Q8K2Z4

PR
Gene name
Ncapd2 (Capd2, Cnap1, Kiaa0159)
Protein name
Condensin complex subunit 1
Names
Chromosome condensation-related SMC-associated protein 1, Chromosome-associated protein D2, mCAP-D2, Non-SMC condensin I complex subunit D2, XCAP-D2 homolog
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:68298
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1285-1392 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8K2Z4

Entry ID Method Resolution Chain Position Source
AF-Q8K2Z4-F1 Predicted AlphaFoldDB

No variants for Q8K2Z4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8K2Z4

No associated diseases with Q8K2Z4

2 regional properties for Q8K2Z4

Type Name Position InterPro Accession
domain Condensin complex subunit 1, N-terminal 77 - 240 IPR024324
domain Condensin complex subunit 1, C-terminal 1061 - 1221 IPR032682

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Chromosome
  • In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin
  • A subpopulation of the complex however remains associated with chromosome foci in interphase cells
  • During mitosis, most of the condensin complex is associated with the chromatin
  • At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation
  • Dissociation from chromosomes is observed in late telophase (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
condensed chromosome A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.
condensed chromosome, centromeric region The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
condensed nuclear chromosome A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
condensin complex A multisubunit protein complex that plays a central role in chromosome condensation in meiosis and mitosis.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear chromosome A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
pronucleus The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents.

1 GO annotations of molecular function

Name Definition
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.

6 GO annotations of biological process

Name Definition
cell division The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
meiotic chromosome condensation Compaction of chromatin structure prior to meiosis in eukaryotic cells.
mitotic chromosome condensation The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.
positive regulation of chromosome condensation Any process that activates or increases the frequency, rate or extent of chromosome condensation.
positive regulation of chromosome segregation Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.
positive regulation of chromosome separation Any process that activates or increases the frequency, rate or extent of chromosome separation.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q15021 NCAPD2 Condensin complex subunit 1 Homo sapiens (Human) PR
10 20 30 40 50 60
MSPHNFEFHL PLSPEELLKS GGVNQYVVRE VLPVKHLSSQ LRAFQSAFRA QGPLAILEHF
70 80 90 100 110 120
DTVYSILHHF RSIEPGLKED TLEFLKKVVS RHSQELSSIL DDAALSGSDR SAHLNALKMN
130 140 150 160 170 180
CYALIRLLES FENMTSQTSL IDLDIGGKGK RARAKATLGF DWEEERQPVL QLLTQLLQLD
190 200 210 220 230 240
IRHLWNHSAI EEEFVSLVTG CCYRLLENPT ISHQKNRSTK EAIAHLLGVA LVRYNHMLSA
250 260 270 280 290 300
TVKIIQMLQH FEHLPPVLVT AVSLWATDYG MKSIVGEIVR EIGQKCPQEL SRDTAGAKGF
310 320 330 340 350 360
AAFLTELAER IPAVLMANMC ILLDHLDGEN YMMRNAVLAA IAEMVLQVLN GDQLEESARE
370 380 390 400 410 420
TRDQFLDILQ AHGHDVNSFV RSRVLQLFAR IVQQKALPLT RFQAVVALAV GRLADKSVLV
430 440 450 460 470 480
CKNAIQLLAS FLANNPFSCK LSDIDLAGPL QKEIQKLQEM RAQRRSAAAT AALDPEEEWD
490 500 510 520 530 540
AMLPELKSTL QQLLKLPQEE GDHQIADAET AEEVKGRIRQ LLAKASYKQA IVLTREATSH
550 560 570 580 590 600
FQESEPFSHT EPEENSFLNL LGLIFKGPEA STQDSHGDTD PGLTGSKDSP SVPEPEGSQS
610 620 630 640 650 660
NDELVKQEML VQYLQDAYGF SQKITEAIGI ISKMMYENTT TVVQEVIEFF VMVFQFGVPQ
670 680 690 700 710 720
ALFGVRRMLP LIWSKEPGVR EAVLNAYRQL YLNPKGDSAR AKAQTLIHNL SLLLVDASVG
730 740 750 760 770 780
TIQCLEEILC EFVQKDEVKP AVIQLLWERA TEKVPSSPLE RCSSVMLLGM MARGKPEIVG
790 800 810 820 830 840
SNLDALVRVG LDEKSPQDYR LAQQVCLAIA NISDRRKPSL GERHPPFRLP QEHRLFERLQ
850 860 870 880 890 900
DMVTKGFAHP DPLWIPFKEV AVTLTYQLAE SPDVLCAQML QGCAKQVLEK LEKNATEADP
910 920 930 940 950 960
KETAPRLPTF LLMNLLSLAG DVALQQLVHL EQAVSGELGR RRVLREEQEH RAKEPKEKTA
970 980 990 1000 1010 1020
SSETTMEEEL GLVGGATADD TEAELIRSIC EKELLDGNQV LAAFVPLLLK VCNNPGLYSN
1030 1040 1050 1060 1070 1080
PELCAAASLA LGKFCMISAP FCDSQLRLLF TMLEKSSLPT VRSNLMVATG DLAIRFPNLV
1090 1100 1110 1120 1130 1140
DPWTPHLYAR LRDPAQQVRK TAGLVMTHLI LKDMVKVKGQ VSEMAVLLID PVPQIAALAK
1150 1160 1170 1180 1190 1200
NFFNELSHKG NAIYNLLPDI ISRLSDPEGG VEEEPFHTIM KQLLSYITKD KQTESLVEKL
1210 1220 1230 1240 1250 1260
CQRFRTARTE RQYRDLAYCM SQLPLTERGL QKMLDNFECF GDKLLDESVF SAFLSIVGKL
1270 1280 1290 1300 1310 1320
RRGAKPEGKA IIDEFEQKLR ACHTRGMDGI EEFETGQGGS QRALSAKKPS AVSRLQPLTS
1330 1340 1350 1360 1370 1380
VDSDNDFVTP KPRRTKPGRP QTQQRKKSQR KAKVVFLSDE SSEDELSAEM TEEETPKRTT
1390
PIRRASGRRH RS