AiPD: Autoinhibited Protein Database

Q8IVD9

Gene name	NUDCD3 (KIAA1068)
Protein name	NudC domain-containing protein 3
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:23386
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

80-209 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

80-209 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for Q8IVD9

Entry ID	Method	Resolution	Chain	Position	Source
1WGV	NMR	-	A	176-286	PDB
AF-Q8IVD9-F1	Predicted				AlphaFoldDB

294 variants for Q8IVD9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs307007 CA157930553	3	T>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs762179144 CA4241320	3	T>K		No	ClinGen ExAC gnomAD
VAR_054036 rs307007 CA4241321	3	T>P		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1382050170 CA367387328	4	G>E		No	ClinGen gnomAD
CA4241318 rs146329778	5	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs373059594 CA4241317	5	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA367387287 rs1183887921	6	A>V		No	ClinGen gnomAD
rs775686676 CA4241316	7	E>K		No	ClinGen ExAC TOPMed gnomAD
rs377401450 CA157930509	9	Y>C		No	ClinGen ESP TOPMed gnomAD
rs1284564258 CA367387163	10	D>G		No	ClinGen TOPMed gnomAD
CA4241314 rs745919662	11	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs373111430 CA4241312	13	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA4241313 rs373111430	13	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA4241310 rs777702916	14	L>F		No	ClinGen ExAC
rs189900651 CA4241311	14	L>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA367387003 rs1376432982	15	G>C		No	ClinGen gnomAD
TCGA novel	17	L>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367386921 rs1292480325	18	Q>H		No	ClinGen TOPMed gnomAD
CA367386927 rs1281001032	18	Q>R		No	ClinGen TOPMed
CA367386900 rs1350507784	19	H>Y		No	ClinGen gnomAD
CA367386872 rs1362197797	20	V>L		No	ClinGen gnomAD
CA157930476 rs866447926	21	G>V		No	ClinGen Ensembl
rs755869101 CA4241309	22	N>I		No	ClinGen ExAC gnomAD
TCGA novel	24	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4241308 rs752317758	24	Q>R		No	ClinGen ExAC gnomAD
rs1228510022 CA367386703	25	D>N		No	ClinGen TOPMed
rs1422291283 CA367386623	28	R>C		No	ClinGen TOPMed gnomAD
rs201423294 CA4241306	29	V>I		No	ClinGen ExAC TOPMed gnomAD
rs751027167 CA4241305	30	L>H		No	ClinGen ExAC gnomAD
rs1406792885 CA367386580	31	F>L		No	ClinGen gnomAD
rs1406792885 CA367386577	31	F>V		No	ClinGen gnomAD
CA4241303 rs369984670	32	G>C		No	ClinGen ESP ExAC gnomAD
CA4241300 rs373365864	35	Y>H		No	ClinGen ESP ExAC gnomAD
CA367386441 rs1473039389	36	R>C		No	ClinGen TOPMed
rs1292351262 CA367386435	36	R>H		No	ClinGen TOPMed gnomAD
rs569119981 CA4241299	37	K>R	Variant assessed as Somatic; 4.833e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs772265765 CA4241298	38	T>I		No	ClinGen ExAC gnomAD
rs759547552 CA4241297	39	D>G		No	ClinGen ExAC gnomAD
TCGA novel	39	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4241296 rs774559000	40	F>L		No	ClinGen ExAC TOPMed gnomAD
CA157930407 rs1022962801	41	Y>C		No	ClinGen TOPMed gnomAD
rs1406592584 CA367386212	44	L>P		No	ClinGen TOPMed
rs1393787690 CA367386193	45	R>H		No	ClinGen TOPMed gnomAD
rs749204458 CA367386157 CA4241294	46	H>Q		No	ClinGen ExAC gnomAD
rs747911756 CA4241291	48	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4241292 rs769744697	48	S>P		No	ClinGen ExAC gnomAD
rs369942216 CA367386122	49	D>H		No	ClinGen ESP TOPMed
rs369942216 CA157930364	49	D>N		No	ClinGen ESP TOPMed
CA157930356 rs867641636	50	R>H		No	ClinGen TOPMed gnomAD
rs867641636 CA367386073	50	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs780721403 CA4241290	51	M>L		No	ClinGen ExAC TOPMed gnomAD
