AiPD: Autoinhibited Protein Database

Q8N9R8

Gene name	SCAI (C9orf126)
Protein name	Protein SCAI
Names	Suppressor of cancer cell invasion protein
Species	Homo sapiens (Human)
KEGG Pathway	hsa:286205
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-83 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-83 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8N9R8

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8N9R8-F1	Predicted				AlphaFoldDB

315 variants for Q8N9R8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA375149176 rs1271361062	2	V>A		No	ClinGen gnomAD
rs1308847223 CA375149178	2	V>I		No	ClinGen gnomAD
rs1187580533 CA375149171	3	R>K		No	ClinGen gnomAD
rs1228036967 CA375149148	5	A>T		No	ClinGen gnomAD
CA375149128 rs1270485551	6	R>P		No	ClinGen TOPMed
CA375149129 rs1270485551	6	R>Q		No	ClinGen TOPMed
CA375149109 rs1306341625	8	P>S		No	ClinGen gnomAD
CA199974944 rs888019024	9	Q>R		No	ClinGen Ensembl
CA375149067 rs1367045700	12	R>W		No	ClinGen TOPMed gnomAD
rs1298796203 CA375149040	14	R>P		No	ClinGen gnomAD
CA5238786 rs758268366	16	A>V		No	ClinGen ExAC
CA5238771 rs771180910	19	L>P		No	ClinGen ExAC TOPMed gnomAD
rs771180910 CA5238772	19	L>Q		No	ClinGen ExAC TOPMed gnomAD
rs1159211400 CA375148912	20	T>I		No	ClinGen gnomAD
CA5238770 rs747044631	22	T>P		No	ClinGen ExAC gnomAD
CA375148887 rs1405358715	23	V>M		No	ClinGen gnomAD
CA375148863 rs1409119056	24	E>A		No	ClinGen TOPMed gnomAD
rs1411918741 CA375148868	24	E>K		No	ClinGen TOPMed
rs1588262141 CA375148844	25	K>N		No	ClinGen Ensembl
CA5238769 rs764533096	25	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1564139828 CA375148820	27	P>S		No	ClinGen Ensembl
rs778701838 CA5238766	30	R>Q		No	ClinGen ExAC TOPMed
rs1260077346 CA375148746	33	R>G		No	ClinGen gnomAD
rs754728252 CA5238765	33	R>T		No	ClinGen ExAC gnomAD
CA375147674 rs589292	37	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs589292 COSM3763635 CA5238718 VAR_023236	37	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1376018490 CA375147671	37	A>V		No	ClinGen gnomAD
rs1198202957 CA375147670	38	L>V		No	ClinGen gnomAD
rs1438612429 CA375147663	39	K>E		No	ClinGen TOPMed gnomAD
CA375147653 rs1172954557	40	E>G		No	ClinGen TOPMed
CA375147647 rs1252854388	41	I>V		No	ClinGen gnomAD
CA375147629 rs368234163	43	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA5238717 rs368234163	43	S>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA199965063 rs778430484	45	G>R		No	ClinGen Ensembl
rs1234959450 CA375147600	48	E>G		No	ClinGen gnomAD
rs938947028 CA199965062	49	D>G		No	ClinGen Ensembl
CA5238715 rs370824389	50	D>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs780312589 CA5238713	58	T>I		No	ClinGen ExAC gnomAD
CA375147520 rs1588182930	60	T>A		No	ClinGen Ensembl
CA375147498 rs1407578223	63	C>R		No	ClinGen gnomAD
rs1299320910 CA375147488	64	Y>C		No	ClinGen gnomAD
COSM77398 rs983093168 CA199965060	68	K>I	ovary Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA5238708 rs373100131	74	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs767683920 CA374906962	81	Q>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	83	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	87	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200106227 CA199764930	92	G>*		No	ClinGen Ensembl
rs1204214481 CA374906872	94	T>P		No	ClinGen gnomAD
TCGA novel	102	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	103	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374906800 rs1377500229	103	K>N		No	ClinGen gnomAD
rs757124100 CA5238672	110	Q>H		No	ClinGen ExAC gnomAD
rs1229068126 CA374906722	113	D>N		No	ClinGen TOPMed
CA5238671 rs763999121	115	R>L		No	ClinGen ExAC TOPMed gnomAD
CA5238670 rs763999121	115	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1022821902 CA199764109	115	R>W		No	ClinGen TOPMed gnomAD
rs1239022893 CA374906701	116	Y>C		No	ClinGen TOPMed
