AiPD: Autoinhibited Protein Database

Q8NEM2

Gene name	SHCBP1
Protein name	SHC SH2 domain-binding protein 1
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:79801
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-82 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-82 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8NEM2

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8NEM2-F1	Predicted				AlphaFoldDB

515 variants for Q8NEM2

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA396090380 rs1218092183	2	A>S		No	ClinGen gnomAD
rs767753286 CA8036546	3	D>N		No	ClinGen ExAC gnomAD
rs759988033 CA396090368	4	G>R		No	ClinGen ExAC TOPMed gnomAD
CA8036545 rs759988033	4	G>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs774802723 CA396090361	5	S>*		No	ClinGen ExAC TOPMed gnomAD
rs774802723 CA8036544	5	S>L		No	ClinGen ExAC TOPMed gnomAD
rs774802723 CA396090360	5	S>W		No	ClinGen ExAC TOPMed gnomAD
rs1567457394 CA396090357	6	L>Q		No	ClinGen Ensembl
rs1298508955 CA396090359	6	L>V		No	ClinGen gnomAD
CA396090349 rs1226469453	7	T>M		No	ClinGen gnomAD
CA396090350 rs1226469453	7	T>R		No	ClinGen gnomAD
CA396090339 rs1320223317	9	G>D		No	ClinGen gnomAD
rs1262847028 CA720990767	9	G>R		No	ClinGen TOPMed
rs1320223317 CA396090337	9	G>V		No	ClinGen gnomAD
TCGA novel	10	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8036540 rs776119732	10	G>D		No	ClinGen ExAC TOPMed gnomAD
CA396090336 rs1363863229	10	G>S		No	ClinGen TOPMed gnomAD
CA280431902 rs776119732	10	G>V		No	ClinGen ExAC TOPMed gnomAD
CA8036539 rs768274909	11	L>R		No	ClinGen ExAC TOPMed gnomAD
CA8036537 rs144267302	13	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1475298663 CA396090320	13	A>T		No	ClinGen gnomAD
CA8036536 rs144267302	13	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA396090315 rs1472538193	14	A>P		No	ClinGen TOPMed gnomAD
CA8036533 rs553357867	14	A>V		No	ClinGen 1000Genomes ExAC gnomAD
CA280431828 rs140408371	15	A>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8036532 rs140408371	15	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA396090304 rs1222619858 CA396090302	16	M>I		No	ClinGen TOPMed gnomAD
rs995656608 CA280431805	16	M>K		No	ClinGen TOPMed
CA8036530 rs147549440 CA8036531	16	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA8036529 rs147549440	16	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1452938789 CA396090301	17	A>T		No	ClinGen gnomAD
CA8036528 rs752832808	17	A>V		No	ClinGen ExAC TOPMed gnomAD
rs755251087 CA8036526	18	P>L		No	ClinGen ExAC TOPMed gnomAD
rs767814496 CA8036527	18	P>S		No	ClinGen ExAC gnomAD
CA396090292 rs1221655735	19	E>K		No	ClinGen gnomAD
CA396090279 rs1253822791	20	R>L		No	ClinGen gnomAD
CA280431788 rs17856883 CA8036523	21	M>I		No	ClinGen ExAC TOPMed gnomAD
CA8036525 rs6598679	21	M>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8036524 VAR_051354 rs6598679	21	M>T		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA8036522 rs773761609	23	W>R		No	ClinGen ExAC TOPMed gnomAD
CA8036521 rs763486870	24	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1435669827 CA396090250	25	V>A		No	ClinGen TOPMed
rs1397701103 CA396090252	25	V>L		No	ClinGen gnomAD
CA396090242 rs1483750245	26	E>D		No	ClinGen TOPMed
rs1468651839 CA396090245	26	E>G		No	ClinGen TOPMed gnomAD
CA280431772 rs1008703403	26	E>K		No	ClinGen TOPMed
CA8036519 rs377365467	27	Q>E		No	ClinGen ESP ExAC gnomAD
CA8036518 rs377365467	27	Q>K		No	ClinGen ESP ExAC gnomAD
rs1199428685 CA396090239	27	Q>R		No	ClinGen gnomAD
CA8036517 rs745599323	28	E>*		No	ClinGen ExAC gnomAD
CA280431760 rs111694311	28	E>G		No	ClinGen Ensembl
CA396090235 rs745599323	28	E>K		No	ClinGen ExAC gnomAD
CA396090234 rs745599323	28	E>Q		No	ClinGen ExAC gnomAD
CA8036516 rs774284933	29	L>V		No	ClinGen ExAC gnomAD
rs770908710 CA8036515	32	L>P		No	ClinGen ExAC TOPMed gnomAD
CA396090205 rs1259809039	33	E>G		No	ClinGen gnomAD
CA280430245 rs78630461	35	G>V		No	ClinGen Ensembl
rs79790675 CA280430239	36	L>F		No	ClinGen Ensembl
CA280430236 rs980745275	37	F>L		No	ClinGen TOPMed
rs781332172 CA8036488	41	D>E		No	ClinGen ExAC TOPMed gnomAD
rs896409342 CA280430235	41	D>V		No	ClinGen Ensembl
TCGA novel	43	C>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs992649575 CA280430211	44	S>G		No	ClinGen TOPMed gnomAD
