AiPD: Autoinhibited Protein Database

Q13103

Gene name	SPP2 (SPP24)
Protein name	Secreted phosphoprotein 24
Names	Spp-24, Secreted phosphoprotein 2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:6694
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

62-211 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

62-211 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q13103

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q13103-F1	Predicted				AlphaFoldDB

219 variants for Q13103

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs200097563 CA2183148 RCV002563918 RCV001238608	110	Y>D	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA2183248 rs776382313 RCV002541897 RCV001299612	179	Y>C	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA2183280 rs201364588 RCV002567889 RCV001233829	201	R>Q	Inborn genetic diseases [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs754698489 CA2183037	2	I>T		No	ClinGen ExAC gnomAD
rs1297296795 CA351098107	2	I>V		No	ClinGen TOPMed
CA351098140 rs907542594	4	R>G		No	ClinGen TOPMed gnomAD
rs961916943 CA67654020	6	E>G		No	ClinGen gnomAD
CA351098208 rs1574818367	7	K>N		No	ClinGen Ensembl
rs764495146 CA2183038	7	K>R		No	ClinGen ExAC gnomAD
rs764495146 CA351098203	7	K>T		No	ClinGen ExAC gnomAD
CA351098239 CA2183039 rs751978185	8	M>I		No	ClinGen ExAC gnomAD
rs145529777 RCV001247023 CA2183040	9	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ClinVar ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD
CA67654030 rs145529777	9	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs756261230 CA2183043 COSM1227423	10	M>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1384808982 CA351098332	11	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA351098292 rs1173127457	11	M>K		No	ClinGen TOPMed
CA67654040 rs969449013	12	M>T		No	ClinGen TOPMed
rs1181473550 CA351098395	14	I>M		No	ClinGen Ensembl
rs374261845 CA351098443	16	I>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1490945405 CA351098461	17	M>T		No	ClinGen TOPMed
rs142286393 CA2183045	18	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs768883172 CA2183046	19	A>T		No	ClinGen ExAC gnomAD
rs774124885 CA2183047	19	A>V		No	ClinGen ExAC gnomAD
CA351098551 rs1410057925	20	L>I		No	ClinGen gnomAD
CA2183048 rs747992652	21	G>R		No	ClinGen ExAC gnomAD
rs963615754 COSM442531 CA67654060	22	M>I	breast [Cosmic]	No	ClinGen cosmic curated TOPMed
TCGA novel	22	M>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369178666 CA2183049	22	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA351098699 rs1209574905	25	W>*		No	ClinGen TOPMed gnomAD
RCV001247444 rs1693476656	25	W>CP		No	ClinVar dbSNP
rs760561082 CA2183051	27	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA351099371 rs1377115981	32	V>A		No	ClinGen gnomAD
CA351099382 rs1395662793	33	Y>H		No	ClinGen TOPMed gnomAD
rs766849944 CA2183078	34	D>E		No	ClinGen ExAC gnomAD
CA2183077 rs761181418	34	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs115788299 CA2183081	36	D>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs755087069 CA2183080 COSM233487	36	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs755087069 CA351099452	36	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA67654204 rs1001689642	37	P>Q		No	ClinGen Ensembl
TCGA novel	37	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2183083 rs758562666 RCV001317355	38	S>A		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA2183084 RCV000962958 VAR_025698 rs34347825	38	S>F		No	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA2183086 rs770888198	39	S>F		No	ClinGen ExAC gnomAD
RCV001319726 rs200706917 CA2183087	40	L>F		No	ClinGen ClinVar ExAC dbSNP gnomAD
rs1176491507 CA351099504	40	L>I		No	ClinGen TOPMed gnomAD
rs768201739 CA2183092	42	D>E		No	ClinGen ExAC TOPMed gnomAD
CA2183090 rs114861790 RCV001041593	42	D>N		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
CA2183091 rs762613674	42	D>V		No	ClinGen ExAC gnomAD
rs1381567555 CA351099666	46	A>S		No	ClinGen TOPMed gnomAD
CA351099713 rs1444875439	48	V>A		No	ClinGen TOPMed gnomAD
CA351099709 rs1444875439	48	V>E		No	ClinGen TOPMed gnomAD
CA2183095 rs773609583	51	V>A		No	ClinGen ExAC gnomAD
CA67654232 rs760990067	52	N>I		No	ClinGen ExAC gnomAD
CA2183096 rs760990067	52	N>S		No	ClinGen ExAC gnomAD
rs144683165 RCV001233878 CA2183097	53	S>C		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA2183098 rs551029738	54	Q>*		No	ClinGen 1000Genomes ExAC gnomAD
rs1574818825 CA351099857	55	S>A		No	ClinGen Ensembl
rs1312138678 CA351099863	55	S>L		No	ClinGen gnomAD
TCGA novel	55	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs961742512 CA67654239	56	L>P		No	ClinGen TOPMed
TCGA novel	57	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs143082886 CA2183099	58	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA2183105 rs757044100	62	R>L		No	ClinGen ExAC TOPMed gnomAD
