AiPD: Autoinhibited Protein Database

Q8N6I1

Gene name	EID2
Protein name	EP300-interacting inhibitor of differentiation 2
Names	EID-2, CREBBP/EP300 inhibitor 2, EID-1-like inhibitor of differentiation 2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:163126
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-158 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-158 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8N6I1

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8N6I1-F1	Predicted				AlphaFoldDB

200 variants for Q8N6I1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1476359575 CA405819515	2	S>P		No	ClinGen gnomAD
rs780962605 CA9433089	3	K>R		No	ClinGen ExAC gnomAD
rs376406346 CA9433088	5	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
VAR_038351 rs7252027 CA9433087	6	A>T		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs766205291 CA9433086	7	D>H		No	ClinGen ExAC gnomAD
rs1234918762 CA405819429	8	S>R		No	ClinGen gnomAD
rs368921747 CA9433084	9	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA405819414 rs1482362233	9	S>T		No	ClinGen TOPMed
CA308246166 rs878874622	11	P>L		No	ClinGen Ensembl
CA405819359 rs761190422	13	T>I		No	ClinGen ExAC TOPMed gnomAD
rs527811892 CA9433083	13	T>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9433082 rs761190422	13	T>R		No	ClinGen ExAC TOPMed gnomAD
CA405819340 rs1180304424	15	A>T		No	ClinGen TOPMed
rs776112037 CA9433081	15	A>V		No	ClinGen ExAC gnomAD
CA9433079 rs759958970	16	A>V		No	ClinGen ExAC gnomAD
rs1319076287 CA405819299	18	G>S		No	ClinGen gnomAD
rs774702560 CA9433078	19	D>N		No	ClinGen ExAC TOPMed gnomAD
CA405818284 rs1421197211	24	Q>*		No	ClinGen gnomAD
rs749543194 CA9433076	26	E>V		No	ClinGen ExAC TOPMed gnomAD
CA9433075 rs777815889	27	V>A		No	ClinGen ExAC gnomAD
rs1485225755 CA405818161	27	V>I		No	ClinGen gnomAD
rs983336566 CA308243099	28	G>D		No	ClinGen TOPMed gnomAD
rs769953956 CA405818127	29	R>C		No	ClinGen ExAC TOPMed gnomAD
CA9433074 rs769953956	29	R>S		No	ClinGen ExAC TOPMed gnomAD
CA9433072 rs781339867	30	G>R		No	ClinGen ExAC gnomAD
CA9433071 rs200885423	32	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs751479329 CA9433070	33	E>G		No	ClinGen ExAC TOPMed gnomAD
CA9433069 rs780008791	34	P>A		No	ClinGen ExAC gnomAD
CA405817926 rs1295459634	35	A>V		No	ClinGen gnomAD
CA9433067 rs750122220	37	A>V		No	ClinGen ExAC gnomAD
CA405817846 rs1447778803	38	Q>E		No	ClinGen gnomAD
rs1600774540 CA405817824	38	Q>H		No	ClinGen Ensembl
CA405817789 rs1293375471	40	E>K		No	ClinGen gnomAD
rs565043525 CA308243087	40	E>V		No	ClinGen 1000Genomes
CA9433066 rs764767748	41	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA405817740 rs1355931023	42	A>T		No	ClinGen gnomAD
rs77663137 CA405817686	43	G>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9433064 rs77663137	43	G>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs761442952 CA405817697 CA9433065	43	G>R		No	ClinGen ExAC gnomAD
rs1194944950 CA405817578	46	A>V		No	ClinGen TOPMed gnomAD
rs760044833 CA9433062	47	M>L		No	ClinGen ExAC gnomAD
rs1252229428 CA405817518	48	A>E		No	ClinGen gnomAD
CA9433061 rs766758554	49	A>E		No	ClinGen ExAC TOPMed gnomAD
CA405817514 rs1481466555	49	A>T		No	ClinGen gnomAD
CA9433060 rs766758554	49	A>V		No	ClinGen ExAC TOPMed gnomAD
CA308243071 rs544272604	50	A>S		No	ClinGen TOPMed gnomAD
CA405817502 rs544272604	50	A>T		No	ClinGen TOPMed gnomAD
CA9433059 rs763193902	50	A>V		No	ClinGen ExAC gnomAD
CA9433058 rs773534199	51	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1345335547 CA405817467	52	G>A		No	ClinGen TOPMed
rs1345335547 CA405817468	52	G>E		No	ClinGen TOPMed
TCGA novel	53	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs76427625 CA9433057	54	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9433056 rs76427625	54	P>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1485790378 CA405817434	55	V>L		No	ClinGen gnomAD
rs1372364956 CA405817402	57	A>T		No	ClinGen gnomAD
TCGA novel	57	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA405817382 rs572188094	58	A>P		No	ClinGen 1000Genomes gnomAD
rs572188094 CA308243065	58	A>T		No	ClinGen 1000Genomes gnomAD