rs758719965 CA280430209	46	C>F		No	ClinGen ExAC TOPMed gnomAD
CA8036485 rs780292870	46	C>G		No	ClinGen ExAC gnomAD
rs780292870 CA8036486	46	C>R		No	ClinGen ExAC gnomAD
CA8036484 rs758719965	46	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA8036483 rs750821378	49	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1381765742 CA396090077	49	R>H		No	ClinGen gnomAD
CA396090078 rs750821378	49	R>S		No	ClinGen ExAC TOPMed gnomAD
rs779228165 CA8036482	52	P>T		No	ClinGen ExAC gnomAD
CA8036481 RCV000894223 rs76534624	54	S>C		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA8036479 rs139554699	60	M>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA8036480 rs11545690 VAR_051355	60	M>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1462446634 CA396089991	61	P>L		No	ClinGen TOPMed
CA8036477 rs751217741	64	K>E		No	ClinGen ExAC gnomAD
CA280430195 rs201984083	64	K>R		No	ClinGen 1000Genomes
CA8036476 rs568809430	65	T>S		No	ClinGen 1000Genomes ExAC
rs762780620 CA8036474	66	F>L		No	ClinGen ExAC TOPMed gnomAD
rs146004470 CA8036473	67	F>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1488694147 CA396089946	68	P>L		No	ClinGen gnomAD
rs1288424865 CA396089945	69	E>K		No	ClinGen gnomAD
rs1596692591 CA396089929	71	F>I		No	ClinGen Ensembl
CA8036472 rs769546343	72	Q>H		No	ClinGen ExAC gnomAD
rs1184650492 CA396089917	72	Q>R		No	ClinGen TOPMed gnomAD
CA8036471 rs761792845	75	Q>K		No	ClinGen ExAC gnomAD
rs1432943783 CA396089892	76	L>F		No	ClinGen TOPMed
CA280430168 rs945146766	79	Y>C		No	ClinGen TOPMed gnomAD
CA396089870 rs945146766	79	Y>S		No	ClinGen TOPMed gnomAD
CA8036468 rs747121194	81	R>*		No	ClinGen ExAC TOPMed gnomAD
rs772293350 CA8036467	81	R>P		No	ClinGen ExAC TOPMed gnomAD
CA8036466 rs772293350	81	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA396089848 rs1423549063	83	R>G		No	ClinGen gnomAD
TCGA novel	83	R>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396089837 rs1365840102	84	A>G		No	ClinGen gnomAD
rs1253203446 CA396089841	84	A>T		No	ClinGen TOPMed
CA8036464 rs200068397	85	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs1426536565 CA396089824	86	Q>R		No	ClinGen gnomAD
CA8036463 rs189131703	88	Y>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8036462 rs201168675	89	I>V		No	ClinGen ExAC TOPMed
TCGA novel	90	L>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs201101866 CA8036444	91	A>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs201101866 CA8036443	91	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1467075279 CA396089774	92	D>A		No	ClinGen gnomAD
rs772205443 CA8036441	92	D>H		No	ClinGen ExAC gnomAD
rs772205443 CA8036442	92	D>N		No	ClinGen ExAC gnomAD
rs1291101706 CA396089765	93	C>Y		No	ClinGen gnomAD
rs746080661 CA8036440	94	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA396089753 rs1240437635	95	A>P		No	ClinGen TOPMed
CA280429564 rs992911878	97	E>D		No	ClinGen TOPMed gnomAD
rs369047561 CA8036438	99	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs749639882 CA8036437	99	Q>L		No	ClinGen ExAC TOPMed gnomAD
CA8036436 rs778369901	105	F>L		No	ClinGen ExAC gnomAD
CA8036434 rs748735561	106	L>S		No	ClinGen ExAC gnomAD
rs761201254 CA280429551	112	P>L		No	ClinGen TOPMed gnomAD
rs1324869949 CA396089627	114	G>R		No	ClinGen TOPMed
CA396089615 rs1324168184	115	W>*		No	ClinGen TOPMed
rs372268527 CA8036432	116	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
COSM3361767 CA8036433 rs779702179	116	R>W	kidney [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1045374791 CA280429530	117	A>V		No	ClinGen TOPMed
rs1012470827 CA280429501	120	H>Y		No	ClinGen TOPMed
rs1335642118 CA396089575	122	N>D		No	ClinGen TOPMed
rs764826820 CA8036429	122	N>K		No	ClinGen ExAC gnomAD
CA396089546 rs757026436	126	V>L		No	ClinGen ExAC TOPMed gnomAD
rs757026436 CA8036427	126	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1446475231 CA396089541	127	L>V		No	ClinGen TOPMed
rs1448725426 CA396089537	128	V>I		No	ClinGen gnomAD
CA8036415 rs770344569	130	I>F		No	ClinGen ExAC TOPMed gnomAD
CA396089350 rs770344569	130	I>L		No	ClinGen ExAC TOPMed gnomAD
CA396089351 rs770344569	130	I>V		No	ClinGen ExAC TOPMed gnomAD
rs781773628 CA8036413	132	D>N		No	ClinGen ExAC gnomAD
