Q8C8N2
Gene name |
Scai |
Protein name |
Protein SCAI |
Names |
Suppressor of cancer cell invasion protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:320271 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8C8N2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8C8N2-F1 | Predicted | AlphaFoldDB |
15 variants for Q8C8N2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3391503087 | 68 | K>* | No | EVA | |
| rs3391472305 | 68 | K>I | No | EVA | |
| rs3412480553 | 184 | R>S | No | EVA | |
| rs3388549925 | 211 | D>V | No | EVA | |
| rs3388553850 | 249 | I>N | No | EVA | |
| rs3391351969 | 265 | E>Q | No | EVA | |
| rs3388554412 | 278 | A>V | No | EVA | |
| rs3388548360 | 288 | V>I | No | EVA | |
| rs3388548425 | 377 | R>H | No | EVA | |
| rs3388549963 | 465 | L>M | No | EVA | |
| rs3391530257 | 473 | S>G | No | EVA | |
| rs3391530138 | 483 | L>Q | No | EVA | |
| rs3388552085 | 489 | V>M | No | EVA | |
| rs3388549895 | 522 | R>H | No | EVA | |
| rs253859487 | 579 | P>L | No | EVA |
No associated diseases with Q8C8N2
No regional properties for Q8C8N2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8C8N2 | |||
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| transcription corepressor activity | A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of cell migration | Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration. |
| negative regulation of Rho protein signal transduction | Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8N9R8 | SCAI | Protein SCAI | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVRGARQSQQ | PRSRLAPRLS | GTVEKPPRKR | KSRTEFTLKE | TMSSGGAEDD | IPQGERKTVT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DFCYLLDKSK | QLFNGLRDLP | QYGQKQWQSY | FGRTFDVYTK | LWKFQQQHRQ | VLDNRYGLKR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WQIGEIASKI | GQLYYHYYLR | TSETSYLNEA | FSFYSAIRQR | SYYSQVNKED | RPELVVKKLR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YYARFIVVCL | LLNKMDVVKD | LVKELSDEIE | DYTHRFNTED | QVEWNLVLQE | VAAFIEADPV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MVLNDDNTIV | ITSNRLAETG | APLLEQGMIV | GQLSLADALI | IGNCNNQVKF | SELTVDMFRM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LQALEREPMN | LASQMNKPGI | QEPADKPTRR | ENPHKYLLYK | PTFSQLYTFL | AASFKELPAN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SVLLIYLSAT | GVFPTGRSDG | EGPYDFGGVL | TNSNRDIING | DAIHKRNQSH | KEMHCLHPGD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LYPFTRKPLF | IVVDSSNSVA | YKNFTNLFGQ | PLVCLLSPTA | YPKALQDQSQ | RGSLFTLFLN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NPLMAFLFVS | GLSSMRRGLW | EKCQEYLRKI | NRDIAQLLTH | SRSIDQAFLQ | FFGDEFLRLL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LTRFVFCSAT | MRMHKAFRET | RNYPESYPQL | PRDETVENPH | LQKHILELAS | ILDVRNIFFE |
| NSMDDY |