VAR_050964 CA9433055 rs3746086	60	E>A		No	ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
TCGA novel	60	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA308243057 rs927575978	61	G>A		No	ClinGen TOPMed
rs1295711745 CA405817324	61	G>S		No	ClinGen TOPMed gnomAD
CA308243051 rs1011075161	63	M>I		No	ClinGen TOPMed gnomAD
CA405817298 rs1600774450	63	M>R		No	ClinGen Ensembl
CA405817290 rs1375930556	64	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs768798913 CA9433054	65	A>V	Variant assessed as Somatic; 0.0004941 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA9433053 rs746965679	66	A>D		No	ClinGen ExAC
rs1376900565 CA405817284	66	A>S		No	ClinGen gnomAD
CA405817271 rs1266503065	68	A>P		No	ClinGen TOPMed
CA308243041 rs1055692898	70	P>A		No	ClinGen Ensembl
rs1055692898 CA308243043	70	P>T		No	ClinGen Ensembl
rs1476997343 CA405817250	71	A>G		No	ClinGen TOPMed
rs1476997343 CA405817249	71	A>V		No	ClinGen TOPMed
rs927017052 CA308243036	72	A>V		No	ClinGen TOPMed
CA308243033 rs1045430519	75	R>K		No	ClinGen TOPMed
CA405817228 rs1045430519	75	R>M		No	ClinGen TOPMed
CA405817223 rs1315068909	76	G>R		No	ClinGen TOPMed gnomAD
rs1033087356 CA308243029	77	A>S		No	ClinGen TOPMed gnomAD
rs1033087356 CA405817219	77	A>T		No	ClinGen TOPMed gnomAD
CA9433049 rs745634901	77	A>V		No	ClinGen ExAC gnomAD
rs1251040653 CA405817203	80	A>T		No	ClinGen gnomAD
rs778692509 CA9433048	82	A>V		No	ClinGen ExAC TOPMed gnomAD
CA405817181 rs1255952065	83	A>V		No	ClinGen gnomAD
rs753431194 CA405817176	84	L>F		No	ClinGen ExAC TOPMed gnomAD
rs756864090 CA9433047	84	L>M		No	ClinGen ExAC gnomAD
CA405817172 rs1308243691	85	A>S		No	ClinGen gnomAD
CA405817168 rs1171232481	86	R>G		No	ClinGen gnomAD
CA9433045 rs763613260	87	A>S		No	ClinGen ExAC gnomAD
rs1430757505 CA405817157	87	A>V		No	ClinGen gnomAD
CA9433044 rs755577157	89	A>V		No	ClinGen ExAC TOPMed gnomAD
rs752098045 CA9433043	90	A>T		No	ClinGen ExAC gnomAD
rs1400923081 CA405817141	90	A>V		No	ClinGen TOPMed gnomAD
CA308243002 rs983369272	91	G>S		No	ClinGen Ensembl
CA405817104 rs1449702870	94	S>R		No	ClinGen TOPMed
rs766846649 CA9433038	96	A>G		No	ClinGen ExAC
CA9433036 rs763435288	97	A>V		No	ClinGen ExAC gnomAD
CA9433034 rs765574260	100	A>G		No	ClinGen ExAC TOPMed gnomAD
rs994490614 CA405816972	103	A>G		No	ClinGen TOPMed gnomAD
rs761958828 CA405816978	103	A>P		No	ClinGen ExAC gnomAD
rs761958828 CA9433028	103	A>S		No	ClinGen ExAC gnomAD
CA9433030 rs761958828	103	A>T		No	ClinGen ExAC gnomAD
rs994490614 CA308242980	103	A>V		No	ClinGen TOPMed gnomAD
CA405816917 COSM293630 rs1390440550	106	A>V	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA405816910 COSM1304564 rs1600774303	107	E>K	urinary_tract [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1228191294 CA405816877	108	V>F		No	ClinGen gnomAD
CA405816873 rs1600774297	108	V>G		No	ClinGen Ensembl
rs1228191294 CA405816883	108	V>I		No	ClinGen gnomAD
CA405816871 rs1327477029	109	A>T		No	ClinGen gnomAD
CA9433027 rs555882270	109	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA405816859 rs1233579558	110	R>C		No	ClinGen gnomAD
CA9433026 rs768889030	111	L>F		No	ClinGen ExAC gnomAD
CA405816836 rs920467211	112	L>V		No	ClinGen TOPMed
rs1331701171 CA405816817	114	E>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs748066706 CA9433025	115	P>A		No	ClinGen ExAC TOPMed gnomAD
CA405816786 rs1319747923	115	P>L		No	ClinGen gnomAD
rs748066706 CA405816790	115	P>S		No	ClinGen ExAC TOPMed gnomAD
rs771897313 CA9433024 CA405816767	116	V>L		No	ClinGen ExAC gnomAD
rs771897313 CA9433023	116	V>M		No	ClinGen ExAC gnomAD
CA9433022 rs745750021	117	D>G		No	ClinGen ExAC gnomAD
CA405816749 rs745750021	117	D>V		No	ClinGen ExAC gnomAD
CA9433019 rs200060326	120	G>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA405816631 rs200060326	120	G>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9433020 rs757024402	120	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1430333932 CA405816616	121	P>L		No	ClinGen gnomAD
CA405816580 rs1208698093	123	G>V		No	ClinGen gnomAD
CA405816564 rs1216134569	124	R>K		No	ClinGen TOPMed
CA405816542 rs1600774253	125	P>L		No	ClinGen Ensembl
