AiPD: Autoinhibited Protein Database

Gene name	PANK2 (At4g32180, F10M6.180, F10N7.10)
Protein name	Pantothenate kinase 2
Names	AtPANK2, Pantothenic acid kinase 2
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT4G32180
EC number	2.7.1.33: Phosphotransferases with an alcohol group as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-94 (Predicted disordered autoinhibitory region) PR

1-94 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8L5Y9-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_4_15543689_A_C	9	D>E	No	1000Genomes
ENSVATH02950161	12	L>H	No	1000Genomes
tmp_4_15543671_T_A	15	K>N	No	1000Genomes
ENSVATH14324703	16	R>K	No	1000Genomes
tmp_4_15543612_G_T	35	S>Y	No	1000Genomes
ENSVATH14324701	100	Y>F	No	1000Genomes
tmp_4_15543177_T_C	124	S>G	No	1000Genomes
tmp_4_15542623_A_C	184	F>C	No	1000Genomes
tmp_4_15542196_C_T	226	G>S	No	1000Genomes
ENSVATH14324694	340	D>G	No	1000Genomes
tmp_4_15541256_C_T	374	R>Q	No	1000Genomes
tmp_4_15540131_A_G	483	M>T	No	1000Genomes
ENSVATH06811204	560	D>H	No	1000Genomes
ENSVATH14324672	710	E>V	No	1000Genomes
tmp_4_15538670_C_T	717	G>S	No	1000Genomes
ENSVATH14324671	721	H>Y	No	1000Genomes
ENSVATH00548019	722	R>L	No	1000Genomes
tmp_4_15538637_G_C	728	L>V	No	1000Genomes
tmp_4_15538183_C_A	810	K>N	No	1000Genomes
ENSVATH02950151	901	L>I	No	1000Genomes

Type	Name	Position	InterPro Accession
domain	Damage-control phosphatase ARMT1-like, metal-binding domain	608 - 886	IPR002791

		Description
EC Number	2.7.1.33	Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
hydrolase activity	Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
metal ion binding	Binding to a metal ion.
pantothenate kinase activity	Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate.

Name	Definition
coenzyme A biosynthetic process	The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
phosphorylation	The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O80765	PANK1	Pantothenate kinase 1	Arabidopsis thaliana (Mouse-ear cress)	PR