CA8036412 rs368228161	133	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA8036411 rs142000194	137	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1304588863 CA396089280	140	A>V		No	ClinGen gnomAD
rs1327299410 CA396089265	143	R>K		No	ClinGen gnomAD
rs756862260 CA8036408	147	P>S		No	ClinGen ExAC gnomAD
CA396089240 rs756862260	147	P>T		No	ClinGen ExAC gnomAD
rs763862767 CA8036406	149	L>F		No	ClinGen ExAC gnomAD
CA396089227 rs763862767	149	L>V		No	ClinGen ExAC gnomAD
rs1258878832 CA396089202	152	S>C		No	ClinGen gnomAD
rs1202797558 CA396089200	153	Q>K		No	ClinGen gnomAD
rs1485293574 CA396089183	155	S>N		No	ClinGen gnomAD
CA280428445 rs923258497	156	T>A		No	ClinGen Ensembl
CA8036405 rs755951635	158	T>I		No	ClinGen ExAC gnomAD
TCGA novel	160	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8036403 rs767379401	162	M>L		No	ClinGen ExAC gnomAD
CA8036402 rs759604344	162	M>T		No	ClinGen ExAC gnomAD
CA396089135 rs767379401	162	M>V		No	ClinGen ExAC gnomAD
CA8036401 rs774301993	164	E>K		No	ClinGen ExAC TOPMed gnomAD
CA396089106 rs1380602301	166	L>F		No	ClinGen gnomAD
rs1041021873 CA280428399	167	D>Y		No	ClinGen Ensembl
rs942573950 CA280428388	168	L>V		No	ClinGen TOPMed gnomAD
rs928144028 CA280428385	170	E>Q		No	ClinGen TOPMed
CA280428375 rs866698459	171	H>N		No	ClinGen gnomAD
CA8036398 rs773621044	172	R>Q		No	ClinGen ExAC gnomAD
CA8036399 rs763257855	172	R>W		No	ClinGen ExAC gnomAD
CA396089057 rs1363980445	174	P>A		No	ClinGen gnomAD
rs1363980445 CA396089056	174	P>S		No	ClinGen gnomAD
CA280428356 rs113749182	177	E>G		No	ClinGen Ensembl
rs1214960418 CA396089026	179	W>R		No	ClinGen Ensembl
CA396089014 rs1596690645	180	V>G		No	ClinGen Ensembl
CA280428353 rs146106817	180	V>M		No	ClinGen ESP
rs1596690637 CA396089008	181	V>G		No	ClinGen Ensembl
rs1477196441 CA396088992	183	D>E		No	ClinGen gnomAD
rs777226287 CA8036395	185	S>A		No	ClinGen ExAC gnomAD
rs966837603 CA280428312	189	D>E		No	ClinGen TOPMed
CA8036393 rs745308205	191	T>I		No	ClinGen ExAC gnomAD
rs952511681 CA280428287	195	I>M		No	ClinGen gnomAD
CA8036392 rs367816466	195	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA280428272 rs867427829	199	R>I		No	ClinGen Ensembl
CA8036381 rs750630198	202	Y>C		No	ClinGen ExAC gnomAD
CA396088838 rs34559393	204	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1438905489 CA396088836	205	I>V		No	ClinGen TOPMed
CA396088824 rs1274461198	206	W>*		No	ClinGen gnomAD
rs771517898 CA280423636	208	S>N		No	ClinGen Ensembl
CA396088790 rs1338828662	211	E>K		No	ClinGen TOPMed
TCGA novel	212	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8036379 rs143807959	215	D>Y		No	ClinGen ESP ExAC gnomAD
rs776862098 CA8036378	216	E>K		No	ClinGen ExAC gnomAD
CA396088742 rs1260534560	217	Y>D		No	ClinGen TOPMed
CA396088743 rs1260534560	217	Y>H		No	ClinGen TOPMed
CA8036376 rs761071900	218	D>N		No	ClinGen ExAC gnomAD
CA8036374 rs376538138	221	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA8036373 rs376538138	221	V>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs776113874 CA8036375	221	V>I		No	ClinGen ExAC TOPMed gnomAD
CA396088702 rs1200594001	223	C>R		No	ClinGen TOPMed
rs769443227 CA8036371	223	C>S		No	ClinGen ExAC gnomAD
CA280423547 rs747865264	226	P>L		No	ClinGen ExAC TOPMed gnomAD
CA8036370 rs747865264	226	P>R		No	ClinGen ExAC TOPMed gnomAD
COSM970757 rs780839550 CA8036369	227	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1458095374 CA396088663	229	R>I		No	ClinGen gnomAD
rs1406415052 CA396088635	231	H>R		No	ClinGen TOPMed
CA396088627 rs1472385994	232	Y>C		No	ClinGen gnomAD
CA396088630 rs1397251298	232	Y>H		No	ClinGen TOPMed
rs762124697 CA8036360	234	I>T		No	ClinGen ExAC
CA8036359 rs749245057	236	E>D		No	ClinGen ExAC TOPMed gnomAD
rs370810038 CA280421191	237	D>E		No	ClinGen ESP TOPMed
CA8036358 rs764345009	238	R>*	Variant assessed as Somatic; 4.626e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8036357 rs761142529	238	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA8036356 rs775811918	244	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1222710736 CA396088549	245	V>I		No	ClinGen TOPMed
rs768024463 CA8036355	246	D>H		No	ClinGen ExAC gnomAD
rs1263961580 CA396088536	247	Y>H		No	ClinGen TOPMed
CA396088529 rs1379008591	248	H>N		No	ClinGen gnomAD
