AiPD: Autoinhibited Protein Database

Gene name	Shcbp1l
Protein name	Testicular spindle-associated protein SHCBP1L
Names	SHC SH2 domain-binding protein 1-like protein
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:71836
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-88 (Predicted disordered autoinhibitory region) PR

1-88 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3TTP0-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388505486	9	E>K	No	EVA
rs233293521	11	K>E	No	EVA
rs3388506885	18	S>R	No	EVA
rs250980616	40	F>L	No	EVA
rs3388507996	47	V>I	No	EVA
rs3388507979	67	P>A	No	EVA
rs262076893	106	S>R	No	EVA
rs252365187	139	A>P	No	EVA
rs3388508035	147	W>R	No	EVA
rs3388507546	164	P>H	No	EVA
rs864292646	194	F>I	No	EVA
rs3390779511	212	E>A	No	EVA
rs3390760383	214	E>*	No	EVA
rs3390835656	214	E>D	No	EVA
rs3390806874	215	Y>S	No	EVA
rs3388507984	262	Y>F	No	EVA
rs3388503894	329	I>M	No	EVA
rs3388508808	366	K>E	No	EVA
rs262513627	394	N>D	No	EVA
rs3388504213	422	A>P	No	EVA
rs3390779499	443	S>K	No	EVA
rs3388503172	468	Q>*	No	EVA
rs3388503128	510	E>*	No	EVA
rs3390802715	514	A>S	No	EVA
rs3388503812	595	L>H	No	EVA
rs3388504238	602	G>A	No	EVA
rs3388508462	604	K>E	No	EVA
rs3388505444	612	K>I	No	EVA

Type	Name	Position	InterPro Accession
repeat	Parallel beta-helix repeat	479 - 500	IPR006626-1
repeat	Parallel beta-helix repeat	501 - 523	IPR006626-2
repeat	Parallel beta-helix repeat	524 - 557	IPR006626-3
repeat	Parallel beta-helix repeat	560 - 582	IPR006626-4
domain	Carbohydrate-binding/sugar hydrolysis domain	362 - 522	IPR006633
domain	Right handed beta helix domain	472 - 582	IPR039448

		Description
EC Number
Subcellular Localization	Cytoplasm, cytoskeleton, spindle	Colocalizes with alpha tubulin during meiosis (PubMed:24557841) Colocalizes with HSPA2 at spindle during the meiosis process (PubMed:24557841)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
meiotic spindle	A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle.

Name	Definition
No GO annotations for molecular function

Name	Definition
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
male meiosis cytokinesis	A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells.
positive regulation of chromosome organization	Any process that activates or increases the frequency, rate or extent of chromosome organization.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9BZQ2	SHCBP1L	Testicular spindle-associated protein SHCBP1L	Homo sapiens (Human)	PR
Q8NEM2	SHCBP1	SHC SH2 domain-binding protein 1	Homo sapiens (Human)	PR