Q8K1I3
Gene name |
Spp2 (Spp24) |
Protein name |
Secreted phosphoprotein 24 |
Names |
Spp-24, Secreted phosphoprotein 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:75396 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8K1I3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8K1I3-F1 | Predicted | AlphaFoldDB |
12 variants for Q8K1I3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388485090 | 11 | L>W | No | EVA | |
| rs3388490075 | 13 | V>M | No | EVA | |
| rs3388487437 | 30 | D>Y | No | EVA | |
| rs234416804 | 57 | A>V | No | EVA | |
| rs3388486683 | 66 | N>D | No | EVA | |
| rs3388487682 | 70 | E>K | No | EVA | |
| rs1134401112 | 104 | V>A | No | EVA | |
| rs13467463 | 113 | V>M | No | EVA | |
| rs3388486843 | 140 | E>Q | No | EVA | |
| rs3388488507 | 146 | M>L | No | EVA | |
| rs215415146 | 168 | E>G | No | EVA | |
| rs228337756 | 185 | A>T | No | EVA |
No associated diseases with Q8K1I3
No regional properties for Q8K1I3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8K1I3 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| bone remodeling | The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. |
| protein-containing complex assembly | The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q13103 | SPP2 | Secreted phosphoprotein 24 | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEQAMLKTLA | LLVLGMHYWC | ATGFPVYDYD | PSSLQEALSA | SVAKVNSQSL | SPYLFRATRS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SLKRVNVLDE | DTLVMNLEFS | VQETTCLRDS | GDPSTCAFQR | GYSVPTAACR | STVQMSKGQV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KDVWAHCRWA | SSSESNSSEE | MMFGDMARSH | RRRNDYLLGF | LSDESRSEQF | RDRSLEIMRR |
| 190 | 200 | ||||
| GQPPAHRRFL | NLHRRARVNS | GFE |