CA396088527 rs1379008591	248	H>Y		No	ClinGen gnomAD
CA280421176 rs777927592	249	N>H		No	ClinGen Ensembl
CA8036353 rs772703007	249	N>S		No	ClinGen ExAC TOPMed gnomAD
rs769349334 CA8036352	250	L>R		No	ClinGen ExAC TOPMed gnomAD
CA8036351 rs747730910	254	C>R		No	ClinGen ExAC TOPMed gnomAD
CA8036350 rs776383201	256	E>G		No	ClinGen ExAC gnomAD
CA396088473 rs1297179923	256	E>K		No	ClinGen gnomAD
rs1161372409 CA396088448	259	R>M		No	ClinGen gnomAD
TCGA novel	260	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396088421 rs1423088335	263	N>D		No	ClinGen gnomAD
CA396088417 rs1414439853	263	N>I		No	ClinGen gnomAD
CA396088406 rs1438840438	265	R>T		No	ClinGen TOPMed
CA396088376 rs1183567100	269	S>*		No	ClinGen gnomAD
CA280421152 rs961348785	270	N>D		No	ClinGen TOPMed
CA396088354 rs1473804082	272	N>S		No	ClinGen gnomAD
CA396088346 rs1267462296	273	S>C		No	ClinGen TOPMed
rs1221524765 CA396088330	276	E>K		No	ClinGen TOPMed
rs1396748438 CA396088314	278	E>K		No	ClinGen gnomAD
rs1021341991 CA280421092	281	S>P		No	ClinGen Ensembl
rs373701887 CA8036345	282	M>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1219814107 CA396088277	283	V>M		No	ClinGen gnomAD
TCGA novel	285	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1291182534 CA396088256	286	L>*		No	ClinGen gnomAD
rs1339131551 CA396088231	289	Y>F		No	ClinGen TOPMed gnomAD
rs138864591 CA8036343	290	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1341969352 CA396088214	292	M>V		No	ClinGen gnomAD
CA8036341 rs201494848	293	E>*		No	ClinGen 1000Genomes ExAC gnomAD
CA396088205 rs201494848	293	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs764408135 CA280421027	294	Q>L		No	ClinGen ExAC gnomAD
rs764408135 CA8036340	294	Q>R		No	ClinGen ExAC gnomAD
CA396088186 rs1199996970	296	K>Q		No	ClinGen gnomAD
rs756375959 CA396088177	297	Q>*		No	ClinGen ExAC gnomAD
rs756375959 CA8036339	297	Q>E		No	ClinGen ExAC gnomAD
rs1030134493 CA280421009	298	K>R		No	ClinGen TOPMed
rs1030134493 CA396088168	298	K>T		No	ClinGen TOPMed
rs753109291 CA8036338	301	L>F		No	ClinGen ExAC TOPMed gnomAD
rs753109291 CA396088150	301	L>V		No	ClinGen ExAC TOPMed gnomAD
CA396088143 rs1481360533	302	I>T		No	ClinGen TOPMed gnomAD
CA396088136 rs1251024992	303	E>A		No	ClinGen TOPMed
TCGA novel	304	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767934484 CA8036337	306	L>S		No	ClinGen ExAC gnomAD
CA8036336 rs760020240	307	L>M		No	ClinGen ExAC gnomAD
CA396088071 rs1238069557	311	F>I		No	ClinGen gnomAD
rs868729387 CA280420858	312	G>D		No	ClinGen Ensembl
CA8036317 rs752918531	313	Y>C		No	ClinGen ExAC gnomAD
TCGA novel	314	Q>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396088036 rs1359270924	315	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA396088006 rs1567449509	320	Q>K		No	ClinGen Ensembl
CA396088002 rs1253701419	320	Q>R		No	ClinGen gnomAD
CA396087998 rs1231898743	321	A>T		No	ClinGen gnomAD
CA396087973 rs1223905190	324	V>G		No	ClinGen TOPMed
CA8036316 rs767842642 COSM1377940	325	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs375185810 CA8036315	327	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs766889570 COSM241600 CA8036313	328	G>S	prostate [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1051810165 CA280420833	331	I>L		No	ClinGen TOPMed
rs199914265 CA280420828	332	T>I		No	ClinGen Ensembl
CA396087917 rs1449729753	333	H>L		No	ClinGen TOPMed
rs201568619 CA8036311	337	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA396087865 rs1448842558	341	A>S		No	ClinGen gnomAD
CA396087857 rs1337905276	342	G>A		No	ClinGen TOPMed gnomAD
CA396087853 rs1400022590	343	L>I		No	ClinGen gnomAD
rs200589685 CA8036308	345	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs763581676 CA8036309	345	R>W		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	347	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8036306 rs771963584	348	L>V		No	ClinGen ExAC TOPMed gnomAD
COSM3420993 rs199982006 CA8036305	349	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA
rs538774624 CA8036304	351	R>G		No	ClinGen 1000Genomes ExAC gnomAD
CA396087807 rs1254704041	351	R>S		No	ClinGen gnomAD
CA396087806 rs1383010372	352	L>I		No	ClinGen Ensembl
CA8036303 rs770906199	353	C>F		No	ClinGen ExAC gnomAD
