Q8R1N4

PR
Gene name
Nudcd3 (Kiaa1068)
Protein name
NudC domain-containing protein 3
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:209586
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

87-202 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8R1N4

Entry ID Method Resolution Chain Position Source
AF-Q8R1N4-F1 Predicted AlphaFoldDB

14 variants for Q8R1N4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389147371 18 Q>R No EVA
rs3389136928 32 G>V No EVA
rs3389140681 33 F>L No EVA
rs26899852 46 H>Q No EVA
rs254732429 104 E>K No EVA
rs13466422 106 V>E No EVA
rs3401793253 141 E>K No EVA
rs265065050 143 T>K No EVA
rs3389140708 204 R>K No EVA
rs238870857 231 V>L No EVA
rs3389143321 248 I>N No EVA
rs3389105311 249 N>S No EVA
rs3389134922 255 W>* No EVA
rs255849383 276 S>N No EVA

No associated diseases with Q8R1N4

3 regional properties for Q8R1N4

Type Name Position InterPro Accession
domain CS domain 187 - 279 IPR007052
domain NudC N-terminal domain 9 - 67 IPR025934
domain NudC domain-containing protein 3, p23 domain 186 - 287 IPR037905

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic dynein complex Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.

1 GO annotations of molecular function

Name Definition
unfolded protein binding Binding to an unfolded protein.

3 GO annotations of biological process

Name Definition
cilium assembly The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein localization to pericentriolar material A process in which a protein is transported to, or maintained in, a location within a pericentriolar material.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8IVD9 NUDCD3 NudC domain-containing protein 3 Homo sapiens (Human) PR
10 20 30 40 50 60
MEPGAAELYD QALLGILQHV GNVQDFLRVL FGFLYRKTDF YRLLRHPSDR MGFPPGAAQA
70 80 90 100 110 120
LVLQVFKTFD HMARQDDEKR KKELEEKIRK KEEEAKALPA AETEKVAVPV PVQEVEIDAA
130 140 150 160 170 180
ADLSGPQEVE KEEPPGSQDP EHTVTHGLEK AEAPGTVSSA AEGPKDPPVL PRIQEQFQKN
190 200 210 220 230 240
PDSYNGAIRE NYIWSQDYTD LEVRVPVPKH VMKGKQVSVA LSSGTIRVAM VEENGERVLM
250 260 270 280 290 300
EGKLTHKINT ESSLWSLEPG RCVLVNLSKV GEYWWSAILE GEEPIDIDKI NKERSMATVD
310 320 330 340 350 360
EEEQAVLDRL TFDYHQKLQG KPQSHELKVH EMLKKGWDAE GSPFRGQRFD PAMFNISPGA
VQF