CA367386054 rs1189963072	51	M>T		No	ClinGen gnomAD
rs940942736 CA157930340	52	G>S		No	ClinGen TOPMed gnomAD
rs1198952792 CA367385963	55	P>A		No	ClinGen gnomAD
CA4241286 rs757812999	56	G>A		No	ClinGen ExAC gnomAD
CA367385941 rs779511167	56	G>R		No	ClinGen ExAC TOPMed gnomAD
rs779511167 CA4241287	56	G>W		No	ClinGen ExAC TOPMed gnomAD
rs1483554719 CA367385903	58	A>V		No	ClinGen TOPMed
rs1303368925 CA367385898	59	Q>E		No	ClinGen gnomAD
CA4241284 rs764541873	60	A>S		No	ClinGen ExAC gnomAD
CA157930252 rs962756833	61	L>M		No	ClinGen TOPMed
CA367385855 rs1016986453	63	L>M		No	ClinGen TOPMed
CA4241271 rs367883334	65	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA367383913 rs1563192046	66	F>L		No	ClinGen Ensembl
CA367383902 rs1326365217	67	K>E		No	ClinGen TOPMed
CA367383890 rs1585111952	67	K>N		No	ClinGen Ensembl
rs1396338586 CA367383876	68	T>S		No	ClinGen TOPMed
rs779631530 CA4241270	69	F>L		No	ClinGen ExAC gnomAD
CA4241269 rs757931682	72	M>L		No	ClinGen ExAC TOPMed gnomAD
rs757931682 CA367383765	72	M>V		No	ClinGen ExAC TOPMed gnomAD
CA367383731 rs1442578250	73	A>T		No	ClinGen gnomAD
CA4241267 rs371421304	74	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs756631027 CA4241266	74	R>H		No	ClinGen ExAC TOPMed gnomAD
CA367383587 rs1285843881	77	D>A		No	ClinGen TOPMed
rs1286710003 CA367383561	78	E>K		No	ClinGen gnomAD
CA367383398 rs1348718803	83	E>D		No	ClinGen gnomAD
rs1234394576 CA367383416	83	E>K		No	ClinGen TOPMed
CA4241264 rs767890675	84	L>F		No	ClinGen ExAC TOPMed gnomAD
rs550366011 CA4241263	85	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs1354664266 CA367383276	89	R>G		No	ClinGen TOPMed
TCGA novel	89	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1209514130 CA367383225	91	K>R		No	ClinGen TOPMed
rs372229653 CA4241262	93	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs200684595 CA4241260	94	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1053400213 CA157925855	95	E>G		No	ClinGen TOPMed
CA4241259 rs773412531	95	E>K		No	ClinGen ExAC gnomAD
rs200164721 CA4241257	99	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA367383030 rs1370015757	101	A>T		No	ClinGen TOPMed
rs768521852 CA4241255	103	A>T		No	ClinGen ExAC
rs1456191796 CA367382981	104	A>P		No	ClinGen TOPMed
rs1369785350 CA367382937	107	E>Q		No	ClinGen gnomAD
CA4241254 rs746764203	107	E>V		No	ClinGen ExAC
rs775125688 CA4241253	109	V>F		No	ClinGen ExAC gnomAD
CA367382886 rs1263626812	111	V>F		No	ClinGen gnomAD
CA4241252 rs771651439	112	P>T		No	ClinGen ExAC gnomAD
rs1392703993 CA367382867	113	V>G		No	ClinGen TOPMed
CA367382829 rs745436649	115	E>D		No	ClinGen ExAC gnomAD
TCGA novel	115	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4241250 rs778481864	116	I>T		No	ClinGen ExAC gnomAD
TCGA novel	117	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs189139007 CA157925802	118	I>V		No	ClinGen 1000Genomes TOPMed
rs1210467586 CA367382762	119	D>N		No	ClinGen gnomAD
rs1044009496 CA157925801	120	S>C		No	ClinGen TOPMed gnomAD
rs370945060 CA4241248	121	T>I		No	ClinGen ESP ExAC gnomAD
CA367382686 rs1232869672	122	T>R		No	ClinGen gnomAD
rs61745062 CA4241247	123	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201221635 CA4241246	123	E>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs766766388 CA4241244	125	D>N		No	ClinGen ExAC gnomAD
CA367382607 rs1252196252	126	G>E		No	ClinGen TOPMed
CA367382614 rs1405491166	126	G>R		No	ClinGen gnomAD
CA367382610 rs1405491166	126	G>W		No	ClinGen gnomAD
rs758689871 CA4241243	128	Q>H		No	ClinGen ExAC gnomAD
CA367382519 rs1162432009	129	E>G		No	ClinGen gnomAD
CA157925716 rs988368420	130	V>G		No	ClinGen TOPMed