CA5238669 rs72765247	118	L>F		No	ClinGen ExAC gnomAD
rs767809565 CA5238667	119	K>*		No	ClinGen ExAC gnomAD
rs767809565 CA5238668	119	K>E		No	ClinGen ExAC gnomAD
rs759859828 CA5238666	120	R>S		No	ClinGen ExAC
TCGA novel	122	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751914664 CA374906653	123	I>K		No	ClinGen ExAC gnomAD
CA5238665 rs751914664	123	I>T		No	ClinGen ExAC gnomAD
CA374906633 rs763293432	126	I>N		No	ClinGen ExAC gnomAD
rs763293432 CA5238663	126	I>T		No	ClinGen ExAC gnomAD
rs1564384631 CA374906617	129	K>E		No	ClinGen Ensembl
rs1564384631 CA374906618	129	K>Q		No	ClinGen Ensembl
CA374906590 rs1349448227	132	Q>H		No	ClinGen gnomAD
rs902467823 CA199764048	133	L>P		No	ClinGen Ensembl
TCGA novel	134	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	137	Y>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374906524 rs1161510823	140	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1359615510 CA374906523 COSM203402	140	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1182517544 CA374906499	144	T>A		No	ClinGen gnomAD
rs774919233 CA5238641	146	Y>C		No	ClinGen ExAC gnomAD
rs1338039787 CA374906475	147	L>P		No	ClinGen TOPMed
CA5238640 rs771569827	149	E>G		No	ClinGen ExAC gnomAD
CA5238639 rs759108347	157	I>V		No	ClinGen ExAC gnomAD
TCGA novel	159	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5238637 rs770613037	159	Q>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	160	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	160	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774466360 CA199762999	161	S>L		No	ClinGen Ensembl
rs777452314 CA5238635	163	Y>D		No	ClinGen ExAC gnomAD
rs1230495778 CA374906359	164	S>F		No	ClinGen gnomAD
rs1348789132 CA374906352	165	Q>H		No	ClinGen gnomAD
rs200434203 CA5238634	166	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1379621049 CA374906344	167	N>D		No	ClinGen gnomAD
CA374906294 rs1320651590	172	P>T		No	ClinGen gnomAD
CA374906288 rs1436715656	173	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA199758613 rs932023288	180	R>*		No	ClinGen TOPMed
CA5238619 rs762527108	186	I>V		No	ClinGen ExAC gnomAD
TCGA novel	189	C>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs769471221 CA5238617	193	N>K		No	ClinGen ExAC TOPMed gnomAD
rs748013964 CA5238616	194	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1249255735 CA374906127	196	D>A		No	ClinGen TOPMed gnomAD
CA374906130 rs1423760195	196	D>N		No	ClinGen gnomAD
rs768752095 CA5238614	199	K>N		No	ClinGen ExAC gnomAD
rs747043209 CA5238613	200	D>N		No	ClinGen ExAC TOPMed gnomAD
rs758584382 CA5238611	202	V>I		No	ClinGen ExAC TOPMed gnomAD
CA5238591 rs201987641	207	D>E		No	ClinGen ExAC TOPMed gnomAD
CA374906014 rs1355532452	211	D>H		No	ClinGen TOPMed
rs1442444036 CA374906010	211	D>V		No	ClinGen TOPMed
CA5238590 rs771219131	213	T>S		No	ClinGen ExAC TOPMed gnomAD
CA374905991 rs1428382345	214	H>R		No	ClinGen gnomAD
CA199757463 rs969196482	215	R>G		No	ClinGen Ensembl
rs749607765 CA5238589	215	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5238588 rs778125492	216	F>Y		No	ClinGen ExAC gnomAD
rs756546449 CA5238587	217	N>H		No	ClinGen ExAC gnomAD
rs1375964762 CA374905958	219	E>A		No	ClinGen gnomAD
CA374905947 rs1386124693	221	Q>K		No	ClinGen gnomAD
CA5238585 rs375187343	225	N>T		No	ClinGen ESP ExAC gnomAD
COSM1459985 CA199757445 rs992069877	231	V>A	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA5238582 rs764755427	232	A>E		No	ClinGen ExAC gnomAD
rs764755427 CA374905797	232	A>V		No	ClinGen ExAC gnomAD
CA5238581 rs761577070	235	I>T		No	ClinGen ExAC TOPMed gnomAD
rs373639867 COSM1459984 CA5238564	237	A>V	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1292085794 CA374905684	238	D>H		No	ClinGen gnomAD
CA374905661 rs1339156609	240	V>I		No	ClinGen gnomAD
CA199757282 rs998378790	242	V>L		No	ClinGen TOPMed
rs1176788129 CA374905623	243	L>I		No	ClinGen TOPMed
