Q8R3C0
Gene name |
Mcmbp |
Protein name |
Mini-chromosome maintenance complex-binding protein |
Names |
MCM-BP, MCM-binding protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:210711 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8R3C0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8R3C0-F1 | Predicted | AlphaFoldDB |
34 variants for Q8R3C0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3398136262 | 19 | F>L | No | EVA | |
| rs3388957989 | 60 | L>P | No | EVA | |
| rs3388908081 | 64 | S>T | No | EVA | |
| rs3388951335 | 87 | T>I | No | EVA | |
| rs246555909 | 105 | V>I | No | EVA | |
| rs3388925232 | 116 | L>M | No | EVA | |
| rs3388946497 | 121 | S>P | No | EVA | |
| rs3388951527 | 153 | V>A | No | EVA | |
| rs3388949439 | 156 | S>* | No | EVA | |
| rs3388931460 | 156 | S>P | No | EVA | |
| rs3388925172 | 172 | E>K | No | EVA | |
| rs50108887 | 186 | P>S | No | EVA | |
| rs3388955090 | 284 | P>H | No | EVA | |
| rs250327312 | 291 | A>G | No | EVA | |
| rs3388954590 | 310 | I>N | No | EVA | |
| rs3388946473 | 331 | S>R | No | EVA | |
| rs3388955947 | 413 | L>H | No | EVA | |
| rs3388955947 | 413 | L>P | No | EVA | |
| rs3388925238 | 417 | S>F | No | EVA | |
| rs3388925147 | 459 | D>V | No | EVA | |
| rs250452859 | 462 | L>V | No | EVA | |
| rs223447804 | 471 | P>A | No | EVA | |
| rs3398123731 | 475 | N>K | No | EVA | |
| rs3398586586 | 480 | S>G | No | EVA | |
| rs3388955935 | 499 | F>I | No | EVA | |
| rs3388951358 | 548 | L>F | No | EVA | |
| rs3398768426 | 552 | R>* | No | EVA | |
| rs3397759924 | 555 | L>R | No | EVA | |
| rs3413056207 | 556 | T>N | No | EVA | |
| rs3388951567 | 567 | D>E | No | EVA | |
| rs3398136230 | 597 | L>I | No | EVA | |
| rs3388947071 | 624 | E>G | No | EVA | |
| rs31685598 | 629 | A>T | No | EVA | |
| rs3388942294 | 643 | L>R | No | EVA |
No associated diseases with Q8R3C0
No regional properties for Q8R3C0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8R3C0 | |||
Functions
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell junction | A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| MCM complex | A hexameric protein complex required for the initiation and regulation of DNA replication. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| DNA-templated DNA replication | A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. |
| sister chromatid cohesion | The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5ZJV4 | MCMBP | Mini-chromosome maintenance complex-binding protein | Gallus gallus (Chicken) | PR |
| B1H268 | Mcmbp | Mini-chromosome maintenance complex-binding protein | Rattus norvegicus (Rat) | PR |
| Q803A6 | mcmbp | Mini-chromosome maintenance complex-binding protein | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPCGEDWLSH | PLGIVQGFFA | QNGVNPDWEK | KVIEYFKEKL | KENNAPKWVP | SLNEVPLHYL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KPNSFVKFRC | MIQDMFDPEF | YMGIYETVNQ | NTKARVLHFG | KYRDVAECGP | QQELDLSSPR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| STTSERQTFY | CVPVPGESSW | VKEAYVNANQ | ARVSPSTSYT | PSRHKRSYED | DEDMDLQPSK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QKEQHPGSRQ | AGGLGGLHWC | GEPKRLETEA | SSGQQLNTLN | LSSPFDLNFP | LPGEKGPACL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VKVYEDWDCF | KVNDVLELYG | VLSVDPVLSV | LNSEERDASA | LLDPMECTDM | AEEQRVHSPP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ASLVPRIHVI | LAQKLQHINP | LLPTCLNKEE | SRSCQFVSNF | MSELSPVRAE | LLGFLTHALL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GDSLAAEYLI | LHLISTVYTR | RDVLPLGKFT | VNLSGCPQNS | TFTEHLYRII | QHLVPASFRL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QMTIENMNQL | KLIPHKDYTA | NRLVSGLLQL | PNNTSLVIDE | TLLEQGQLDT | PGVHNVTALS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NLITWQKVDY | DFSYHQMEFP | CNINVLITSE | GRSLLPADCQ | IHLQPQLIPP | NMEEYMNGLL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SAVLPSVLNK | FRIYLTLLRF | LDYNLSDDIT | KAVEDDFVEM | RKDDPQSITA | DDLHQLLVVA |
| 610 | 620 | 630 | 640 | ||
| RFLSLSVGQT | TLSRERWLRA | KQLELSRKAR | LQQQKSVNGN | EL |