rs368303594 CA4241241	130	V>I		No	ClinGen ESP ExAC gnomAD
rs761752415 CA4241240	131	E>D		No	ClinGen ExAC gnomAD
rs944855380 CA157925715	131	E>V		No	ClinGen TOPMed
rs776659627 CA4241239	133	V>E		No	ClinGen ExAC gnomAD
rs1474406211 CA367382415	133	V>M		No	ClinGen gnomAD
CA4241238 CA157925672 rs115164631	134	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs370549116 CA4241236	136	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA367382262 rs1585111641	139	V>M		No	ClinGen Ensembl
rs745487952 CA4241234	142	M>I		No	ClinGen ExAC gnomAD
CA4241232 rs770495408	143	A>D		No	ClinGen ExAC TOPMed gnomAD
CA4241233 rs770495408	143	A>V		No	ClinGen ExAC TOPMed gnomAD
CA4241231 rs748681908	144	H>R		No	ClinGen ExAC gnomAD
rs1206108894 CA367382144	144	H>Y		No	ClinGen gnomAD
rs953619201 CA157925602	145	G>S		No	ClinGen TOPMed
rs1275999400 CA367382060	146	S>L		No	ClinGen gnomAD
rs138070211 CA367382034	147	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA157925578 rs199516211	148	E>D		No	ClinGen 1000Genomes ExAC gnomAD
CA157925568 rs543622747	149	A>T		No	ClinGen 1000Genomes gnomAD
CA4241226 rs758746958	151	A>T		No	ClinGen ExAC gnomAD
CA367381885 rs1585111583	152	P>L		No	ClinGen Ensembl
rs369865643 CA157925552	154	A>E		No	ClinGen Ensembl
CA367381866 rs1418492484	154	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1369447454 CA367381845	155	V>I		No	ClinGen TOPMed
rs778965814 CA4241224	156	A>S		No	ClinGen ExAC gnomAD
CA4241223 rs757360285	158	A>P		No	ClinGen ExAC TOPMed gnomAD
CA4241221 rs764146504	159	A>G		No	ClinGen ExAC gnomAD
rs753799747 CA4241222	159	A>P		No	ClinGen ExAC gnomAD
CA367381712 rs764146504	159	A>V		No	ClinGen ExAC gnomAD
CA367381673 rs1437679039	160	E>D		No	ClinGen gnomAD
CA157925528 rs1014822130	160	E>K		No	ClinGen TOPMed
COSM1259693 CA157925523 rs1014822130	160	E>Q	oesophagus [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1585111535 CA367381671	161	V>I		No	ClinGen Ensembl
CA4241219 rs752529149	162	P>A		No	ClinGen ExAC gnomAD
rs767277652 CA4241218	163	R>K		No	ClinGen ExAC gnomAD
TCGA novel	163	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367381566 rs1300668656	165	P>Q		No	ClinGen gnomAD
rs1232870515 CA367381548	166	P>A		No	ClinGen gnomAD
rs34435177 CA367381520	167	I>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs774082717 CA4241216	167	I>S		No	ClinGen ExAC gnomAD
CA4241217 rs34435177	167	I>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA367381488 COSM232919 rs1439567139	168	L>F	skin [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA367381491 rs1439567139	168	L>V		No	ClinGen TOPMed gnomAD
CA4241215 rs770435609	169	P>L		No	ClinGen ExAC gnomAD
rs1436537216 CA367381432	170	R>G		No	ClinGen TOPMed gnomAD
rs998198277 CA157943571	170	R>S		No	ClinGen TOPMed
CA157943566 rs777794280	175	F>L		No	ClinGen Ensembl
CA367555703 rs1410497638	179	P>L		No	ClinGen gnomAD
rs757750498 CA4241066	180	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA367555693 rs1242290336	181	S>G		No	ClinGen TOPMed
CA367555691 rs1482818500	181	S>T		No	ClinGen Ensembl
rs1428973141 CA367555675	183	N>S		No	ClinGen TOPMed
rs749820004 CA4241065	187	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs778099333 CA4241064	187	R>Q		No	ClinGen ExAC gnomAD
rs756504391 CA4241063	189	N>S		No	ClinGen ExAC gnomAD
CA367555607 rs1208761561	193	S>L		No	ClinGen gnomAD
rs1316967733 CA367555585	196	Y>C		No	ClinGen gnomAD
CA4241061 rs375774867	199	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA367555556 rs1461446041	201	V>I		No	ClinGen TOPMed
rs766588627 CA4241058 CA4241059	202	R>S		No	ClinGen ExAC gnomAD
rs762903299 CA4241057	203	V>L		No	ClinGen ExAC gnomAD
rs1353432621 CA367555521	207	K>E		No	ClinGen gnomAD
