AiPD: Autoinhibited Protein Database

Q14197

Gene name	MRPL58
Protein name	Peptidyl-tRNA hydrolase ICT1, mitochondrial
Names	39S ribosomal protein L58, mitochondrial, MRP-L58, Digestion substraction 1, DS-1, Immature colon carcinoma transcript 1 protein, Mitochondrial large ribosomal subunit protein mL62
Species	Homo sapiens (Human)
KEGG Pathway	hsa:3396
EC number	3.1.1.29: Carboxylic ester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

142-206 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

142-206 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

62 structures for Q14197

Entry ID	Method	Resolution	Chain	Position	Source
3J7Y	EM	340 A	p	1-206	PDB
3J9M	EM	350 A	p	1-206	PDB
5OOL	EM	306 A	p	1-206	PDB
5OOM	EM	303 A	p	1-206	PDB
6I9R	EM	390 A	p	1-206	PDB
6NU2	EM	390 A	p	38-193	PDB
6NU3	EM	440 A	p	1-206	PDB
6VLZ	EM	297 A	p	1-206	PDB
6VMI	EM	296 A	p	1-206	PDB
6ZM5	EM	289 A	p	1-206	PDB
6ZM6	EM	259 A	p	1-206	PDB
6ZS9	EM	400 A	p	1-206	PDB
6ZSA	EM	400 A	p	1-206	PDB
6ZSB	EM	450 A	p	1-206	PDB
6ZSC	EM	350 A	p	1-206	PDB
6ZSD	EM	370 A	p	1-206	PDB
6ZSE	EM	500 A	p	1-206	PDB
6ZSG	EM	400 A	p	1-206	PDB
7A5F	EM	440 A	p3	1-206	PDB
7A5G	EM	433 A	p3	1-206	PDB
7A5H	EM	330 A	p	1-206	PDB
7A5I	EM	370 A	p3	1-206	PDB
7A5J	EM	310 A	p	1-206	PDB
7A5K	EM	370 A	p3	1-206	PDB
7L08	EM	349 A	p	1-206	PDB
7L20	EM	315 A	p	1-206	PDB
7NQL	EM	340 A	BL	30-206	PDB
7O9K	EM	310 A	p	1-206	PDB
7O9M	EM	250 A	p	1-205	PDB
7ODR	EM	290 A	p	1-206	PDB
7ODS	EM	310 A	p	1-206	PDB
7ODT	EM	310 A	p	1-206	PDB
7OF0	EM	220 A	p	1-206	PDB
7OF2	EM	270 A	p	1-206	PDB
7OF3	EM	270 A	p	1-206	PDB
7OF4	EM	270 A	p	1-206	PDB
7OF5	EM	290 A	p	1-206	PDB
7OF6	EM	260 A	p	1-206	PDB
7OF7	EM	250 A	p	1-206	PDB
7OG4	EM	380 A	p	1-206	PDB
7OI6	EM	570 A	p	1-206	PDB
7OI7	EM	350 A	p	1-206	PDB
7OI8	EM	350 A	p	1-206	PDB
7OI9	EM	330 A	p	1-206	PDB
7OIA	EM	320 A	p	1-206	PDB
7OIB	EM	330 A	p	1-206	PDB
7OIC	EM	310 A	p	1-206	PDB
7OID	EM	370 A	p	1-206	PDB
7OIE	EM	350 A	p	1-206	PDB
7PD3	EM	340 A	p	1-206	PDB
7PO4	EM	256 A	p	1-206	PDB
7QH6	EM	308 A	p	1-206	PDB
7QH7	EM	289 A	p	38-193	PDB
7QI4	EM	221 A	p	1-206	PDB
7QI5	EM	263 A	p	1-206	PDB
7QI6	EM	298 A	p	1-206	PDB
8ANY	EM	285 A	p	1-206	PDB
8OIR	EM	310 A	Bf	1-206	PDB
8OIT	EM	290 A	Bf	1-206	PDB
8PK0	EM	303 A	p	1-206	PDB
8QSJ	EM	300 A	p	1-206	PDB
AF-Q14197-F1	Predicted				AlphaFoldDB