CA5238561 rs201358665	244	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1157276714 CA374905587	245	D>G		No	ClinGen gnomAD
rs1407016202 CA374905556	247	N>S		No	ClinGen gnomAD
TCGA novel	250	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374905522 rs1412270769	250	V>I		No	ClinGen TOPMed
rs1163553969 CA374905510	251	I>L		No	ClinGen gnomAD
CA374905503 rs1473742024	251	I>T		No	ClinGen gnomAD
rs1333350235 COSM1105134 CA374905477	253	S>L	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
rs1276044967 CA374905404	259	T>A		No	ClinGen TOPMed
rs1464990663 CA374905375	261	A>S		No	ClinGen gnomAD
rs1464990663 CA374905378	261	A>T		No	ClinGen gnomAD
rs759532689 CA5238557	262	P>S		No	ClinGen ExAC gnomAD
TCGA novel	266	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374905288 rs1206464363	267	G>D		No	ClinGen gnomAD
CA374905295 rs1339639898	267	G>S		No	ClinGen TOPMed
TCGA novel	269	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs774230577 CA5238556	269	I>T		No	ClinGen ExAC TOPMed gnomAD
CA5238555 rs770995108	274	S>P		No	ClinGen ExAC gnomAD
CA374905214 rs200657393	277	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs369558159 CA5238552 COSM1105132	278	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA374905207 rs1588155483	279	L>V		No	ClinGen Ensembl
CA5238550 rs777075487	280	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1327541072 CA374905183	283	N>H		No	ClinGen gnomAD
rs1350623294 CA374905172	284	C>F		No	ClinGen gnomAD
rs747552796 CA5238548	286	N>K		No	ClinGen ExAC gnomAD
rs1490631593 CA374905156	286	N>S		No	ClinGen TOPMed
CA5238518 rs755657455	288	V>G		No	ClinGen ExAC
rs1192589236 CA374904010	288	V>I		No	ClinGen gnomAD
rs1032716855 CA199746194	291	S>G		No	ClinGen gnomAD
CA5238517 rs747834302	293	L>I		No	ClinGen ExAC TOPMed gnomAD
rs1250195431 CA374903813	303	A>V		No	ClinGen gnomAD
COSM1132595 rs766263609 CA5238513	307	E>Q	Variant assessed as Somatic; 0.0 impact. prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA5238511 rs750443849	309	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA5238512 rs758352624	309	M>V		No	ClinGen ExAC TOPMed gnomAD
CA199746172 rs201670400	310	N>S		No	ClinGen 1000Genomes
rs765303079 CA5238510	312	A>V		No	ClinGen ExAC gnomAD
CA5238509 rs200286023	313	S>F		No	ClinGen 1000Genomes ExAC gnomAD
rs1162012527 CA374903737	315	M>K		No	ClinGen Ensembl
rs764269336 CA5238507	316	N>K		No	ClinGen ExAC gnomAD
CA5238508 rs776895636	316	N>S		No	ClinGen ExAC gnomAD
rs761064940 CA5238506	317	K>N		No	ClinGen ExAC gnomAD
rs1177518662 CA374903715	318	P>Q		No	ClinGen gnomAD
CA374903717 rs1359267491	318	P>T		No	ClinGen gnomAD
CA5238504 rs772652764	320	M>V		No	ClinGen ExAC gnomAD
CA374903694 rs1195879424	321	Q>R		No	ClinGen gnomAD
CA374903652 rs1317122603	325	D>E		No	ClinGen gnomAD
CA199745980 rs534187519	325	D>G		No	ClinGen 1000Genomes
CA374903650 rs1243658739	326	K>E		No	ClinGen gnomAD
rs1297646190 CA374903638	327	P>R		No	ClinGen gnomAD
rs1381439066 CA374903641	327	P>S		No	ClinGen gnomAD
rs371292629 CA199745976	328	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA199745971 rs958910406	328	T>N		No	ClinGen TOPMed gnomAD
rs371292629 CA5238481	328	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1287911753 CA374903626	330	R>*		No	ClinGen gnomAD
CA5238480 rs768297116	331	E>D		No	ClinGen ExAC TOPMed gnomAD
rs746668189 CA5238479	332	N>K		No	ClinGen ExAC gnomAD
rs771837312 CA5238477	333	P>L		No	ClinGen ExAC gnomAD
CA5238478 rs376710995	333	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1187982474 CA374903587	336	Y>H		No	ClinGen TOPMed
CA374903536 rs1343876072	343	F>C		No	ClinGen gnomAD
TCGA novel	344	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374903501 rs1210624213	348	T>I		No	ClinGen gnomAD
CA5238472 rs777724017	351	A>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	351	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5238470 rs752954982	352	A>V		No	ClinGen ExAC gnomAD