rs1275196657 CA405816545	125	P>S		No	ClinGen TOPMed
rs1463919609 CA405816534	126	R>G		No	ClinGen gnomAD
rs1275508604 CA405816525	126	R>K		No	ClinGen gnomAD
CA9433017 rs755666985	128	R>G		No	ClinGen ExAC TOPMed gnomAD
rs752192167 CA9433016 COSM3712924	128	R>T	upper_aerodigestive_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA9433015 rs766980168	129	H>Y		No	ClinGen ExAC gnomAD
rs1186365761 CA405816472	130	G>R		No	ClinGen TOPMed
TCGA novel	132	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1568460280 CA405816400	132	G>A		No	ClinGen Ensembl
rs758836307 CA405816382	133	G>R		No	ClinGen ExAC TOPMed gnomAD
rs758836307 CA9433014	133	G>S		No	ClinGen ExAC TOPMed gnomAD
CA308242949 rs1011146910	134	L>V		No	ClinGen TOPMed gnomAD
TCGA novel	136	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1600774214 CA405816291	137	L>V		No	ClinGen Ensembl
CA9433012 rs765542168	138	P>S		No	ClinGen ExAC gnomAD
CA405816270 rs765542168	138	P>T		No	ClinGen ExAC gnomAD
rs1161640598 CA405816236	139	Y>C		No	ClinGen TOPMed gnomAD
CA9433011 rs780114375	139	Y>D		No	ClinGen ExAC TOPMed gnomAD
CA405816248 rs780114375	139	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA405816232 rs1161640598	139	Y>S		No	ClinGen TOPMed gnomAD
rs754154805 CA9433010	140	L>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs764391216 CA9433009	141	R>G		No	ClinGen ExAC gnomAD
CA9433008 rs760902160	143	R>C		No	ClinGen ExAC gnomAD
CA9433007 rs775714558	146	L>F		No	ClinGen ExAC
CA9433006 rs772132619	146	L>R		No	ClinGen ExAC gnomAD
rs1357075984 CA405815942	147	S>G		No	ClinGen gnomAD
CA9433005 rs759414406	147	S>R		No	ClinGen ExAC gnomAD
rs926061690 CA308242932	151	I>S		No	ClinGen TOPMed
rs770668659 CA9433003	152	N>S		No	ClinGen ExAC TOPMed gnomAD
CA9433001 rs567845080	158	R>H		No	ClinGen 1000Genomes ExAC gnomAD
CA405815618 rs1225538818	159	H>R		No	ClinGen gnomAD
CA405815586 rs1275322575	161	L>M		No	ClinGen gnomAD
CA9433000 rs769435100	165	P>R		No	ClinGen ExAC gnomAD
rs754498911 CA308242923	166	I>V		No	ClinGen TOPMed gnomAD
CA405815477 rs1411925188	168	P>S		No	ClinGen gnomAD
CA308242921 rs974860825	169	G>S		No	ClinGen TOPMed
rs750928494 CA9432996	172	Q>P		No	ClinGen ExAC gnomAD
CA405815401 rs1468059012	173	E>Q		No	ClinGen Ensembl
CA405815372 rs1173628483	174	L>P		No	ClinGen gnomAD
rs987273623 CA308242918	175	E>G		No	ClinGen TOPMed
rs1477969675 CA405815313	178	R>C		No	ClinGen gnomAD
rs1376404748 CA405815241	182	V>L		No	ClinGen Ensembl
rs1568460232 CA405815185	184	A>S		No	ClinGen Ensembl
rs754244593 CA9432993	188	R>G		No	ClinGen ExAC gnomAD
rs764483293 CA9432992	191	A>V		No	ClinGen ExAC gnomAD
CA405814985 rs1167215294	192	F>S		No	ClinGen TOPMed
CA405814944 rs1202437012	194	A>G		No	ClinGen TOPMed gnomAD
rs752911187 CA9432990	199	N>D		No	ClinGen ExAC gnomAD
CA405814694 rs1218629495	200	P>R		No	ClinGen gnomAD
CA9432989 rs566630361	201	H>Y		No	ClinGen 1000Genomes ExAC gnomAD
CA9432988 rs759628844	202	R>G		No	ClinGen ExAC TOPMed gnomAD
CA9432987 rs774203684	203	V>L		No	ClinGen ExAC gnomAD
CA308242898 rs372306245	204	D>N		No	ClinGen ESP TOPMed gnomAD
CA405814576 rs1348622870	205	L>F		No	ClinGen gnomAD
rs772998243 CA9432984	207	I>V		No	ClinGen ExAC gnomAD
rs1377397335 CA405814488	208	L>V		No	ClinGen TOPMed gnomAD
CA308242885 rs898824120	209	T>S		No	ClinGen TOPMed
rs1253727054 CA405814353	212	I>V		No	ClinGen TOPMed
CA9432981 rs747822250	215	T>A		No	ClinGen ExAC gnomAD
TCGA novel	216	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1352275422 CA405814255	216	A>S		No	ClinGen TOPMed
rs1160660599 CA405814236	217	S>A		No	ClinGen gnomAD
rs1267134832 CA405814234	217	S>C		No	ClinGen TOPMed
rs1473095060 CA405814206	218	E>G		No	ClinGen gnomAD
rs1001964458 CA308242874	222	P>S		No	ClinGen TOPMed
rs1179618859 CA405814069	223	L>V		No	ClinGen gnomAD
CA9432978 rs746509987	224	I>T		No	ClinGen ExAC TOPMed gnomAD
CA405813963 rs1270014203	226	E>K		No	ClinGen TOPMed
CA9432977 rs779348803	227	L>I		No	ClinGen ExAC TOPMed
rs1462453328 CA405813779	233	I>F		No	ClinGen gnomAD
rs778300745 CA9432972	236	E>D		No	ClinGen ExAC TOPMed gnomAD
CA405813719 rs1180488637	236	E>Q		No	ClinGen TOPMed gnomAD