193 variants for Q14197

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA400965736 rs1336254280	2	A>E		No	ClinGen TOPMed
rs555924069 CA8756394	2	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs201411401 CA8756395	4	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA400965771 rs1441722722	4	T>I		No	ClinGen gnomAD
rs201411401 CA400965760	4	T>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA400965768 rs1441722722	4	T>S		No	ClinGen gnomAD
CA400965779 rs1352673278	5	R>G		No	ClinGen TOPMed gnomAD
rs746644693 CA8756397	5	R>S		No	ClinGen ExAC gnomAD
rs368786552 CA8756399	6	C>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs368786552 CA8756398	6	C>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs368786552 CA8756400	6	C>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8756402 rs773141152	7	L>P		No	ClinGen ExAC gnomAD
rs773141152 CA400965820	7	L>Q		No	ClinGen ExAC gnomAD
rs113361561 CA400965816	7	L>V		No	ClinGen ExAC TOPMed gnomAD
rs3744206 CA8756404	8	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8756405 VAR_020045 rs3744206	8	R>P		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs760868507 CA8756406	9	W>*		No	ClinGen ExAC gnomAD
rs1041691905 CA293967551	9	W>C		No	ClinGen TOPMed gnomAD
CA293967555 rs866434364	11	L>M		No	ClinGen gnomAD
rs866434364 CA400965878	11	L>V		No	ClinGen gnomAD
rs764486662 CA8756407	12	S>N		No	ClinGen ExAC gnomAD
rs754233014 CA8756408	13	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA8756409 TCGA novel rs771716388	15	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC TOPMed gnomAD NCI-TCGA
CA400965945 rs771716388	15	G>V		No	ClinGen ExAC TOPMed gnomAD
CA400965987 rs1360167140	18	L>V		No	ClinGen TOPMed
rs765677444 CA8756410	19	L>P		No	ClinGen ExAC gnomAD
rs1312437428 CA400966036	21	P>L		No	ClinGen gnomAD
CA400966027 rs1410738212	21	P>T		No	ClinGen gnomAD
CA400966050 rs1247581632	22	P>L		No	ClinGen TOPMed gnomAD
CA400966047 rs1247581632	22	P>R		No	ClinGen TOPMed gnomAD
rs1356374198 CA400966057	23	A>T		No	ClinGen gnomAD
CA8756413 rs540669075	24	R>W		No	ClinGen 1000Genomes ExAC gnomAD
CA400966082 rs1598663974	25	C>G		No	ClinGen Ensembl
rs751297310 CA8756414	26	P>R		No	ClinGen ExAC gnomAD
rs1205504916 CA400966106	27	R>C		No	ClinGen TOPMed gnomAD
CA400966102 rs1205504916	27	R>S		No	ClinGen TOPMed gnomAD
rs1255191179 CA400966122	29	A>T		No	ClinGen TOPMed gnomAD
CA400966158 rs1390601063	32	K>R		No	ClinGen TOPMed
CA8756417 rs150811008	33	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs755868899 CA8756418	33	Q>P		No	ClinGen ExAC gnomAD
CA400966171 rs755868899	33	Q>R		No	ClinGen ExAC gnomAD
CA8756420 rs777636056	35	D>H		No	ClinGen ExAC gnomAD
rs777636056 CA8756419	35	D>N		No	ClinGen ExAC gnomAD
rs1430618185 CA400966207	36	G>R		No	ClinGen gnomAD
rs747055781 CA8756424	38	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1302525108 CA400966236	38	E>G		No	ClinGen gnomAD
CA400966243 rs1398174886	39	F>I		No	ClinGen TOPMed gnomAD
rs1398174886 CA400966247	39	F>V		No	ClinGen TOPMed gnomAD
CA8756425 rs776855061	43	Y>C		No	ClinGen ExAC gnomAD
rs1161105204 CA400966288	43	Y>D		No	ClinGen TOPMed
CA293967602 rs909301492	44	S>N		No	ClinGen TOPMed
rs762091471 CA293967610	46	D>H		No	ClinGen ExAC TOPMed gnomAD
rs762091471 CA8756426	46	D>N		No	ClinGen ExAC TOPMed gnomAD
CA400966373 rs942067737	49	Y>*		No	ClinGen TOPMed
CA8756428 rs772866271	49	Y>H		No	ClinGen ExAC gnomAD
CA400966363 rs1228644245	49	Y>S		No	ClinGen gnomAD
rs763485977 CA400966376	50	P>A		No	ClinGen ExAC gnomAD
rs763485977 CA8756429	50	P>T		No	ClinGen ExAC gnomAD
CA400966391 rs1482125923	51	E>K		No	ClinGen gnomAD
rs1201976582 CA400966416	53	Q>E		No	ClinGen gnomAD
rs751133594 CA8756431	55	S>L		No	ClinGen ExAC gnomAD
rs1464376581 CA400966453	55	S>P		No	ClinGen gnomAD
rs754475699 CA8756432	56	D>H		No	ClinGen ExAC TOPMed gnomAD
CA400966466 rs754475699	56	D>N		No	ClinGen ExAC TOPMed gnomAD
CA293967630 rs1055301281	57	T>I		No	ClinGen TOPMed gnomAD
CA293967637 rs1055301281	57	T>N		No	ClinGen TOPMed gnomAD
