Q8R035

PR
Gene name
Mrpl58
Protein name
Peptidyl-tRNA hydrolase ICT1, mitochondrial
Names
39S ribosomal protein L58, mitochondrial, MRP-L58, Immature colon carcinoma transcript 1 protein homolog
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:68572
EC number
3.1.1.29: Carboxylic ester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

132-206 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q8R035

Entry ID Method Resolution Chain Position Source
1J26 NMR - A 63-161 PDB
AF-Q8R035-F1 Predicted AlphaFoldDB

10 variants for Q8R035

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3402715714 4 A>T No EVA
rs211712969 16 T>M No EVA
rs221404901 155 R>Q No EVA
rs3389227389 163 Q>* No EVA
rs3389220678 169 S>F No EVA
rs235912755 174 R>Q No EVA
rs3389232184 182 K>* No EVA
rs3389212383 192 R>G No EVA
rs3389212365 206 D>Y No EVA
rs3402927251 207 D>E No EVA

No associated diseases with Q8R035

1 regional properties for Q8R035

Type Name Position InterPro Accession
domain Peptide chain release factor class I 71 - 199 IPR000352

Functions

Description
EC Number 3.1.1.29 Carboxylic ester hydrolases
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial large ribosomal subunit The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
aminoacyl-tRNA hydrolase activity Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.
translation release factor activity, codon nonspecific A translation release factor that is not specific to particular codons; binds to guanine nucleotides.

2 GO annotations of biological process

Name Definition
mitochondrial translation The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.
mitochondrial translational termination The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa).

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q14197 MRPL58 Peptidyl-tRNA hydrolase ICT1, mitochondrial Homo sapiens (Human) PR
10 20 30 40 50 60
MATAWGLRWG LSRTGTLLLA PPARCARRAL HRQVDGTTFQ SIYSLDKLYP ESKGADTAWK
70 80 90 100 110 120
VPEHAKQASS YIPLDRLSIS YCRSSGPGGQ NVNKVNSKAE VRFHLASADW IEEPVRQKIA
130 140 150 160 170 180
LTHKNKINKA GELVLTSESS RYQFRNLAEC LQKIRDMIAE ASQVPKEPSK EDARLQRLRI
190 200
EKMNRERLRQ KRLNSALKTS RRMTMD