CA396087799 rs1199375603	353	C>R		No	ClinGen TOPMed gnomAD
rs376727147 CA8036302	354	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA8036301 rs369036517	354	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA396087783 rs1309666717	355	E>A		No	ClinGen gnomAD
CA8036300 rs199576557	355	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA280420706 rs969691104	356	P>L		No	ClinGen TOPMed gnomAD
CA280420703 rs1022670170	357	G>S		No	ClinGen TOPMed
CA396087771 COSM3667854 rs1338611903	357	G>V	liver [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1311999344 CA396087752	360	E>*		No	ClinGen gnomAD
CA8036299 rs748335934	364	Q>R		No	ClinGen ExAC gnomAD
CA8036280 rs769874421	366	H>R		No	ClinGen ExAC gnomAD
rs1194937551 CA396087688	367	S>G		No	ClinGen TOPMed gnomAD
rs1244043761 CA396087686	367	S>N		No	ClinGen gnomAD
rs781330593 CA8036278	367	S>R		No	ClinGen ExAC gnomAD
CA396087672 rs1478266017	369	P>S		No	ClinGen TOPMed
rs1417686529 CA396087665	370	L>S		No	ClinGen TOPMed
rs768875072 CA8036277	372	A>V		No	ClinGen ExAC gnomAD
rs147585883 CA8036276	373	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA396087635 rs1169329116	375	A>T		No	ClinGen TOPMed
CA396087620 rs1256146680	377	F>L		No	ClinGen gnomAD
CA396087615 rs758741836	377	F>L		No	ClinGen ExAC TOPMed gnomAD
CA8036273 rs750913417	378	E>K		No	ClinGen ExAC gnomAD
CA280420369 rs771133626	380	D>E		No	ClinGen Ensembl
rs1350807479 CA396087593	381	T>A		No	ClinGen TOPMed
CA8036272 rs779320266	382	V>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	383	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA280420349 rs1055421432	385	C>*		No	ClinGen Ensembl
CA280420331 rs140069841	387	G>A		No	ClinGen ESP TOPMed gnomAD
CA396087553 rs140069841	387	G>D		No	ClinGen ESP TOPMed gnomAD
rs752268440 CA8036270	388	H>P		No	ClinGen ExAC gnomAD
rs752268440 CA8036271	388	H>R		No	ClinGen ExAC gnomAD
CA280420325 rs749439950	390	V>A		No	ClinGen Ensembl
CA8036268 rs754663698	390	V>M		No	ClinGen ExAC gnomAD
rs1329956842 CA396087534	391	V>I		No	ClinGen gnomAD
rs1329956842 CA396087533	391	V>L		No	ClinGen gnomAD
CA396087524 rs1464625670	392	H>R		No	ClinGen gnomAD
rs1220132313 CA396087517	393	G>D		No	ClinGen TOPMed
rs1344169223 CA396087518	393	G>S		No	ClinGen TOPMed
CA396087513 rs1353226629	394	T>A		No	ClinGen TOPMed gnomAD
CA280420324 rs968834473	396	S>T		No	ClinGen TOPMed
rs766166114 CA8036266	396	S>Y		No	ClinGen ExAC gnomAD
CA396087463 rs1169174640	401	I>M		No	ClinGen gnomAD
rs762684042 CA8036265	402	E>G		No	ClinGen ExAC gnomAD
CA280418226 rs1015227821	407	G>C		No	ClinGen gnomAD
TCGA novel	408	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1239891587 CA396087398	409	P>L		No	ClinGen gnomAD
rs761730635 CA8036243	410	D>G		No	ClinGen ExAC gnomAD
rs1461560245 CA396087396	410	D>H		No	ClinGen TOPMed
CA280418209 rs907424955	411	D>G		No	ClinGen gnomAD
CA280418213 rs1003144200	411	D>N		No	ClinGen TOPMed gnomAD
CA8036242 rs776601536	412	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1334272718 CA396087378	413	V>M		No	ClinGen gnomAD
rs1436155579 CA396087370	414	I>L		No	ClinGen gnomAD
rs1429707771 CA396087357	416	K>Q		No	ClinGen TOPMed
CA8036240 CA396087344 rs200482042	417	R>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8036239 rs373336645	418	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	419	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1420142921 CA396087325	420	G>V		No	ClinGen gnomAD
CA280418145 rs376160881 COSM471731	421	D>N	kidney [Cosmic]	No	ClinGen cosmic curated ESP TOPMed gnomAD
rs1230109797 CA396087305	423	F>L		No	ClinGen TOPMed
CA8036237 rs746177302	424	V>M		No	ClinGen ExAC TOPMed gnomAD
rs774564825 CA8036236	428	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA396087275 rs1236933520	428	G>R		No	ClinGen TOPMed gnomAD
rs771471109 CA8036235	429	A>V		No	ClinGen ExAC gnomAD
CA8036234 rs749780017	430	D>N		No	ClinGen ExAC gnomAD
CA396087266 rs749780017	430	D>Y		No	ClinGen ExAC gnomAD
rs1317941657 CA396087257	431	I>F		No	ClinGen TOPMed gnomAD
rs1286930287 CA396087253	431	I>M		No	ClinGen gnomAD
CA8036233 rs778453932	433	I>V		No	ClinGen ExAC TOPMed gnomAD
rs746511129 CA396087235	434	S>*		No	ClinGen ExAC gnomAD
CA8036231 rs746511129	434	S>L		No	ClinGen ExAC gnomAD
rs1337949733 CA396087231	435	G>D		No	ClinGen gnomAD
