AiPD: Autoinhibited Protein Database

Gene name	Aldh1l1
Protein name	Cytosolic 10-formyltetrahydrofolate dehydrogenase
Names	10-FTHFDH, FDH, Aldehyde dehydrogenase family 1 member L1
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:107747
EC number	1.5.1.6: With NAD(+) or NADP(+) as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

159-232 (Predicted disordered autoinhibitory region) PR

159-232 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8R0Y6-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388845765	6	I>M	No	EVA
rs3388849600	10	L>V	No	EVA
rs3388849537	18	Q>H	No	EVA
rs3388839412	19	L>Q	No	EVA
rs3388849558	37	G>R	No	EVA
rs3388845282	53	V>M	No	EVA
rs3397102579	77	G>A	No	EVA
rs3388838496	115	G>E	No	EVA
rs240169178	153	D>E	No	EVA
rs3396968076	166	R>H	No	EVA
rs3388809242	168	L>P	No	EVA
rs3388851144	187	T>A	No	EVA
rs3388845773	188	A>T	No	EVA
rs36794236	210	M>R	No	EVA
rs263119818	275	A>E	No	EVA
rs263119818	275	A>V	No	EVA
rs3397098740	277	L>V	No	EVA
rs3397098737	279	L>R	No	EVA
rs3388843099	305	F>Y	No	EVA
rs3397092690	309	S>T	No	EVA
rs3396883275	312	S>R	No	EVA
rs3396624254	313	A>P	No	EVA
rs3396784818	315	E>K	No	EVA
rs3388845346	353	A>T	No	EVA
rs3388849567	374	E>D	No	EVA
rs3388838573	395	L>*	No	EVA
rs36884257	400	G>D	No	EVA
rs239432715	414	K>N	No	EVA
rs3388827711	429	E>D	No	EVA
rs3388845814	464	A>V	No	EVA
rs3388847398	468	A>G	No	EVA
rs3388845274	540	I>N	No	EVA
rs3397092640	545	I>*	No	EVA
rs3397092682	582	W>C	No	EVA
rs3396618378	582	W>S	No	EVA
rs3397038155	583	K>R	No	EVA
rs3397027832	586	A>S	No	EVA
rs3388839596	586	A>V	No	EVA
rs3388843112	609	F>L	No	EVA
rs3388833945	621	G>C	No	EVA
rs3397038114	621	G>D	No	EVA
rs3388843285	629	S>Y	No	EVA
rs3388833900	645	K>N	No	EVA
rs3388847486	691	A>V	No	EVA
rs3388847467	702	N>K	No	EVA
rs3388827718	704	G>R	No	EVA
rs3388839626	713	L>I	No	EVA
rs3388847422	755	L>M	No	EVA
rs3388809180	769	G>R	No	EVA
rs37608620	774	C>Y	No	EVA
rs3388839459	785	F>L	No	EVA
rs37064932	790	V>I	No	EVA
rs3388849542	798	M>V	No	EVA
rs38748377	806	F>L	No	EVA
rs3388849605	817	D>V	No	EVA
rs3388845327	830	T>I	No	EVA
rs3388843134	849	V>F	No	EVA
rs3388839405	850	S>N	No	EVA
rs36602348	855	A>T	No	EVA
rs3388833875	887	A>T	No	EVA
rs3388839616	898	V>A	No	EVA

Type	Name	Position	InterPro Accession
active_site	Phosphoribosylglycinamide formyltransferase, active site	131 - 154	IPR001555
domain	Formyl transferase, N-terminal	1 - 180	IPR002376
domain	Formyl transferase, C-terminal	205 - 309	IPR005793
domain	Phosphopantetheine binding ACP domain	318 - 395	IPR009081
domain	Aldehyde dehydrogenase domain	430 - 898	IPR015590
conserved_site	Aldehyde dehydrogenase, cysteine active site	700 - 711	IPR016160
conserved_site	Aldehyde dehydrogenase, glutamic acid active site	672 - 679	IPR029510

		Description
EC Number	1.5.1.6	With NAD(+) or NADP(+) as acceptor
Subcellular Localization	Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

Name	Definition
aldehyde dehydrogenase (NAD+) activity	Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
aldehyde dehydrogenase (NADP+) activity	Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+.
aldehyde dehydrogenase [NAD(P)+] activity	Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.
formyltetrahydrofolate dehydrogenase activity	Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO(2) + H(+) + NADPH.
hydroxymethyl-, formyl- and related transferase activity	Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor).
protein-containing complex binding	Binding to a macromolecular complex.

Name	Definition
10-formyltetrahydrofolate catabolic process	The chemical reactions and pathways resulting in the breakdown of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate.
biosynthetic process	The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
folic acid metabolic process	The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
NADPH regeneration	A metabolic process that generates a pool of NADPH by the reduction of NADP+.
one-carbon metabolic process	The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P28037	Aldh1l1	Cytosolic 10-formyltetrahydrofolate dehydrogenase	Rattus norvegicus (Rat)	PR