rs1431626602 CA367555505	209	V>M		No	ClinGen gnomAD
rs888320964 CA157943535	210	V>L		No	ClinGen TOPMed gnomAD
CA367555498 rs888320964	210	V>M		No	ClinGen TOPMed gnomAD
CA4241055 rs201734344	211	K>R		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	213	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1015376214 CA157935176	223	S>A		No	ClinGen TOPMed
CA4241028 rs770372752	223	S>Y		No	ClinGen ExAC TOPMed gnomAD
rs748688442 COSM1089939 CA4241027	225	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA4241026 rs201065672	225	R>H		No	ClinGen 1000Genomes ExAC gnomAD
rs201065672 CA367555191	225	R>L		No	ClinGen 1000Genomes ExAC gnomAD
rs1299057325 CA367555190	226	V>M		No	ClinGen gnomAD
CA4241025 rs769148630	227	A>V		No	ClinGen ExAC gnomAD
CA367555167 rs1168473840	229	L>P		No	ClinGen gnomAD
rs747321112 CA4241024	230	E>V		No	ClinGen ExAC gnomAD
rs140515906 CA4241023	232	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs758548123 CA4241022	232	N>T		No	ClinGen ExAC TOPMed gnomAD
rs750560463 CA4241021	233	G>E		No	ClinGen ExAC gnomAD
rs11550029 VAR_031709 CA4241019	235	R>C		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA4241018 rs142257577	235	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA157935131 rs201003414	236	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs201003414 CA4241016	236	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA367555121 rs1282475970	237	L>F		No	ClinGen gnomAD
rs1307946950 CA367555113	238	M>T		No	ClinGen gnomAD
rs913303955 CA157935110	243	T>A		No	ClinGen Ensembl
CA4241013 rs765176728	244	H>L		No	ClinGen ExAC gnomAD
rs1464251698 CA367555068	245	K>Q		No	ClinGen gnomAD
CA4241012 rs372479007	245	K>R		No	ClinGen ExAC TOPMed
TCGA novel	245	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1376765908 CA367555052	247	N>Y		No	ClinGen gnomAD
rs765838784 CA4241011	248	T>A		No	ClinGen ExAC gnomAD
CA367555037 rs1420725699	249	E>G		No	ClinGen gnomAD
CA367555032 rs762486546	250	S>C		No	ClinGen ExAC gnomAD
rs762486546 CA4241010	250	S>R		No	ClinGen ExAC gnomAD
CA157935079 rs947619595	251	S>F		No	ClinGen TOPMed
CA367555025 rs1169860233	251	S>P		No	ClinGen gnomAD
TCGA novel	251	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777292008 CA4241009	252	L>V		No	ClinGen ExAC TOPMed gnomAD
CA157935070 rs938783296	254	S>G		No	ClinGen TOPMed
rs55683944 CA157935061	256	E>K		No	ClinGen TOPMed gnomAD
CA157935058 rs55683944	256	E>Q		No	ClinGen TOPMed gnomAD
rs1261601495 CA367554986	257	P>H		No	ClinGen gnomAD
CA4241006 rs759531529	257	P>S		No	ClinGen ExAC TOPMed gnomAD
COSM1450914 rs969997957 CA157935042	258	G>R	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1187633701 CA367554974	259	K>R		No	ClinGen TOPMed gnomAD
rs779151517 CA4241003	260	C>Y		No	ClinGen ExAC gnomAD
rs749305682 CA4241001	261	V>I		No	ClinGen ExAC TOPMed gnomAD
CA367554120 rs1280042105	264	N>D		No	ClinGen TOPMed
rs1338285106 CA367554104	266	S>T		No	ClinGen TOPMed
CA157927833 rs751357483	268	V>L		No	ClinGen ExAC TOPMed gnomAD
CA4240975 rs751357483	268	V>M		No	ClinGen ExAC TOPMed gnomAD
rs145712203 CA4240972	270	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA
rs1585049869 CA367554059	272	W>C		No	ClinGen Ensembl
TCGA novel	273	W>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4240971 rs764865453	274	N>D		No	ClinGen ExAC gnomAD
rs562538702 CA4240970	274	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA367554041 rs1174300328	275	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1416217621 CA367554035	276	I>F		No	ClinGen gnomAD
rs140073158 CA4240968	278	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA4240967 rs759872496	281	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1265976276 CA367553996	282	P>A		No	ClinGen TOPMed