rs922025260 CA199745116	358	P>A		No	ClinGen Ensembl
COSM1105131 CA374903186 rs1203143896	360	N>S	liver endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed
rs774158530 CA199745105	365	I>F		No	ClinGen Ensembl
rs867788647 CA199745058	370	T>A		No	ClinGen TOPMed gnomAD
CA5238447 rs766656956	370	T>N		No	ClinGen ExAC
rs867788647 CA374903042	370	T>S		No	ClinGen TOPMed gnomAD
CA199745015 rs912133819	373	F>S		No	ClinGen Ensembl
rs750877373 CA5238445	374	P>R		No	ClinGen ExAC gnomAD
CA374902965 rs1351448507	375	T>A		No	ClinGen gnomAD
rs1369864954 CA374902947	376	G>R		No	ClinGen TOPMed
CA199744999 rs923431724	376	G>V		No	ClinGen TOPMed gnomAD
COSM3432856 rs760144612 CA5238443	377	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs775009298 CA5238442	377	R>H		No	ClinGen ExAC TOPMed gnomAD
CA5238441 rs767102086	379	D>G		No	ClinGen ExAC TOPMed gnomAD
CA374902902 rs1427535546	380	S>G		No	ClinGen gnomAD
CA374901490 rs1203819707	384	Y>F		No	ClinGen gnomAD
CA5238418 rs759147578	389	V>I		No	ClinGen ExAC TOPMed gnomAD
CA199743821 rs868625752	391	T>N		No	ClinGen Ensembl
CA374901344 rs1248779333	392	N>D		No	ClinGen gnomAD
rs766095075 CA5238416	395	R>W		No	ClinGen ExAC gnomAD
rs773164593 CA5238414	396	D>E		No	ClinGen ExAC gnomAD
CA374901177 rs1316489013	397	I>V		No	ClinGen gnomAD
CA199743803 rs375628930	402	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs375628930 CA5238413	402	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	404	H>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780636989 CA5238410	404	H>Q		No	ClinGen ExAC gnomAD
rs776776226 CA5238411	404	H>Y		No	ClinGen ExAC gnomAD
rs747158707 CA374900856	406	R>L		No	ClinGen ExAC gnomAD
CA5238409 rs747158707	406	R>Q		No	ClinGen ExAC gnomAD
CA374900840 rs1182383146	407	N>S		No	ClinGen gnomAD
CA374900821 rs1342875555	408	Q>P		No	ClinGen TOPMed
CA374900777 rs1475450869 COSM1105129	410	H>P	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs780104670 CA5238408	411	K>E		No	ClinGen ExAC gnomAD
TCGA novel	411	K>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778213347 CA5238385	419	G>R		No	ClinGen ExAC TOPMed gnomAD
CA374899579 rs1343382491	422	Y>C		No	ClinGen gnomAD
rs1263235175 CA374899589	422	Y>N		No	ClinGen TOPMed
CA374899561 rs1463436306	423	P>T		No	ClinGen TOPMed
rs1588139304 CA374899535	425	T>P		No	ClinGen Ensembl
CA374899529 rs1302525944	426	R>G		No	ClinGen gnomAD
CA199740234 rs1039187435	431	I>V		No	ClinGen Ensembl
rs1408848612 CA374899407	432	I>V		No	ClinGen gnomAD
COSM263515 rs757912013 CA5238381	435	S>L	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA5238378 rs757083632	439	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1231268835 CA374899243	440	A>P		No	ClinGen TOPMed gnomAD
CA374899241 rs1231268835	440	A>S		No	ClinGen TOPMed gnomAD
rs1203988885 CA374899234	440	A>V		No	ClinGen gnomAD
CA374893695 rs1465303498	445	T>I		No	ClinGen TOPMed
CA374893694 rs1408545551	446	N>D		No	ClinGen TOPMed
rs1318469422 CA374893575	451	P>L		No	ClinGen gnomAD
CA199729039 rs1034656402	453	V>A		No	ClinGen TOPMed
CA5238357 rs753626978	459	T>A		No	ClinGen ExAC gnomAD
rs763948902 CA374893453	459	T>I		No	ClinGen ExAC TOPMed gnomAD
rs763948902 CA5238356	459	T>R		No	ClinGen ExAC TOPMed gnomAD
rs755923769 CA5238355	464	A>S		No	ClinGen ExAC TOPMed gnomAD
CA199729025 rs755923769	464	A>T		No	ClinGen ExAC TOPMed gnomAD
CA374892474 rs1233170829	467	D>E		No	ClinGen gnomAD
CA374892377 rs1336927254	469	S>C		No	ClinGen gnomAD
CA5238326 rs766445170	471	R>*		No	ClinGen ExAC gnomAD
rs369515394 CA5238325	471	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA199726900 rs927131529	474	L>I		No	ClinGen TOPMed
rs765417164 CA5238323	477	L>F		No	ClinGen ExAC TOPMed gnomAD
rs765417164 CA199726889	477	L>V		No	ClinGen ExAC TOPMed gnomAD
COSM1330737 CA5238322 rs762197125	481	N>S	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs1173915798 CA374891897	485	A>V		No	ClinGen gnomAD
