Q3MHR7
PR
Gene name |
ARPC2 |
Protein name |
Actin-related protein 2/3 complex subunit 2 |
Names |
Arp2/3 complex 34 kDa subunit, p34-ARC |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:540838 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
25 structures for Q3MHR7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1K8K | X-ray | 200 A | D | 1-300 | PDB |
| 1TYQ | X-ray | 255 A | D | 1-300 | PDB |
| 1U2V | X-ray | 255 A | D | 1-300 | PDB |
| 2P9I | X-ray | 246 A | D | 1-300 | PDB |
| 2P9K | X-ray | 259 A | D | 1-300 | PDB |
| 2P9L | X-ray | 265 A | D | 1-300 | PDB |
| 2P9N | X-ray | 285 A | D | 1-300 | PDB |
| 2P9P | X-ray | 290 A | D | 1-300 | PDB |
| 2P9S | X-ray | 268 A | D | 1-300 | PDB |
| 2P9U | X-ray | 275 A | D | 1-300 | PDB |
| 3DXK | X-ray | 270 A | D | 1-300 | PDB |
| 3DXM | X-ray | 285 A | D | 1-300 | PDB |
| 3RSE | X-ray | 265 A | D | 1-300 | PDB |
| 3UKR | X-ray | 248 A | D | 1-300 | PDB |
| 3UKU | X-ray | 275 A | D | 1-300 | PDB |
| 3ULE | X-ray | 250 A | D | 1-300 | PDB |
| 4JD2 | X-ray | 308 A | D | 1-300 | PDB |
| 4XEI | X-ray | 387 A | D | 1-300 | PDB |
| 4XF2 | X-ray | 500 A | D/W | 1-300 | PDB |
| 6DEC | X-ray | 460 A | D/K | 1-300 | PDB |
| 7JPN | EM | 324 A | D | 1-300 | PDB |
| 7T5Q | EM | 340 A | D | 1-300 | PDB |
| 7TPT | EM | 390 A | D | 1-300 | PDB |
| 8TAH | EM | 289 A | D | 1-300 | PDB |
| AF-Q3MHR7-F1 | Predicted | AlphaFoldDB |
37 variants for Q3MHR7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs466584163 | 2 | I>F | No | EVA | |
| rs480195197 | 2 | I>S | No | EVA | |
| rs449227283 | 3 | L>P | No | EVA | |
| rs437836776 | 5 | E>Q | No | EVA | |
| rs433294471 | 6 | V>G | No | EVA | |
| rs465079995 | 6 | V>L | No | EVA | |
| rs473241274 | 7 | N>K | No | EVA | |
| rs441947321 | 13 | E>A | No | EVA | |
| rs455923614 | 16 | A>P | No | EVA | |
| rs444644657 | 18 | K>Q | No | EVA | |
| rs458367589 | 18 | K>T | No | EVA | |
| rs478415237 | 19 | F>C | No | EVA | |
| rs440120353 | 19 | F>L | No | EVA | |
| rs460209777 | 20 | E>A | No | EVA | |
| rs480256689 | 20 | E>D | No | EVA | |
| rs448889456 | 24 | A>S | No | EVA | |
| rs435375137 | 68 | Q>E | No | EVA | |
| rs455066996 | 72 | A>S | No | EVA | |
| rs464953529 | 93 | V>G | No | EVA | |
| rs446865719 | 94 | S>F | No | EVA | |
| rs466838345 | 98 | D>A | No | EVA | |
| rs476113878 | 116 | L>F | No | EVA | |
| rs438238288 | 117 | K>I | No | EVA | |
| rs451829824 | 138 | G>* | No | EVA | |
| rs471955633 | 145 | H>N | No | EVA | |
| rs441656900 | 149 | D>Y | No | EVA | |
| rs454783582 | 184 | E>D | No | EVA | |
| rs437031297 | 193 | H>R | No | EVA | |
| rs457154824 | 195 | A>P | No | EVA | |
| rs470749121 | 212 | T>A | No | EVA | |
| rs438959130 | 213 | D>E | No | EVA | |
| rs459011493 | 218 | D>A | No | EVA | |
| rs472636977 | 218 | D>E | No | EVA | |
| rs471431378 | 261 | Y>* | No | EVA | |
| rs383906690 | 271 | S>T | No | EVA | |
| rs460103566 | 286 | K>N | No | EVA | |
| rs465689055 | 298 | S>T | No | EVA |
No associated diseases with Q3MHR7
No regional properties for Q3MHR7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q3MHR7 | |||
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| anchoring junction | A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix. |
| Arp2/3 protein complex | A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| site of double-strand break | A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| structural constituent of cytoskeleton | The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| actin filament polymerization | Assembly of actin filaments by the addition of actin monomers to a filament. |
| Arp2/3 complex-mediated actin nucleation | The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins. |
| regulation of actin filament polymerization | Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8LGI3 | ARPC2A | Actin-related protein 2/3 complex subunit 2A | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MILLEVNNRI | IEETLALKFE | NAAAGNKPEA | VEVTFADFDG | VLYHISNPNG | DKTKVMVSIS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LKFYKELQAH | GADELLKRVY | GSYLVNPESG | YNVSLLYDLE | NLPASKDSIV | HQAGMLKRNC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FASVFEKYFQ | FQEEGKEGEN | RAVIHYRDDE | TMYVESKKDR | VTVVFSTVFK | DDDDVVIGKV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FMQEFKEGRR | ASHTAPQVLF | SHREPPLELK | DTDAAVGDNI | GYITFVLFPR | HTNASARDNT |
| 250 | 260 | 270 | 280 | 290 | |
| INLIHTFRDY | LHYHIKCSKA | YIHTRMRAKT | SDFLKVLNRA | RPDAEKKEMK | TITGKTFSSR |