TCGA novel	58	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400966591 rs1333725140	62	P>L		No	ClinGen TOPMed
CA400967551 rs1598667625	63	N>K		No	ClinGen Ensembl
CA293969170 rs955689559	63	N>S		No	ClinGen TOPMed gnomAD
CA400967600 rs1269864347	65	A>E		No	ClinGen gnomAD
CA400967599 rs1269864347	65	A>V		No	ClinGen gnomAD
rs1317444677 CA400967622	67	Q>*		No	ClinGen gnomAD
CA400967629 rs1220823906	67	Q>L		No	ClinGen gnomAD
CA8756456 rs770089302	69	D>H		No	ClinGen ExAC TOPMed gnomAD
rs770089302 CA8756455	69	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1311918581 CA775024999	71	D>E		No	ClinGen TOPMed
CA8756457 rs372764852	72	I>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA8756458 rs750357888	73	P>T		No	ClinGen ExAC TOPMed gnomAD
rs755111147 CA8756459	75	D>N		No	ClinGen ExAC gnomAD
CA293970058 rs747226298	76	R>C		No	ClinGen TOPMed gnomAD
rs753423038 CA8756474	76	R>H		No	ClinGen ExAC TOPMed gnomAD
rs753423038 CA400968952	76	R>P		No	ClinGen ExAC TOPMed gnomAD
CA8756475 VAR_024604 rs10512599	77	L>F		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1447045968 CA400969002	78	T>I		No	ClinGen TOPMed gnomAD
rs772439971 CA8756476	79	I>V		No	ClinGen ExAC TOPMed gnomAD
CA8756477 rs750398890	81	Y>S		No	ClinGen ExAC gnomAD
rs989525100 CA293970071	82	C>S		No	ClinGen TOPMed
CA293970073 rs915017410	82	C>Y		No	ClinGen TOPMed
rs779805621 CA8756479	83	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs376441798 CA8756478	83	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs573539375 CA293970082	84	S>G		No	ClinGen Ensembl
rs752835305 CA8756480	84	S>N		No	ClinGen ExAC gnomAD
rs147649597 CA400969173	86	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8756481 rs147649597	86	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs975845045 CA293970090	87	P>T		No	ClinGen Ensembl
rs771468987 CA8756485	88	G>A		No	ClinGen ExAC TOPMed gnomAD
rs778120165 CA8756484	88	G>R		No	ClinGen ExAC gnomAD
rs778120165 CA8756483	88	G>W		No	ClinGen ExAC gnomAD
rs746198873 CA8756487	89	G>R		No	ClinGen ExAC gnomAD
rs746252231 CA8756504	100	E>K		No	ClinGen ExAC gnomAD
rs1189137753 CA400969618	102	R>G		No	ClinGen gnomAD
rs758623580 CA8756505	104	H>Y		No	ClinGen ExAC gnomAD
rs1598670599 CA400969712	105	L>W		No	ClinGen Ensembl
CA293970327 rs1054491596	106	A>G		No	ClinGen TOPMed gnomAD
CA400969742 rs1598670607	107	T>P		No	ClinGen Ensembl
CA8756506 rs780678689	108	A>T		No	ClinGen ExAC gnomAD
rs1309157021 CA400969845	109	E>G		No	ClinGen TOPMed
CA8756508 rs768262701	109	E>K		No	ClinGen ExAC TOPMed gnomAD
rs747606400 CA8756510	110	W>C		No	ClinGen ExAC gnomAD
rs147301315 CA8756511	112	A>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs147301315 CA8756512	112	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM1210226 rs902063041 CA293970340	112	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
TCGA novel	113	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8756515 rs774392924	115	V>M		No	ClinGen ExAC TOPMed gnomAD
rs759359119 CA8756516	116	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1026483975 CA293970354	116	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs767525513 CA8756517	117	Q>E		No	ClinGen ExAC gnomAD
CA400970144 rs1218861833	119	I>R		No	ClinGen gnomAD
rs757357461 CA8756519	120	A>V		No	ClinGen ExAC gnomAD
VAR_061767 rs34496172 CA8756520	122	T>M		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA293970399 rs779973202	123	H>L		No	ClinGen Ensembl
rs1182379522 CA400970538	124	K>T		No	ClinGen gnomAD
CA293970404 rs201529363	125	N>S		No	ClinGen 1000Genomes ESP TOPMed gnomAD
CA400970593 CA400970589 rs1471815160	126	K>N		No	ClinGen gnomAD
rs774048391 CA8756533	131	G>*		No	ClinGen ExAC TOPMed gnomAD
CA8756535 rs767578922	133	L>F		No	ClinGen ExAC TOPMed gnomAD
CA293970441 rs928056809	135	L>H		No	ClinGen TOPMed
rs1598670859 CA400970807	136	T>P		No	ClinGen Ensembl
rs1399023089 CA400970830	137	S>Y		No	ClinGen gnomAD
rs1598670871 CA400970865	139	S>T		No	ClinGen Ensembl
CA400970878 rs1334007900	140	S>G		No	ClinGen TOPMed gnomAD