rs1416812745 CA374891609	494	S>T		No	ClinGen gnomAD
CA374891577 rs1216294741	495	M>I		No	ClinGen gnomAD
rs761266346 CA5238319	496	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA5238318 rs371655620	496	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	498	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA199726836 rs896091784	503	C>S		No	ClinGen Ensembl
rs747920037 CA5238313	505	E>A		No	ClinGen ExAC gnomAD
rs1281831362 CA374891217	506	Y>C		No	ClinGen gnomAD
CA5238312 rs780971540	507	L>F		No	ClinGen ExAC gnomAD
COSM1314442 CA199726808 rs1037274982	508	R>Q	Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1277388896 CA374891134	509	K>N		No	ClinGen gnomAD
rs1454797965 CA374891100	510	I>M		No	ClinGen gnomAD
CA5238311 rs754836411	511	N>D		No	ClinGen ExAC gnomAD
CA5238310 rs751483718	511	N>S		No	ClinGen ExAC gnomAD
rs940376510 CA199726801	512	R>C		No	ClinGen gnomAD
rs200076178 CA5238309	512	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA199726764 rs778179352	519	T>I		No	ClinGen ExAC TOPMed gnomAD
CA5238307 rs778179352	519	T>S		No	ClinGen ExAC TOPMed gnomAD
rs1407676780 CA374890909	520	H>N		No	ClinGen TOPMed
rs921772007 CA199726763	522	R>C		No	ClinGen gnomAD
CA5238306 rs202109345	522	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs974587395 CA199726759	524	I>T		No	ClinGen gnomAD
rs1192029108 CA374902221	527	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA199776425 rs1016280095	531	F>L		No	ClinGen Ensembl
CA374902033 rs1225344566	534	D>G		No	ClinGen gnomAD
rs530897438 CA5238287	538	R>C		No	ClinGen 1000Genomes ExAC gnomAD
CA5238286 rs754093354	539	L>V		No	ClinGen ExAC gnomAD
CA374901886 rs1588124319	540	L>F		No	ClinGen Ensembl
rs756508043 CA5238284	545	I>V		No	ClinGen ExAC TOPMed gnomAD
rs886114774 CA199776388	548	S>*		No	ClinGen Ensembl
CA5238282 rs768015078	549	A>V		No	ClinGen ExAC TOPMed gnomAD
CA374901584 rs1255629702	551	M>I		No	ClinGen TOPMed
rs774993223 CA5238280	552	R>K		No	ClinGen ExAC gnomAD
rs1322242274 CA374901494	555	K>E		No	ClinGen gnomAD
rs1410031763 CA374901447	557	F>I		No	ClinGen gnomAD
COSM40986 rs761432942 CA5238278	558	R>Q	large_intestine central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs764643339 CA5238279	558	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs755431697 CA5238260	564	P>S		No	ClinGen ExAC gnomAD
rs1315136079 CA374896742	565	E>D		No	ClinGen TOPMed
CA374896566 rs1305443035	574	E>*		No	ClinGen Ensembl
CA5238255 rs200979758	580	H>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1265219373 CA374896426	580	H>R		No	ClinGen gnomAD
CA374896404 rs1374853222	581	L>R		No	ClinGen Ensembl
CA374896391 rs1212055948	582	Q>R		No	ClinGen gnomAD
CA5238254 rs760324613	583	K>N		No	ClinGen ExAC gnomAD
CA5238253 rs775189186	584	H>Y		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	586	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	590	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA374896117 rs1248749612	593	D>G		No	ClinGen TOPMed
rs1374879277 CA374896092	594	V>I		No	ClinGen gnomAD
rs745717368 CA5238251	595	R>*		No	ClinGen ExAC gnomAD
CA5238250 rs541516222	595	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5238248 rs370360450	597	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	598	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA199763185 rs971549758	599	F>V		No	ClinGen gnomAD
rs1244969741 CA374895949	601	N>D		No	ClinGen TOPMed
CA5238245 rs770069119	603	I>T		No	ClinGen ExAC TOPMed gnomAD
rs778009281 CA5238246	603	I>V		No	ClinGen ExAC TOPMed gnomAD
CA374895882 rs1178171123	604	D>H		No	ClinGen TOPMed gnomAD
TCGA novel	604	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA199763174 rs754355465	605	D>A		No	ClinGen Ensembl
rs1445311517 CA374895824	605	D>E		No	ClinGen TOPMed gnomAD
CA199763171 rs958990744	606	Y>C		No	ClinGen TOPMed gnomAD