rs970049066 CA157927781	282	P>L		No	ClinGen TOPMed
CA367553991 rs1377763783	283	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA4240964 rs763137837	284	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA157927767 rs771366456	285	I>V		No	ClinGen Ensembl
CA157927756 rs899192050	287	K>R		No	ClinGen TOPMed gnomAD
CA157927763 rs899192050	287	K>T		No	ClinGen TOPMed gnomAD
TCGA novel	288	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA367553951 rs1211041965	288	I>M		No	ClinGen gnomAD
rs1483107869 CA367553945	289	N>S		No	ClinGen gnomAD
rs879667846 CA157927747	290	K>R		No	ClinGen TOPMed
rs1420112449 CA367553933	291	E>Q		No	ClinGen TOPMed
rs773373200 CA4240961	292	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1218266712 CA367553925	292	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA157927740 rs369527166	293	S>T		No	ClinGen ESP TOPMed gnomAD
CA157927734 rs1011981796	294	M>V		No	ClinGen TOPMed
CA157927727 rs147519520	297	V>M		No	ClinGen ESP TOPMed gnomAD
rs149687229 CA4240960	298	D>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs369206508 CA4240958	303	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA157927701 rs79020500	304	V>G		No	ClinGen Ensembl
CA157927703 rs1051636815	304	V>M		No	ClinGen Ensembl
rs1333761690 CA367553829	307	R>G		No	ClinGen gnomAD
CA4240955 rs779976154	308	L>V		No	ClinGen ExAC TOPMed gnomAD
rs758222272 CA4240954	311	D>E		No	ClinGen ExAC gnomAD
rs1472451165 CA367553792	312	Y>S		No	ClinGen gnomAD
CA367553785 rs1585049725	313	H>P		No	ClinGen Ensembl
CA4240952 rs778637751	313	H>Q		No	ClinGen ExAC gnomAD
CA367553769 rs1268652474	315	K>R		No	ClinGen TOPMed
rs921895254 CA157927664	317	Q>E		No	ClinGen Ensembl
rs753372746 CA4240950	317	Q>H		No	ClinGen ExAC gnomAD
rs767972859 CA4240949	318	G>D		No	ClinGen ExAC gnomAD
rs201551368 CA4240947	320	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs766813840 CA4240926	328	H>N		No	ClinGen ExAC gnomAD
CA367553617 rs1554486232	328	H>R		No	ClinGen Ensembl
TCGA novel	329	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs371599060 CA4240925	330	M>I		No	ClinGen ESP ExAC gnomAD
CA367553605 rs1178495334	330	M>V		No	ClinGen TOPMed
rs1295602374 CA367553574	334	G>R		No	ClinGen TOPMed gnomAD
rs765419349 CA4240923	338	E>A		No	ClinGen ExAC gnomAD
CA367553540 rs1349846297	338	E>K		No	ClinGen TOPMed gnomAD
CA367553539 rs1349846297	338	E>Q		No	ClinGen TOPMed gnomAD
CA4240921 rs776671458	343	R>*		No	ClinGen ExAC gnomAD
rs1410648930 CA367553485	343	R>Q		No	ClinGen gnomAD
CA4240920 rs139501693	346	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA367553434 rs1585045990	348	D>A		No	ClinGen Ensembl
COSM189000 rs760773518 CA4240919	348	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA4240917 rs772118837	351	M>I		No	ClinGen ExAC gnomAD
rs775577561 CA4240918	351	M>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs745721645 CA4240916	352	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1282495331 CA367553375	353	N>S		No	ClinGen TOPMed
CA4240913 rs776014477	356	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs770536144 CA4240914	356	P>S		No	ClinGen ExAC gnomAD
CA367553310 rs777107422	357	G>A		No	ClinGen ExAC TOPMed gnomAD
rs777107422 CA4240911	357	G>E		No	ClinGen ExAC TOPMed gnomAD
rs947164919 CA157922978	357	G>W		No	ClinGen gnomAD
rs1367346736 CA367553308	358	A>T		No	ClinGen TOPMed gnomAD
rs750833397 CA4240907	359	V>A		No	ClinGen ExAC gnomAD
CA4240908 rs758871075	359	V>L		No	ClinGen ExAC gnomAD
CA4240909 rs758871075	359	V>M		No	ClinGen ExAC gnomAD
CA4240906 rs201868328	360	Q>H		No	ClinGen 1000Genomes ExAC gnomAD