CA280418109 rs151148850	435	G>S		No	ClinGen ESP TOPMed gnomAD
rs1596678971 CA396087210	438	F>S		No	ClinGen Ensembl
CA396087199 rs1400355591	440	Q>K		No	ClinGen gnomAD
rs757985863 CA8036229	441	H>Y		No	ClinGen ExAC gnomAD
CA396087178 rs1475210675	442	D>E		No	ClinGen TOPMed
CA8036228 rs142201278	442	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs778659019 CA8036227	443	A>V		No	ClinGen ExAC gnomAD
rs1165731573 CA396087171	444	V>L		No	ClinGen TOPMed gnomAD
rs373935568 CA8036226	445	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA8036225 rs753737111	446	G>R		No	ClinGen ExAC gnomAD
CA396087124 rs1450877803	449	I>T		No	ClinGen TOPMed
rs759691750 CA8036200	450	V>I		No	ClinGen ExAC TOPMed gnomAD
CA8036199 rs751782063	452	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8036198 rs766719161	452	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	452	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8036197 rs763340134	454	K>R		No	ClinGen ExAC TOPMed gnomAD
CA280414798 rs926930869	456	T>A		No	ClinGen gnomAD
rs773704460 CA8036196	456	T>M		No	ClinGen ExAC TOPMed gnomAD
rs770254582 CA8036195	457	L>V		No	ClinGen ExAC TOPMed gnomAD
rs202030254 CA280414776	458	E>K		No	ClinGen Ensembl
rs1567445493 CA396087069	459	N>D		No	ClinGen Ensembl
rs762208281 CA8036194	460	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs1356492731 CA396087055	461	V>M		No	ClinGen gnomAD
CA8036191 rs745407076	468	G>R		No	ClinGen ExAC gnomAD
CA8036190 rs778481033	469	V>I		No	ClinGen ExAC gnomAD
TCGA novel	471	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8036189 rs535052871	472	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1177268431 CA396086985	472	R>W		No	ClinGen TOPMed gnomAD
CA396086971 rs1253862222	474	S>L		No	ClinGen gnomAD
rs777521264 CA8036187	477	F>L		No	ClinGen ExAC gnomAD
CA396086948 rs1596675875	478	L>V		No	ClinGen Ensembl
CA280414735 rs369921811	480	K>M		No	ClinGen ESP TOPMed gnomAD
rs372325367 CA280414720	480	K>N		No	ClinGen ESP TOPMed gnomAD
CA280414734 rs369921811	480	K>R		No	ClinGen ESP TOPMed gnomAD
rs1009622540 CA396086927	481	N>S		No	ClinGen gnomAD
rs1009622540 CA280414714	481	N>T		No	ClinGen gnomAD
rs777914584 CA280414706	482	S>L		No	ClinGen TOPMed gnomAD
CA8036185 rs747993306	485	Y>C		No	ClinGen ExAC gnomAD
rs756162190 COSM189213 CA8036183	487	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs751692076 CA8036182	488	K>*		No	ClinGen ExAC gnomAD
TCGA novel	488	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8036162 rs758593884	489	G>D		No	ClinGen ExAC gnomAD
CA8036161 rs750638471	490	A>T		No	ClinGen ExAC gnomAD
rs1191130374 CA396086856	490	A>V		No	ClinGen gnomAD
CA396086853 rs1446093064	491	G>C		No	ClinGen gnomAD
TCGA novel	491	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765522953 CA8036160	492	I>V		No	ClinGen ExAC gnomAD
rs1206683338 CA396086834	494	I>V		No	ClinGen gnomAD
rs757507035 CA8036159	497	G>W		No	ClinGen ExAC
rs754235384 CA8036157	498	S>C		No	ClinGen ExAC TOPMed gnomAD
rs754235384 CA396086809	498	S>G		No	ClinGen ExAC TOPMed gnomAD
CA8036156 rs764435122	498	S>N		No	ClinGen ExAC gnomAD
CA280407710 rs764435122	498	S>T		No	ClinGen ExAC gnomAD
CA8036154 rs776015484	499	Q>*		No	ClinGen ExAC gnomAD
CA396086793 rs1386150288	500	C>R		No	ClinGen TOPMed
CA396086784 rs1326079025	501	T>S		No	ClinGen gnomAD
TCGA novel	502	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA280407704 COSM970751 rs890860367	504	D>E	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1353002440 CA396086761	504	D>V		No	ClinGen TOPMed
TCGA novel	505	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396086753 rs772681234	505	N>K		No	ClinGen ExAC gnomAD
rs375325538 COSM4129077 CA8036149	506	G>E	thyroid [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs769488772 CA8036150	506	G>R		No	ClinGen ExAC gnomAD
rs1474841592 CA396086741	507	I>S		No	ClinGen gnomAD
rs367554354 CA8036147	508	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs746914623 CA8036146	509	H>Y		No	ClinGen ExAC gnomAD
rs566050581 CA8036143	514	I>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8036142 rs745961632	516	I>F		No	ClinGen ExAC gnomAD
CA396086656 rs1373167560	518	D>N		No	ClinGen TOPMed
rs1174006547 CA396086633	521	D>N		No	ClinGen gnomAD
