Q8C2P3
Gene name |
Dus1l |
Protein name |
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like |
Names |
tRNA-dihydrouridine synthase 1-like |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:68730 |
EC number |
1.3.1.88: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8C2P3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8C2P3-F1 | Predicted | AlphaFoldDB |
21 variants for Q8C2P3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389226430 | 24 | M>R | No | EVA | |
| rs3389224559 | 30 | L>V | No | EVA | |
| rs3389234470 | 42 | Q>K | No | EVA | |
| rs3413110843 | 67 | C>* | No | EVA | |
| rs3389196062 | 92 | A>V | No | EVA | |
| rs3389188298 | 109 | P>S | No | EVA | |
| rs215687732 | 117 | H>R | No | EVA | |
| rs3389242529 | 166 | K>* | No | EVA | |
| rs3401618454 | 171 | L>C | No | EVA | |
| rs3389242487 | 193 | H>Y | No | EVA | |
| rs3389223562 | 226 | V>A | No | EVA | |
| rs3403169870 | 242 | F>I | No | EVA | |
| rs3402885772 | 242 | F>L | No | EVA | |
| rs3402865884 | 242 | F>Y | No | EVA | |
| rs3389229887 | 259 | I>N | No | EVA | |
| rs3389214348 | 322 | G>* | No | EVA | |
| rs246105643 | 328 | N>D | No | EVA | |
| rs3389223594 | 409 | V>L | No | EVA | |
| rs3389219553 | 455 | A>G | No | EVA | |
| rs3389242558 | 457 | Q>H | No | EVA | |
| rs3389199475 | 474 | L>P | No | EVA |
No associated diseases with Q8C2P3
Functions
| Description | ||
|---|---|---|
| EC Number | 1.3.1.88 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| flavin adenine dinucleotide binding | Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. |
| tRNA dihydrouridine synthase activity | Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA dihydrouridine synthesis | The process whereby a uridine in a transfer RNA is converted to dihydrouridine. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPKLQGFEFW | SRTLGGARHV | VAPMVDQSEL | AWRLLSRRHG | AQLCYTPMLH | AQVFVRDANY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RKENLYCDVC | PEDRPLIVQF | CANDPEVFVQ | AALLAQDYCD | AIDLNLGCPQ | MIAKRGHYGA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FLQEEWDLLQ | RMILLAHERL | SVPVTCKIRV | FPEIDKTVRY | AQMLEKAGCQ | LLTVHGRTKE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QKGPMAGTAS | WEHIKAVRKA | VGIPVFANGN | IQCLQDVERC | IQDTGVQGVM | SAEGNLHNPA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LFEGRSPAVW | ELAEEYLDIV | RQHPCPLSYV | RAHLFKLWHH | TLQVHQQLRE | ELAKVKTLEG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VAAVSQALKL | RCQEDMSRQQ | EGVRPADNLP | AFHWICQPYI | RPGPREGSKE | NSGGRSKRAL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EEEEGSMEGL | SKNKLKKQLR | NPHKTFDPSL | KPKYAKCDQC | GNPKGNRCVF | NLCRGCCKKR |
| 430 | 440 | 450 | 460 | 470 | |
| AFRETADCPG | HGLLFKTKLE | KSLAWKGTQP | GLQEAQQVRP | VTPSGFSEVV | GSALA |