No associated diseases with Q8IVD9

3 regional properties for Q8IVD9

Type	Name	Position	InterPro Accession
domain	CS domain	185 - 277	IPR007052
domain	NudC N-terminal domain	9 - 67	IPR025934
domain	NudC domain-containing protein 3, p23 domain	184 - 285	IPR037905

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic dynein complex	Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.

1 GO annotations of molecular function

Name	Definition
unfolded protein binding	Binding to an unfolded protein.

3 GO annotations of biological process

Name	Definition
cilium assembly	The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
protein folding	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein localization to pericentriolar material	A process in which a protein is transported to, or maintained in, a location within a pericentriolar material.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8R1N4	Nudcd3	NudC domain-containing protein 3	Mus musculus (Mouse)	PR

10	20	30	40	50	60
METGAAELYD	QALLGILQHV	GNVQDFLRVL	FGFLYRKTDF	YRLLRHPSDR	MGFPPGAAQA
70	80	90	100	110	120
LVLQVFKTFD	HMARQDDEKR	RQELEEKIRR	KEEEEAKTVS	AAAAEKEPVP	VPVQEIEIDS
130	140	150	160	170	180
TTELDGHQEV	EKVQPPGPVK	EMAHGSQEAE	APGAVAGAAE	VPREPPILPR	IQEQFQKNPD
190	200	210	220	230	240
SYNGAVRENY	TWSQDYTDLE	VRVPVPKHVV	KGKQVSVALS	SSSIRVAMLE	ENGERVLMEG
250	260	270	280	290	300
KLTHKINTES	SLWSLEPGKC	VLVNLSKVGE	YWWNAILEGE	EPIDIDKINK	ERSMATVDEE
310	320	330	340	350	360
EQAVLDRLTF	DYHQKLQGKP	QSHELKVHEM	LKKGWDAEGS	PFRGQRFDPA	MFNISPGAVQ

F