rs1467057527 CA396086622	522	E>G		No	ClinGen TOPMed
rs1436399213 CA396086615	523	H>Y		No	ClinGen gnomAD
CA396086606 rs1378398042	524	Y>C		No	ClinGen gnomAD
CA280407556 rs889997673	524	Y>H		No	ClinGen TOPMed
TCGA novel	525	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA280407525 rs1050309727	528	K>N		No	ClinGen TOPMed gnomAD
CA396086574 rs1184110531	529	I>L		No	ClinGen gnomAD
rs772141428 CA8036125	531	M>V		No	ClinGen ExAC gnomAD
CA396086548 rs1360082124	532	V>G		No	ClinGen TOPMed
CA396086528 rs1223654447	535	I>T		No	ClinGen TOPMed gnomAD
rs779039839 CA8036123	535	I>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	536	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396086521 rs1320179213	536	I>T		No	ClinGen TOPMed
CA396086524 rs1352076690	536	I>V		No	ClinGen gnomAD
CA396086506 rs1280738468	538	N>S		No	ClinGen gnomAD
CA396086498 rs1412437688	539	N>S		No	ClinGen gnomAD
CA396086488 rs1352212111	540	E>D		No	ClinGen Ensembl
CA8036122 rs770967098	541	G>S		No	ClinGen ExAC TOPMed gnomAD
CA8036121 rs749485656	544	V>A		No	ClinGen ExAC TOPMed gnomAD
CA280407486 rs940026008	549	P>L		No	ClinGen TOPMed gnomAD
CA396086429 rs1410140284	550	T>A		No	ClinGen gnomAD
rs1453666822 CA396086427	550	T>I		No	ClinGen Ensembl
rs781600425 CA8036117	551	I>T		No	ClinGen ExAC gnomAD
rs753064628 CA8036118	551	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1417402433 CA396086401	554	D>G		No	ClinGen gnomAD
CA396086380 rs1281252386	557	E>G		No	ClinGen gnomAD
rs17856884 CA280407479	558	N>S		No	ClinGen Ensembl
rs546451151 CA8036115	560	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA8036114 rs764770611	561	D>G		No	ClinGen ExAC TOPMed gnomAD
CA8036113 rs368639897	562	G>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA396086343 rs1448059221	563	T>A		No	ClinGen gnomAD
rs1215040098 CA396086294	568	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA8036097 COSM970749 rs755336529	568	A>V	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA8036095 rs780451306	570	K>E		No	ClinGen ExAC gnomAD
rs1363745752 CA396086258	573	T>K		No	ClinGen gnomAD
rs1440030264 CA396086237	576	E>G		No	ClinGen TOPMed gnomAD
CA8036094 rs756738269	576	E>K		No	ClinGen ExAC gnomAD
rs1198855878 CA396086229	577	P>R		No	ClinGen gnomAD
CA396086205 rs1432986828	581	E>K		No	ClinGen TOPMed
CA280406971 rs1051754660	583	V>E		No	ClinGen TOPMed
CA8036090 rs755815445	586	E>K		No	ClinGen ExAC gnomAD
rs752448168 CA8036089	588	L>V		No	ClinGen ExAC TOPMed gnomAD
rs767390754 CA8036088	589	I>T		No	ClinGen ExAC TOPMed gnomAD
CA280406944 rs933949248	589	I>V		No	ClinGen TOPMed
rs1376709716 CA396086146	590	E>Q		No	ClinGen TOPMed
rs1445561242 CA396086125	593	T>A		No	ClinGen TOPMed
rs759269642 CA8036087	597	E>*		No	ClinGen ExAC gnomAD
CA280406941 rs749239219	600	A>S		No	ClinGen TOPMed
CA396086072 rs1454179094	600	A>V		No	ClinGen gnomAD
rs1254228654 CA396086071	601	R>G		No	ClinGen gnomAD
rs932581951 CA396086051	603	D>E		No	ClinGen TOPMed
CA396086040 rs1277327601	605	S>F		No	ClinGen TOPMed
rs774284671 CA8036086	605	S>T		No	ClinGen ExAC gnomAD
CA8036085 rs766231303	606	E>G		No	ClinGen ExAC gnomAD
CA8036084 rs763013061	607	Q>E		No	ClinGen ExAC gnomAD
TCGA novel	607	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA396086028 rs1204699990	607	Q>R		No	ClinGen gnomAD
rs748336053 CA8036081	612	C>F		No	ClinGen ExAC gnomAD
rs779118681 CA280406922	612	C>G		No	ClinGen Ensembl
rs748336053 CA396085994	612	C>Y		No	ClinGen ExAC gnomAD
CA396085980 rs1212236330	614	I>T		No	ClinGen TOPMed
rs149596699 CA8036079	619	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA8036076 rs146732663	623	T>K		No	ClinGen 1000Genomes ExAC
CA396085917 rs1372664014	624	Q>R		No	ClinGen gnomAD
CA396085885 rs1260679769	628	I>M		No	ClinGen TOPMed gnomAD
rs909651992 CA280406902	628	I>T		No	ClinGen Ensembl
CA280406900 rs965138116	629	K>R		No	ClinGen TOPMed
TCGA novel	630	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs777400573 CA8036073	633	L>*		No	ClinGen ExAC TOPMed gnomAD
rs777400573 CA396085852	633	L>S		No	ClinGen ExAC TOPMed gnomAD
rs1567440186 CA396085853	633	L>V		No	ClinGen Ensembl
rs755727601 CA8036072	635	E>D		No	ClinGen ExAC gnomAD
