AiPD: Autoinhibited Protein Database

Gene name	PANK1 (COAA, At1g60440, T13D8.31)
Protein name	Pantothenate kinase 1
Names	AtPANK1, AtCoaA, Pantothenic acid kinase 1
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT1G60440
EC number	2.7.1.33: Phosphotransferases with an alcohol group as acceptor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

212-282 (Predicted disordered autoinhibitory region) PR

212-282 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-O80765-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_1_22269054_A_G	6	I>T	No	1000Genomes
tmp_1_22268869_C_G	31	E>Q	No	1000Genomes
tmp_1_22268831_C_A	43	R>S	No	1000Genomes
ENSVATH00107863	45	C>Y	No	1000Genomes
tmp_1_22268801_C_A	53	K>N	No	1000Genomes
ENSVATH00107861	67	H>D	No	1000Genomes
tmp_1_22268752_C_G	70	G>R	No	1000Genomes
ENSVATH13668041	71	V>L	No	1000Genomes
ENSVATH00107858	76	G>D	No	1000Genomes
ENSVATH01411417	78	G>D	No	1000Genomes
ENSVATH07662346	94	F>Y	No	1000Genomes
tmp_1_22268394_T_C	99	K>E	No	1000Genomes
ENSVATH00107853	139	K>E	No	1000Genomes
ENSVATH14367277	221	G>S	No	1000Genomes
tmp_1_22267281_C_T	242	A>T	No	1000Genomes
ENSVATH00107836	339	H>L	No	1000Genomes
tmp_1_22266790_G_A	339	H>Y	No	1000Genomes
ENSVATH05010812	344	P>Q	No	1000Genomes
tmp_1_22266753_C_T	351	R>K	No	1000Genomes
tmp_1_22266738_C_G	356	C>S	No	1000Genomes
ENSVATH00107835	361	F>L	No	1000Genomes
ENSVATH05010811	369	N>H	No	1000Genomes
tmp_1_22266657_A_T	383	V>D	No	1000Genomes
ENSVATH05010809	383	V>F	No	1000Genomes
ENSVATH05010809	383	V>L	No	1000Genomes

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for O80765

		Description
EC Number	2.7.1.33	Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
pantothenate kinase activity	Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate.

Name	Definition
coenzyme A biosynthetic process	The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
phosphorylation	The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8L5Y9	PANK2	Pantothenate kinase 2	Arabidopsis thaliana (Mouse-ear cress)	PR