Q8K582

PR
Gene name
Dus1l (Pp3111)
Protein name
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like
Names
Liver regeneration-related protein LRRG08/LRRG09, tRNA-dihydrouridine synthase 1-like
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:246185
EC number
1.3.1.88: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

331-406 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8K582

Entry ID Method Resolution Chain Position Source
AF-Q8K582-F1 Predicted AlphaFoldDB

No variants for Q8K582

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8K582

No associated diseases with Q8K582

1 regional properties for Q8K582

Type Name Position InterPro Accession
domain Luciferase-like domain 4 - 326 IPR011251

Functions

Description
EC Number 1.3.1.88 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
tRNA dihydrouridine synthase activity Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor.

1 GO annotations of biological process

Name Definition
tRNA dihydrouridine synthesis The process whereby a uridine in a transfer RNA is converted to dihydrouridine.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6P1R4 DUS1L tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like Homo sapiens (Human) PR
Q8C2P3 Dus1l tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like Mus musculus (Mouse) PR
10 20 30 40 50 60
MPKLQGFEFW SRALGGARHV VAPMVDQSEL AWRLLSRRHG AQLCYTPMLH AQVFVRDANY
70 80 90 100 110 120
RKENLYCDVC PEDRPLIVQF CANDPEVFVQ AALLAQDYCD AIDLNLGCPQ MIAKRGRYGA
130 140 150 160 170 180
FLQEEWDLLQ RMILLAHERL SVPVTCKIRV FPEIDKTVRY AQMLEKAGCQ LLTVHGRTKE
190 200 210 220 230 240
QKGPMAGTAS WEHIKAVRKA VGIPVFANGN IRCLQDVERC IQDTGVQGVM SAEGNLHNPA
250 260 270 280 290 300
LFEGRSPAVW ELADEYLDIV RQHPCPLSYV RAHLFKLWHH TLQVHQQLRE ELAKVKTLEG
310 320 330 340 350 360
VAAVSQALKL RCQEDMARQQ EGVRPADNLP AFHWICQPYI RPGPKEGSKE NSSGRSKRAL
370 380 390 400 410 420
EEEEGSMEGL SKNKLKKQLR NPHKTFDPSL KPKYAKCDQC GNPKGNRCVF NLCRGCCKKR
430
AFRETADCPG HDCFLRPN