CA8036071 rs138129923	636	L>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8036070 rs767089061	638	I>N		No	ClinGen ExAC gnomAD
CA396085820 rs767089061	638	I>S		No	ClinGen ExAC gnomAD
rs370886430 CA396085813	639	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA8036069 rs370886430	639	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	639	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs766254686 CA8036067	641	A>T		No	ClinGen ExAC gnomAD
CA8036066 rs762773714	642	D>N		No	ClinGen ExAC TOPMed gnomAD
rs374314490 CA396085786	643	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1372390801 CA396085779	644	N>I		No	ClinGen TOPMed gnomAD
rs1372390801 CA396085780	644	N>S		No	ClinGen TOPMed gnomAD
CA396085761 CA396085763 rs1306317986	646	M>I		No	ClinGen TOPMed gnomAD
TCGA novel	646	M>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1316299714 CA396085768	646	M>V		No	ClinGen gnomAD
rs150826364 CA8036064	647	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	647	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	650	M>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	651	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8036062 rs141549260	652	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA396085704 rs1259771395	655	V>M		No	ClinGen TOPMed
rs149710303 CA8036060	656	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8036058 rs775705546	663	G>V		No	ClinGen ExAC gnomAD
rs746348166 CA8036056	665	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs779597367 CA8036055	669	T>I		No	ClinGen ExAC TOPMed gnomAD
CA396085593 rs1175796484	670	F>L		No	ClinGen TOPMed gnomAD
rs1423484253 CA396085589	671	L>I		No	ClinGen TOPMed
CA720978412 rs1466621953	672	F>T		No	ClinGen TOPMed

No associated diseases with Q8NEM2

6 regional properties for Q8NEM2

Type	Name	Position	InterPro Accession
repeat	Parallel beta-helix repeat	428 - 451	IPR006626-1
repeat	Parallel beta-helix repeat	452 - 473	IPR006626-2
repeat	Parallel beta-helix repeat	474 - 496	IPR006626-3
repeat	Parallel beta-helix repeat	497 - 518	IPR006626-4
repeat	Parallel beta-helix repeat	526 - 548	IPR006626-5
domain	Right handed beta helix domain	422 - 546	IPR039448

Functions

		Description
EC Number
Subcellular Localization	Midbody Cytoplasm, cytoskeleton, spindle	Displays weak localization to the spindle midzone in some early telophase cells and is concentrated at the midbody in late cytokinesis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
midbody	A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
spindle	The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

1 GO annotations of molecular function

Name	Definition
SH2 domain binding	Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.

2 GO annotations of biological process

Name	Definition
fibroblast growth factor receptor signaling pathway	The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
regulation of neural precursor cell proliferation	Any process that modulates the frequency, rate or extent of neural precursor cell proliferation.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9BZQ2	SHCBP1L	Testicular spindle-associated protein SHCBP1L	Homo sapiens (Human)	PR
Q3TTP0	Shcbp1l	Testicular spindle-associated protein SHCBP1L	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MADGSLTGGG	LEAAAMAPER	MGWAVEQELA	SLEKGLFQDE	DSCSDCSYRD	KPGSSLQSFM
70	80	90	100	110	120
PEGKTFFPEI	FQTNQLLFYE	RFRAYQDYIL	ADCKASEVQE	FTAEFLEKVL	EPSGWRAVWH
130	140	150	160	170	180
TNVFKVLVEI	TDVDFAALKA	VVRLAEPYLC	DSQVSTFTME	CMKELLDLKE	HRLPLQELWV
190	200	210	220	230	240
VFDDSGVFDQ	TALAIEHVRF	FYQNIWRSWD	EEEEDEYDYF	VRCVEPRLRL	HYDILEDRVP
250	260	270	280	290	300
SGLIVDYHNL	LSQCEESYRK	FLNLRSSLSN	CNSDSEQENI	SMVEGLKLYS	EMEQLKQKLK
310	320	330	340	350	360
LIENPLLRYV	FGYQKNSNIQ	AKGVRSSGQK	ITHVVSSTMM	AGLLRSLLTD	RLCQEPGEEE
370	380	390	400	410	420
REIQFHSDPL	SAINACFEGD	TVIVCPGHYV	VHGTFSIADS	IELEGYGLPD	DIVIEKRGKG
430	440	450	460	470	480
DTFVDCTGAD	IKISGIKFVQ	HDAVEGILIV	HRGKTTLENC	VLQCETTGVT	VRTSAEFLMK
490	500	510	520	530	540
NSDLYGAKGA	GIEIYPGSQC	TLSDNGIHHC	KEGILIKDFL	DEHYDIPKIS	MVNNIIHNNE
550	560	570	580	590	600
GYGVVLVKPT	IFSDLQENAE	DGTEENKALK	IQTSGEPDVA	ERVDLEELIE	CATGKMELCA
610	620	630	640	650	660
RTDPSEQVEG	NCEIVNELIA	ASTQKGQIKK	KRLSELGITQ	ADDNLMSQEM	FVGIVGNQFK
670
WNGKGSFGTF	LF