Q8LA32
Gene name |
LUL4 (RF208, At3g06140, F28L1.8) |
Protein name |
Probable E3 ubiquitin-protein ligase LUL4 |
Names |
Probable RING-type E3 ubiquitin transferase LUL4, Protein LOG2-LIKE UBIQUITIN LIGASE 4, RING finger protein 208 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT3G06140 |
EC number |
2.3.2.27: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8LA32
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8LA32-F1 | Predicted | AlphaFoldDB |
35 variants for Q8LA32
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_1858720_G_A | 20 | L>F | No | 1000Genomes | |
| tmp_3_1858688_A_T | 30 | Y>* | No | 1000Genomes | |
| ENSVATH05781265 | 30 | Y>H | No | 1000Genomes | |
| tmp_3_1858609_G_A | 57 | P>S | No | 1000Genomes | |
| tmp_3_1858564_A_T | 72 | Y>N | No | 1000Genomes | |
| ENSVATH05781263 | 82 | F>Y | No | 1000Genomes | |
| tmp_3_1858520_C_G | 86 | Q>H | No | 1000Genomes | |
| ENSVATH05781262 | 88 | N>S | No | 1000Genomes | |
| tmp_3_1858499_C_A | 93 | M>I | No | 1000Genomes | |
| tmp_3_1858453_G_A | 109 | P>S | No | 1000Genomes | |
| ENSVATH10519771 | 143 | H>P | No | 1000Genomes | |
| tmp_3_1857859_G_C | 162 | F>L | No | 1000Genomes | |
| tmp_3_1857857_A_C | 163 | F>C | No | 1000Genomes | |
| tmp_3_1857850_C_A | 165 | K>N | No | 1000Genomes | |
| ENSVATH05781252 | 168 | P>Q | No | 1000Genomes | |
| ENSVATH05781252 | 168 | P>R | No | 1000Genomes | |
| ENSVATH05781251 | 171 | T>A | No | 1000Genomes | |
| tmp_3_1857820_C_A | 175 | Q>H | No | 1000Genomes | |
| tmp_3_1857816_G_A | 177 | P>S | No | 1000Genomes | |
| tmp_3_1857792_A_G | 185 | F>L | No | 1000Genomes | |
| tmp_3_1857740_C_T | 202 | G>E | No | 1000Genomes | |
| tmp_3_1857692_T_C | 218 | E>G | No | 1000Genomes | |
| ENSVATH05781249 | 245 | K>N | No | 1000Genomes | |
| ENSVATH02117993 | 257 | D>E | No | 1000Genomes | |
| ENSVATH05781248 | 261 | K>E | No | 1000Genomes | |
| ENSVATH10519743 | 274 | V>A | No | 1000Genomes | |
| tmp_3_1857509_C_T | 279 | R>H | No | 1000Genomes | |
| tmp_3_1857507_C_G | 280 | E>Q | No | 1000Genomes | |
| tmp_3_1857473_G_C | 291 | S>W | No | 1000Genomes | |
| ENSVATH00308819 | 292 | G>C | No | 1000Genomes | |
| ENSVATH13877242 | 297 | G>A | No | 1000Genomes | |
| ENSVATH05781247 | 304 | I>V | No | 1000Genomes | |
| ENSVATH05781246 | 320 | L>F | No | 1000Genomes | |
| tmp_3_1857078_A_G | 332 | L>P | No | 1000Genomes | |
| tmp_3_1857013_T_G | 354 | S>R | No | 1000Genomes |
No associated diseases with Q8LA32
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.27 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. |
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9LYW5 | LUL1 | Probable E3 ubiquitin-protein ligase LUL1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGISFSNNNR | RRDNNNRRHL | HHYPPPPPYY | YLDPPPPPPP | FPPHYDYNYS | NYHLSPPLPP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QPQINSCSYG | HYHYHPQPPQ | YFTTAQPNWW | GPMMRPAYYC | PPQPQTQPPK | PYLEQQNAKK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VRNDVNVHRD | TVRLEVDDLV | PGHHLVSFVF | DALFDGSFTI | TFFAKEEPNC | TIIPQFPEVY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SPTRFHFQKG | PGQKFLQPSG | TGTDLSFFVL | DDLSKPLEED | VYPLVISAET | IISPNSISEQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SSVHKQVTQA | VLEKDNDGSF | KVKVVKQILW | IEGVRYELRE | LYGSTTQGAA | SGLDESGSGT |
| 310 | 320 | 330 | 340 | 350 | |
| ECVICMTEAK | DTAVLPCRHL | CMCSDCAKEL | RLQSNKCPIC | RQPIEELLEI | KMNSSDEQH |