51957 NEK4 Serine/threonine-protein kinase Nek4 Homo sapiens (Human) PR
Q8NE28 STKLD1 Serine/threonine kinase-like domain-containing protein STKLD1 Homo sapiens (Human) PR
Q6P3R8 NEK5 Serine/threonine-protein kinase Nek5 Homo sapiens (Human) PR
Q8K1R7 Nek9 Serine/threonine-protein kinase Nek9 Mus musculus (Mouse) SS
Q10GB1 NEK1 Serine/threonine-protein kinase Nek1 Oryza sativa subsp japonica (Rice) PR
Q6ZEZ5 NEK3 Serine/threonine-protein kinase Nek3 Oryza sativa subsp japonica (Rice) PR
Q8RXT4 NEK4 Serine/threonine-protein kinase Nek4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LT35 NEK6 Serine/threonine-protein kinase Nek6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SLI2 NEK1 Serine/threonine-protein kinase Nek1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MDNFHLIKII GEGTFGKVYL AKDKSESSHC VIKEISLTKE KEASKNEVIL LARMEHPNIV
70 80 90 100 110 120
TFFSSFQENG RLFIVMEYCD GGDLMQRIQR QRGVMFSEDQ ILCWFVQISL GLKHIHDRKI
130 140 150 160 170 180
LHRDIKSQNI FLSKNGMVAK LGDFGTARTL NDSMELAQTC AGTPYYLSPE ICQNRPYNNK
190 200 210 220 230 240
TDIWSLGCVL YELCTLKHPF ESNNFHHLVL KICQGRVAPI SPHFSRDLQS LIPQLFRVSP
250 260 270 280 290 300
QDRPSVTSLL KRPFLETLIA RSLYPEVCSR RIQSHAHMEN MAIGPTACWR VSPWSAAYLQ
310 320 330 340 350 360
RKFEAQQYKL KVERQLGLRP SSVEPHPNEG EKLQSHWEET KFQELQYRKN KMKDQEYWKQ
370 380 390 400 410 420
LEEIRQQYHN DMKEIKKKMG RELKRVVKFE ISLDKCISEE DTVQENEAVD KLNATLSFED
430 440 450 460 470 480
GTKFQEHRCK EEHEDYTDRA FEELCGPEAE GFFQDVIAAE NRRQWDAGAP HTLLRIMAMA
490 500 510 520 530 540
DVTSTCPTMP DDGQVIVMEG SVENGKQWWL DVPGTPCALA AECACSGSLS ASKGETVMIK
550 560 570 580 590 600
PQLPKEDQEK VEIATGIMVD DEQLEPGSDE DDIKFEESED ELRSEIIESL EKLAASTEEA
610 620
EQAPSSSKNA EEPGEKEKTN LPVKKLQ