Q8LCY2

PR
Gene name
At5g03905 (F8F6_110, MED24.21)
Protein name
Iron-sulfur assembly protein IscA-like 2, mitochondrial
Names
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G03905
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-96 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8LCY2

Entry ID Method Resolution Chain Position Source
AF-Q8LCY2-F1 Predicted AlphaFoldDB

8 variants for Q8LCY2

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH00605364 6 V>M No 1000Genomes
tmp_5_1052747_A_C 7 K>T No 1000Genomes
ENSVATH13911512 23 L>W No 1000Genomes
ENSVATH10549945 38 S>Y No 1000Genomes
tmp_5_1053401_G_C 68 E>D No 1000Genomes
ENSVATH13911570 89 K>M No 1000Genomes
tmp_5_1053489_C_G 98 P>A No 1000Genomes
tmp_5_1054027_A_C 155 M>L No 1000Genomes

No associated diseases with Q8LCY2

1 regional properties for Q8LCY2

Type Name Position InterPro Accession
domain FeS cluster biogenesis 51 - 151 IPR000361

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
2 iron, 2 sulfur cluster binding Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
iron ion binding Binding to an iron (Fe) ion.

2 GO annotations of biological process

Name Definition
iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
protein maturation by [4Fe-4S] cluster transfer The transfer of an assembled 4Fe-4S] cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q86U28 ISCA2 Iron-sulfur cluster assembly 2 homolog, mitochondrial Homo sapiens (Human) PR
Q8GW20 At5g03900 Uncharacterized protein At5g03900, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSRSLVKRVA PYLAGRIREN HRLLNFSSAS AIKEASSSSS SQPESSSNDV VHLSDNCIRR
70 80 90 100 110 120
MKELQSSEPE KKMLRLGVET GGCSGFQYKF ELDNRTNPDD RVFEKNGVKL VVDNVSYDLV
130 140 150
KGATIDYEEE LIRAAFVVAV NPSAVGGCSC KSSFMVKL