No associated diseases with Q8N9R8

No regional properties for Q8N9R8

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q8N9R8

Functions

		Description
EC Number
Subcellular Localization	Membrane ; Single-pass membrane protein Nucleus Cytoplasm	Nuclear localization is required for inhibition of MRTFA
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name	Definition
transcription corepressor activity	A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

2 GO annotations of biological process

Name	Definition
negative regulation of cell migration	Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
negative regulation of Rho protein signal transduction	Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8C8N2	Scai	Protein SCAI	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MVRGARQPQQ	PRSRLAPRLT	GTVEKPPRKR	RSRTEFALKE	IMSSGGAEDD	IPQGERKTVT
70	80	90	100	110	120
DFCYLLDKSK	QLFNGLRDLP	QYGQKQWQSY	FGRTFDVYTK	LWKFQQQHRQ	VLDNRYGLKR
130	140	150	160	170	180
WQIGEIASKI	GQLYYHYYLR	TSETSYLNEA	FSFYSAIRQR	SYYSQVNKED	RPELVVKKLR
190	200	210	220	230	240
YYARFIVVCL	LLNKMDVVKD	LVKELSDEIE	DYTHRFNTED	QVEWNLVLQE	VAAFIEADPV
250	260	270	280	290	300
MVLNDDNTIV	ITSNRLAETG	APLLEQGMIV	GQLSLADALI	IGNCNNQVKF	SELTVDMFRM
310	320	330	340	350	360
LQALEREPMN	LASQMNKPGM	QESADKPTRR	ENPHKYLLYK	PTFSQLYTFL	AASFKELPAN
370	380	390	400	410	420
SVLLIYLSAT	GVFPTGRSDS	EGPYDFGGVL	TNSNRDIING	DAIHKRNQSH	KEMHCLHPGD
430	440	450	460	470	480
LYPFTRKPLF	IIVDSSNSVA	YKNFTNLFGQ	PLVCLLSPTA	YPKALQDQSQ	RGSLFTLFLN
490	500	510	520	530	540
NPLMAFLFVS	GLSSMRRGLW	EKCQEYLRKI	NRDIAQLLTH	SRSIDQAFLQ	FFGDEFLRLL
550	560	570	580	590	600
LTRFIFCSAT	MRMHKIFRET	RNYPESYPQL	PRDETVENPH	LQKHILELAS	ILDVRNVFFE

NTIDDY