AiPD: Autoinhibited Protein Database

Gene name	ARPC2A (DIS2, At1g30825, T17H7.13)
Protein name	Actin-related protein 2/3 complex subunit 2A
Names	Actin-related protein C2A, Arp2/3 complex 34 kDa subunit, p34-ARC, Protein DISTORTED TRICHOMES 2
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT1G30825
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

175-251 (Predicted disordered autoinhibitory region) PR

175-251 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8LGI3-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
ENSVATH01132638	21	N>S	No	1000Genomes
ENSVATH04680112	42	V>I	No	1000Genomes
tmp_1_10961540_T_A	51	L>Q	No	1000Genomes
ENSVATH01132642	51	L>V	No	1000Genomes
ENSVATH14015537	53	L>F	No	1000Genomes
tmp_1_10961898_T_C	139	S>P	No	1000Genomes
ENSVATH04680115	141	T>R	No	1000Genomes
tmp_1_10961970_G_T	163	V>L	No	1000Genomes
ENSVATH14015542	204	T>I	No	1000Genomes
tmp_1_10962328_C_T	222	P>S	No	1000Genomes
ENSVATH14015544	230	A>T	No	1000Genomes
ENSVATH14015546	249	R>S	No	1000Genomes
ENSVATH12427730	258	H>Y	No	1000Genomes
ENSVATH04680126	272	M>L	No	1000Genomes
ENSVATH12427732	285	Q>L	No	1000Genomes
tmp_1_10962812_G_A	286	A>T	No	1000Genomes
tmp_1_10962859_C_G	301	N>K	No	1000Genomes
ENSVATH12427826	311	E>D	No	1000Genomes
ENSVATH04680128	314	H>L	No	1000Genomes
ENSVATH04680129	316	N>D	No	1000Genomes

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q8LGI3

		Description
EC Number
Subcellular Localization	Cytoplasm, cytoskeleton Cell projection
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
Arp2/3 protein complex	A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments.
cell projection	A prolongation or process extending from a cell, e.g. a flagellum or axon.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Name	Definition
actin filament binding	Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
structural constituent of cytoskeleton	The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.

Name	Definition
actin filament organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
actin filament polymerization	Assembly of actin filaments by the addition of actin monomers to a filament.
Arp2/3 complex-mediated actin nucleation	The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins.
regulation of actin filament polymerization	Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.
trichome morphogenesis	The process in which the structures of a hair cell (trichome) cell are generated and organized. This process occurs while the initially relatively unspecialized epidermal cell is acquiring the specialized features of a hair cell. An example of this process is found in Arabidopsis thaliana.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3MHR7	ARPC2	Actin-related protein 2/3 complex subunit 2	Bos taurus (Bovine)	PR