CA293970444 rs1052467377	140	S>N		No	ClinGen TOPMed
rs151335238 COSM4138161 CA8756539	141	R>C	pancreas [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs140592685 CA8756540	141	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs151335238 CA8756538	141	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM1316600 rs766571823 CA8756541	142	Y>*	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA8756542 rs370919315	143	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1359580925 CA400970943	143	Q>P		No	ClinGen TOPMed gnomAD
rs375880126 CA8756544	145	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs755268601 CA8756543	145	R>W		No	ClinGen ExAC TOPMed gnomAD
CA293970458 rs1044381552	148	A>T		No	ClinGen TOPMed
CA8756545 rs755018088	149	D>G		No	ClinGen ExAC TOPMed gnomAD
CA400971049 rs1440615914	150	C>G		No	ClinGen gnomAD
CA400971047 rs1440615914	150	C>R		No	ClinGen gnomAD
rs1262713189 CA400971122	155	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA8756546 rs144000860	155	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA293970475 rs770515306 CA8756549	157	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC TOPMed gnomAD NCI-TCGA
rs1029298033 CA293970471	157	M>K		No	ClinGen TOPMed
CA293970466 rs372813825	157	M>L		No	ClinGen ESP ExAC gnomAD
CA8756548 rs372813825	157	M>V		No	ClinGen ESP ExAC gnomAD
rs113914546 CA293970480	162	S>R		No	ClinGen TOPMed gnomAD
CA8756553 rs201288213	165	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA8756552 rs201288213	165	P>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs1455020298 CA400971314	165	P>S		No	ClinGen gnomAD
TCGA novel	168	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA400971398 rs1452774907	168	P>T		No	ClinGen TOPMed
CA293970492 rs8068910	170	K>*		No	ClinGen Ensembl
CA8756558 rs140917471	171	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1227780671	171	E>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1205443093 CA400972114	177	R>*		No	ClinGen gnomAD
CA400972131 rs1171568301	178	I>T		No	ClinGen TOPMed
rs1263692482 CA400972127	178	I>V		No	ClinGen gnomAD
rs751797695 CA8756560	179	R>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA8756562 rs759952365	179	R>K		No	ClinGen ExAC gnomAD
CA8756561 rs759952365	179	R>M		No	ClinGen ExAC gnomAD
rs1481587004 CA400972234	182	N>K		No	ClinGen gnomAD
CA8756580 rs775853675	183	M>T		No	ClinGen ExAC gnomAD
CA293970627 rs181264326	184	N>S		No	ClinGen 1000Genomes gnomAD
CA8756583 rs528370211	185	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8756584 rs528370211	185	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM984248 CA8756582 rs764514778	185	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1453883413 CA400972279	186	E>K		No	ClinGen gnomAD
CA8756585 rs764786457	187	R>G		No	ClinGen ExAC TOPMed gnomAD
CA8756586 rs375187085	187	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA293970635 rs35821818	188	L>V		No	ClinGen Ensembl
CA400972351 rs1406451235 COSM3421898	189	R>S	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1385759123 CA400972419	191	K>N		No	ClinGen TOPMed
CA400972426 rs1171210665	192	R>G		No	ClinGen TOPMed gnomAD
CA8756589 rs746802123	192	R>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	193	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754795020 CA8756590	193	I>V		No	ClinGen ExAC TOPMed gnomAD
rs781046033 CA8756592	194	H>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA8756591 rs781046033	194	H>Y		No	ClinGen ExAC gnomAD
CA8756593 rs770955106	195	S>F		No	ClinGen ExAC gnomAD
rs921482215 CA293970647	196	A>V		No	ClinGen TOPMed
rs1289771741 CA400972511	197	V>L		No	ClinGen gnomAD
CA293970649 rs932787730	201	R>S		No	ClinGen TOPMed gnomAD
rs1244820897 CA400972597	201	R>W		No	ClinGen TOPMed
rs1179414687 CA400972658	203	V>I		No	ClinGen gnomAD
CA400972678 rs772297258	204	D>H		No	ClinGen ExAC TOPMed gnomAD
rs772297258 CA8756596	204	D>N		No	ClinGen ExAC TOPMed gnomAD
CA400972719 rs1163443422	205	M>T		No	ClinGen gnomAD

