B1H268

PR
Gene name
Mcmbp
Protein name
Mini-chromosome maintenance complex-binding protein
Names
MCM-BP, MCM-binding protein
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:309009
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

131-245 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for B1H268

Entry ID Method Resolution Chain Position Source
AF-B1H268-F1 Predicted AlphaFoldDB

No variants for B1H268

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for B1H268

No associated diseases with B1H268

No regional properties for B1H268

Type Name Position InterPro Accession
No domain, repeats, and functional sites for B1H268

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Associates with chromatin
  • Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase
  • It then reassociates with chromatin in late M phase
  • Dissociates from chromatin later than component of the MCM complex (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.

3 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.
sister chromatid cohesion The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5ZJV4 MCMBP Mini-chromosome maintenance complex-binding protein Gallus gallus (Chicken) PR
Q8R3C0 Mcmbp Mini-chromosome maintenance complex-binding protein Mus musculus (Mouse) PR
Q803A6 mcmbp Mini-chromosome maintenance complex-binding protein Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MPCGEDWLSH PLGIVQGFFA QNGVTPDWEK KVIDYFKEKL KENNAPKWVP SLNEVPLHYL
70 80 90 100 110 120
KPNSFVKFRC MIQDMFDPEF YMGVYETVNQ NTKARVLHFG KYRDVAECGP QQELDLNSPR
130 140 150 160 170 180
STTSERQTFY CVPVPGESLW VKEAYVNANQ ARVSPSTSYT PSRHKRSYED DEDMDLQPNK
190 200 210 220 230 240
QKDQHSGARQ AGGLGGLHWR GEPKRLETEA SSGQQLNSLN LSSPFDLNFP LPGEKGPACL
250 260 270 280 290 300
VKVYEDWDCF KVNDVLELYG VLSVDPILSI LNNEERDASA LLDPMECTDM AEEQRVHSPP
310 320 330 340 350 360
ASLVPRIHVI LAQKLQHINP LLPTCLNKEE SRTCQFVSNF MSELSPVRAE LLGFLTHALL
370 380 390 400 410 420
GDSLAAEYLI LHLISTVYTR RDVLPLGKFT VNLSGCPQNS TFTEHLYRII QHLVPASFRL
430 440 450 460 470 480
QMTIENMNQL KLIPHKDYTA NRLVSGLLQL PNNTSLVIDE TLLEQGQLDT PGVHNVAALS
490 500 510 520 530 540
NLITWQKVDY DFSYHQMEFP CNINVLITSE GRSLLPADCQ IHLQPQLIPP NMEEYMNGLL
550 560 570 580 590 600
SAVLPSVLNK FRIYLTLLRF LDYNLSDDIT KAVEDDFVEM RKNDPQSITA DDLHQLLVVA
610 620 630 640
RFLSLSAGQT TLSRERWLRA KQLEHSRRSR LQQQKSVNGN EL