P28037

PR
Gene name
Aldh1l1
Protein name
Cytosolic 10-formyltetrahydrofolate dehydrogenase
Names
10-FTHFDH, FDH, Aldehyde dehydrogenase family 1 member L1, FBP-CI
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:64392
EC number
1.5.1.6: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

164-234 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

17 structures for P28037

Entry ID Method Resolution Chain Position Source
1S3I X-ray 230 A A 1-310 PDB
2O2P X-ray 170 A A/B/C/D 397-902 PDB
2O2Q X-ray 200 A A/B/C/D 397-902 PDB
2O2R X-ray 220 A A/B/C/D 397-902 PDB
3RHJ X-ray 189 A A/B/C/D 397-902 PDB
3RHL X-ray 200 A A/B/C/D 397-902 PDB
3RHM X-ray 238 A A/B/C/D 397-902 PDB
3RHO X-ray 226 A A/B/C/D 397-902 PDB
3RHP X-ray 250 A A/B/C/D 397-902 PDB
3RHQ X-ray 210 A A/B/C/D 397-902 PDB
3RHR X-ray 230 A A/B/C/D 397-902 PDB
4GNZ X-ray 230 A A/B/C/D 397-902 PDB
4GO0 X-ray 338 A A/B/C/D 397-902 PDB
4GO2 X-ray 228 A A/B/C/D 397-902 PDB
7RLT EM 370 A A/B/C/D 1-902 PDB
7RLU EM 290 A A/B/C/D 1-902 PDB
AF-P28037-F1 Predicted AlphaFoldDB

5 variants for P28037

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3320253589 386 G>E No EVA
rs3320191876 431 V>M No EVA
rs3320306368 488 L>P No EVA
rs3320320862 488 L>V No EVA
rs8162596 852 K>N No EVA

No associated diseases with P28037

7 regional properties for P28037

Type Name Position InterPro Accession
active_site Phosphoribosylglycinamide formyltransferase, active site 131 - 154 IPR001555
domain Formyl transferase, N-terminal 1 - 180 IPR002376
domain Formyl transferase, C-terminal 205 - 309 IPR005793
domain Phosphopantetheine binding ACP domain 318 - 395 IPR009081
domain Aldehyde dehydrogenase domain 430 - 898 IPR015590
conserved_site Aldehyde dehydrogenase, cysteine active site 700 - 711 IPR016160
conserved_site Aldehyde dehydrogenase, glutamic acid active site 672 - 679 IPR029510

Functions

Description
EC Number 1.5.1.6 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

6 GO annotations of molecular function

Name Definition
aldehyde dehydrogenase (NAD+) activity Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
aldehyde dehydrogenase (NADP+) activity Catalysis of the reaction: an aldehyde + NADP+ + H2O = an acid + NADPH + H+.
aldehyde dehydrogenase [NAD(P)+] activity Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.
formyltetrahydrofolate dehydrogenase activity Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO(2) + H(+) + NADPH.
hydroxymethyl-, formyl- and related transferase activity Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor).
protein-containing complex binding Binding to a macromolecular complex.

6 GO annotations of biological process

Name Definition
10-formyltetrahydrofolate catabolic process The chemical reactions and pathways resulting in the breakdown of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate.
bile acid signaling pathway The series of molecular signals initiated by bile acid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
folic acid metabolic process The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
NADPH regeneration A metabolic process that generates a pool of NADPH by the reduction of NADP+.
one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
tetrahydrofolate biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8R0Y6 Aldh1l1 Cytosolic 10-formyltetrahydrofolate dehydrogenase Mus musculus (Mouse) PR
10 20 30 40 50 60
MKIAVIGQSL FGQEVYCQLR KEGHEVVGVF TIPDKDGKAD PLGLEAEKDG VPVFKFPRWR
70 80 90 100 110 120
ARGQALPEVV AKYQALGAEL NVLPFCSQFI PMEVINAPRH GSIIYHPSLL PRHRGASAIN
130 140 150 160 170 180
WTLIHGDKKG GFTIFWADDG LDTGDLLLQK ECEVLPDDTV STLYNRFLFP EGIKGMVQAV
190 200 210 220 230 240
RLIAEGTAPR CPQSEEGATY EGIQKKETAK INWDQPAEAI HNWIRGNDKV PGAWTEACGQ
250 260 270 280 290 300
KLTFFNSTLN TSGLSTQGEA LPIPGAHRPG VVTKAGLILF GNDDRMLLVK NIQLEDGKMM
310 320 330 340 350 360
PASQFFKGSA SSDLELTEAE LATAEAVRSS WMRILPNVPE VEDSTDFFKS GAASVDVVRL
370 380 390 400 410 420
VEEVKELCDG LELENEDVYM ATTFRGFIQL LVRKLRGEDD ESECVINYVE KAVNKLTLQM
430 440 450 460 470 480
PYQLFIGGEF VDAEGSKTYN TINPTDGSVI CQVSLAQVSD VDKAVAAAKE AFENGLWGKI
490 500 510 520 530 540
NARDRGRLLY RLADVMEQHQ EELATIEALD AGAVYTLALK THVGMSIQTF RYFAGWCDKI
550 560 570 580 590 600
QGATIPINQA RPNRNLTLTK KEPVGVCGIV IPWNYPLMML SWKTAACLAA GNTVVIKPAQ
610 620 630 640 650 660
VTPLTALKFA ELTLKAGIPK GVVNILPGSG SLVGQRLSDH PDVRKIGFTG STEVGKHIMK
670 680 690 700 710 720
SCALSNVKKV SLELGGKSPL IIFADCDLNK AVQMGMSSVF FNKGENCIAA GRLFVEESIH
730 740 750 760 770 780
NQFVQKVVEE VEKMKIGNPL ERDTNHGPQN HEAHLRKLVE YCQRGVKEGA TLVCGGNQVP
790 800 810 820 830 840
RPGFFFQPTV FTDVEDHMYI AKEESFGPIM IISRFADGDV DAVLSRANAT EFGLASGVFT
850 860 870 880 890 900
RDINKALYVS DKLQAGTVFI NTYNKTDVAA PFGGFKQSGF GKDLGEAALN EYLRIKTVTF
EY