No associated diseases with Q14197

1 regional properties for Q14197

Type	Name	Position	InterPro Accession
domain	Peptide chain release factor class I	69 - 201	IPR000352

Functions

		Description
EC Number	3.1.1.29	Carboxylic ester hydrolases
Subcellular Localization	Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
mitochondrial inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial large ribosomal subunit	The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).
mitochondrial matrix	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name	Definition
aminoacyl-tRNA hydrolase activity	Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.
translation release factor activity, codon nonspecific	A translation release factor that is not specific to particular codons; binds to guanine nucleotides.

2 GO annotations of biological process

Name	Definition
mitochondrial translation	The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.
mitochondrial translational termination	The process resulting in the release of a polypeptide chain from the ribosome in a mitochondrion, usually in response to a termination codon (note that mitochondria use variants of the universal genetic code that differ between different taxa).

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8R035	Mrpl58	Peptidyl-tRNA hydrolase ICT1, mitochondrial	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MAATRCLRWG	LSRAGVWLLP	PPARCPRRAL	HKQKDGTEFK	SIYSLDKLYP	ESQGSDTAWR
70	80	90	100	110	120
VPNGAKQADS	DIPLDRLTIS	YCRSSGPGGQ	NVNKVNSKAE	VRFHLATAEW	IAEPVRQKIA
130	140	150	160	170	180
ITHKNKINRL	GELILTSESS	RYQFRNLADC	LQKIRDMITE	ASQTPKEPTK	EDVKLHRIRI
190	200
ENMNRERLRQ	KRIHSAVKTS	RRVDMD