Q8MIZ3

PR
Gene name
DCPS (DCS1, HINT5)
Protein name
m7GpppX diphosphatase
Names
DCS-1, Decapping scavenger enzyme, Hint-related 7meGMP-directed hydrolase, Histidine triad nucleotide-binding protein 5, Histidine triad protein member 5, HINT-5, Scavenger mRNA-decapping enzyme DcpS
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:396689
EC number
3.6.1.59: In phosphorus-containing anhydrides
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8MIZ3

Entry ID Method Resolution Chain Position Source
AF-Q8MIZ3-F1 Predicted AlphaFoldDB

8 variants for Q8MIZ3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs791778493 32 V>I No EVA
rs711427007 77 G>V No EVA
rs694258333 80 A>D No EVA
rs713832202 120 P>H No EVA
rs708063890 245 L>F No EVA
rs330031055 255 R>L No EVA
rs81216631 294 R>L No EVA
rs790058201 337 S>R No EVA

No associated diseases with Q8MIZ3

1 regional properties for Q8MIZ3

Type Name Position InterPro Accession
conserved_site Histidine triad, conserved site 264 - 282 IPR019808

Functions

Description
EC Number 3.6.1.59 In phosphorus-containing anhydrides
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Predominantly localized in the nucleus
  • Nucleocytoplasmic shuttling protein that can transiently enter the cytoplasm in mammalian cells in a XPO1/CRM1-dependent manner
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
P-body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.

3 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.
m7G(5')pppN diphosphatase activity Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide.
RNA 7-methylguanosine cap binding Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II.

4 GO annotations of biological process

Name Definition
cellular response to menadione Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position.
deadenylation-dependent decapping of nuclear-transcribed mRNA Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length.
mRNA cis splicing, via spliceosome The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript.
negative regulation of programmed cell death Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9DAR7 Dcps m7GpppX diphosphatase Mus musculus (Mouse) PR
10 20 30 40 50 60
MADTAPQPSK RKRERDPEEA EAPSTEEKEA RVGNGTSAPV RLPFSGFRVK KVLRESARDK
70 80 90 100 110 120
IIFLHGKVNE ASGDGDGEDA IVILEKTPFQ VDQVAQLLMG SPELQLQFSN DIYSTYHLFP
130 140 150 160 170 180
PRQLSDVKTT VVYPATEKHL QKYLHQDLHL VRETGGDYKN ITLPHLESQS LSIQWVYNIL
190 200 210 220 230 240
DKKAEADRIV FENPDPSDGF VLIPDLKWNQ KQLDDLYLIA ICHRRGIKSL RDLTPEHLPL
250 260 270 280 290 300
LRNILREGQE AILQRYQVTG DRLRVYLHYL PSYYHLHVHF TALGFEAPGA GVERAHLLAE
310 320 330
VIENLEQDPE HYQRRTLTFA LRADDPLLTL LQEAQRS