No associated diseases with Q8N6I1

No regional properties for Q8N6I1

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q8N6I1

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name	Definition
SMAD binding	Binding to a SMAD signaling protein.
transcription corepressor activity	A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

9 GO annotations of biological process

Name	Definition
cell differentiation	The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
muscle organ development	The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
negative regulation of transforming growth factor beta receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
regulation of cell population proliferation	Any process that modulates the frequency, rate or extent of cell proliferation.
regulation of transforming growth factor beta receptor signaling pathway	Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway.
SMAD protein complex assembly	The aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins.
transforming growth factor beta receptor complex assembly	The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q17QW4	EID2	EP300-interacting inhibitor of differentiation 2	Bos taurus (Bovine)	PR
Q6X7S9	Eid2	EP300-interacting inhibitor of differentiation 2	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MSKLPADSSV	PQTGAANGDR	DVPQAEVGRG	RREPAPAQPE	EAGEGAMAAA	RGGPVPAARE
70	80	90	100	110	120
GRMAAARAAP	AAAARGAPVA	AAALARAAAA	GRESPAAAAA	REARMAEVAR	LLGEPVDEEG
130	140	150	160	170	180
PEGRPRSRHG	NGGLAALPYL	RLRHPLSVLG	INYQQFLRHY	LENYPIAPGR	IQELEERRRR
190	200	210	220	230
FVEACRAREA	AFDAEYQRNP	HRVDLDILTF	TIALTASEVI	NPLIEELGCD	KFINRE