Q8R3S6
PR
Gene name |
Exoc1 (Sec3, Sec3l1) |
Protein name |
Exocyst complex component 1 |
Names |
Exocyst complex component Sec3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:69940 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8R3S6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8R3S6-F1 | Predicted | AlphaFoldDB |
30 variants for Q8R3S6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs13464259 | 8 | L>P | No | EVA | |
| rs3388765324 | 34 | K>E | No | EVA | |
| rs3395718517 | 54 | K>N | No | EVA | |
| rs3388749448 | 73 | R>L | No | EVA | |
| rs3388767768 | 92 | L>V | No | EVA | |
| rs3388767959 | 109 | N>K | No | EVA | |
| rs3388760907 | 126 | K>I | No | EVA | |
| rs3388760858 | 159 | E>* | No | EVA | |
| rs3395092524 | 252 | I>V | No | EVA | |
| rs3388760890 | 313 | Q>* | No | EVA | |
| rs3388751976 | 320 | R>H | No | EVA | |
| rs3388755851 | 322 | G>D | No | EVA | |
| rs236776115 | 329 | V>I | No | EVA | |
| rs3388749442 | 365 | T>A | No | EVA | |
| rs3388760823 | 368 | Q>E | No | EVA | |
| rs1134396051 | 380 | P>T | No | EVA | |
| rs3388751975 | 400 | Y>F | No | EVA | |
| rs3388767451 | 409 | N>K | No | EVA | |
| rs3388752007 | 427 | E>G | No | EVA | |
| rs3388767954 | 436 | T>A | No | EVA | |
| rs3388767746 | 457 | T>I | No | EVA | |
| rs3388765286 | 525 | L>R | No | EVA | |
| rs3388767835 | 531 | D>N | No | EVA | |
| rs3388760519 | 556 | D>Y | No | EVA | |
| rs31555950 | 561 | L>S | No | EVA | |
| rs3388749482 | 584 | I>V | No | EVA | |
| rs3388760893 | 628 | P>S | No | EVA | |
| rs3395530236 | 661 | V>L | No | EVA | |
| rs3395603867 | 662 | K>T | No | EVA | |
| rs3388774044 | 702 | Y>F | No | EVA |
No associated diseases with Q8R3S6
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic side of apical plasma membrane | The side (leaflet) of the apical region of the plasma membrane that faces the cytoplasm. |
| exocyst | A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. |
| Flemming body | A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| phosphatidylinositol-4,5-bisphosphate binding | Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| embryo implantation | Attachment of the blastocyst to the uterine lining. |
| exocytosis | A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. |
| Golgi to plasma membrane transport | The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis. |
| membrane fission | A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes. |
| mitotic cytokinesis | A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. |
| phosphatidylinositol-mediated signaling | The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
| positive regulation of protein secretion | Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell. |
| protein transport | The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| vesicle docking involved in exocytosis | The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. |
| vesicle tethering involved in exocytosis | The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTAIKHALQR | DIFTPNDERL | LSIVNVCKAG | KKKKNCFLCA | TVTTERPVQV | KVVKVKKSDK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GDFYKRQIAW | ALRDLAVVDA | KDAIKENPEF | DLHFEKVYKW | VASSTAEKNA | FISCIWKLNQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RYLRKKIDFV | NVSSQLLEES | VPSGENQSVA | GGDEEAVDEY | QELNAREEQD | IEIMMEGCEC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AISNAEAFAE | KLSRELQVLD | GANIQSIMAS | EKQVNTLMQL | LDEALTEVDQ | IELKLSSYEE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MLQSVKEQMD | QISESNHLIH | LSNTNNVKLL | SEIEFLVNHM | DLAKGHIKAL | QEGDLVSSRG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IEACTNAADA | LLQCMNVALR | PGHDMLLAVK | QQQQRFSDLR | EHFARRLASH | LNNVFVQQGH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DQSSTLAQHS | VELTLPNHHP | FHRDLLRYAK | LMEWLKSTDY | GKYEGLTKNY | MDYLSRLYER |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EIKDFFEVAK | MKMTGTSKES | KKFATLPRKE | SAVKQETESL | HGSSGKLTGS | TSSLNKLSVQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SSGSRRSQSS | SLLDMGNMSA | SDLDVADRTK | FDKIFEQVLS | ELEPLCLAEQ | DFISKFFKLQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QHQNMSASMT | EAEDLDGGSL | LRQHSSGTLL | PVSSEKDMIR | QMMIKIFRCI | EPELNNLIAL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| GDKVDSFNSL | YMLVKMSHHV | WTAQNVDPAS | FLSTTLGNVL | VTVKRNFDKC | ISNQIRQMEE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VKISKKSKVG | ILPFVAEFEE | FAGLAESIFK | NAERRGDLDK | AYTKLIRGVF | INVEKVANES |
| 730 | 740 | 750 | 760 | 770 | 780 |
| QKTPRDVVMM | ENFHHIFATL | SRLKISCLEA | EKKEAKQKYT | DHLQSYVIYS | LGQPLEKLNH |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FFEGVEARVA | QGIREEEVSY | QLAFNKQELR | KVIKEYPGKE | VKKGLDNLYK | KVDKHLCEEE |
| 850 | 860 | 870 | 880 | 890 | |
| NLLQVVWHSM | QDEFIRQYKH | FEGLIARCYP | GSGVTMEFTI | QDILDYCSSI | AQSH |