COSM247574 CA67654263 rs757044100	62	R>Q	Variant assessed as Somatic; 0.0 impact. prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs200722650 CA2183104	62	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA2183108 rs536799951	66	S>N		No	ClinGen 1000Genomes ExAC gnomAD
CA351100098 rs1387657136	66	S>R		No	ClinGen TOPMed
CA351100155 rs1160051287	68	L>S		No	ClinGen TOPMed
CA351100170 rs1417434951	69	K>*		No	ClinGen TOPMed
CA2183124 rs767366023	71	V>A		No	ClinGen ExAC gnomAD
rs767366023 CA67658148	71	V>D		No	ClinGen ExAC gnomAD
rs757524498 CA2183123	71	V>F		No	ClinGen ExAC gnomAD
CA351101621 rs1339105286	72	E>K		No	ClinGen gnomAD
rs750252210 COSM574321 CA2183125	73	V>F	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA67658150 rs962560054	73	V>G		No	ClinGen Ensembl
CA2183126 rs756119652	74	L>P		No	ClinGen ExAC gnomAD
rs780185360 CA2183127	76	E>D		No	ClinGen ExAC gnomAD
rs763033241 CA2183129	77	N>K		No	ClinGen ExAC gnomAD
CA2183128 rs371778962	77	N>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs1300520957 CA351101702	78	N>D		No	ClinGen TOPMed
CA67658162 rs967652923	80	V>F		No	ClinGen TOPMed
CA67658165 CA67658173 rs779147902	81	M>I		No	ClinGen Ensembl
CA2183130 rs778504483	81	M>R		No	ClinGen ExAC gnomAD
rs556366714 CA2183131	82	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA351101802 rs1270887663	83	L>S		No	ClinGen gnomAD
rs771714862 CA2183132	87	I>T		No	ClinGen ExAC gnomAD
rs746289744 CA351101862	88	R>L		No	ClinGen ExAC TOPMed gnomAD
rs746289744 COSM1291464 CA2183134	88	R>Q	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA2183133 rs149868175	88	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA2183135 rs770265381	89	E>K		No	ClinGen ExAC gnomAD
CA67658189 rs983853757	91	T>R		No	ClinGen Ensembl
rs764033769 CA2183138	92	C>*		No	ClinGen ExAC gnomAD
CA2183137 rs763549452 RCV001351403	92	C>R		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs1167352947 CA351101897	92	C>Y		No	ClinGen gnomAD
rs1297018807 CA351101915 RCV001308291	93	R>S		No	ClinGen ClinVar dbSNP gnomAD
CA351101908 rs1399954776	93	R>W		No	ClinGen gnomAD
rs774506787 CA2183139	95	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1282127558 CA351101963	97	G>A		No	ClinGen gnomAD
CA2183142 rs750233905	98	E>D		No	ClinGen ExAC TOPMed gnomAD
rs756010192 CA2183143	99	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1293713918 CA351101982	99	D>H		No	ClinGen gnomAD
CA2183145 rs74975266 RCV001324735	101	A>T		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs754953529 CA2183146	101	A>V		No	ClinGen ExAC gnomAD
rs930417399 CA67658231	102	T>A		No	ClinGen TOPMed
CA67658234 rs944945403	104	A>V		No	ClinGen Ensembl
CA351102115 rs1185521611	108	D>G		No	ClinGen gnomAD
CA351102110 rs1397671213	108	D>Y		No	ClinGen Ensembl
CA67658244 rs886302747	110	Y>C		No	ClinGen TOPMed gnomAD
CA351102159 rs886302747	110	Y>S		No	ClinGen TOPMed gnomAD
rs1340500662 CA351102178	111	V>A		No	ClinGen TOPMed
CA67658886 rs952488913	112	S>F		No	ClinGen Ensembl
CA2183168 rs751165065	112	S>P		No	ClinGen ExAC gnomAD
CA2183170 rs780218526	113	T>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	114	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1213169901 CA351103039	115	V>L		No	ClinGen TOPMed
rs1256332961 CA351103051	116	C>R		No	ClinGen gnomAD
CA2183172 rs769033625	117	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1199625002 CA351103105	119	T>I		No	ClinGen gnomAD
rs141839502 RCV001048183 CA2183174	120	V>M		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA351103154 rs1272410394	123	S>P		No	ClinGen TOPMed
CA67658918 rs1015197391	125	Q>*		No	ClinGen gnomAD
rs1015197391 CA351103178	125	Q>E		No	ClinGen gnomAD
rs772225535 CA2183176	125	Q>P		No	ClinGen ExAC gnomAD
rs199501024 CA2183177	127	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
RCV001046913 CA2183180 rs202217477	130	V>M		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA2183181 rs759424087	132	A>P		No	ClinGen ExAC gnomAD
RCV001234407 rs575965941 CA2183182	133	R>C		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
CA2183183 COSM1732555 rs376262894	133	R>H	Variant assessed as Somatic; 0.0 impact. NS [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA2183184 RCV001314500 rs376262894	133	R>P		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA2183185 rs150395122	135	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA351103320 rs200554838	136	W>*		No	ClinGen TOPMed gnomAD
rs200554838 CA67658937 RCV001323887	136	W>C		No	ClinGen ClinVar TOPMed dbSNP gnomAD
CA67658939 rs768729113	137	S>F		No	ClinGen gnomAD
TCGA novel	137	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs868200925 CA351103330	138	S>F		No	ClinGen gnomAD
rs868200925 CA67658955	138	S>Y		No	ClinGen gnomAD
CA351103334 rs1559173877	139	S>A		No	ClinGen Ensembl
rs756858234 CA2183187 RCV001346223	140	T>M		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
rs369042998 CA67658978	142	E>D		No	ClinGen ESP gnomAD
rs1490992575 CA351103370	143	S>C		No	ClinGen gnomAD
rs138191546 CA351103387	144	Y>*		No	ClinGen ESP ExAC gnomAD
rs755325619 CA2183190	144	Y>H		No	ClinGen ExAC gnomAD
TCGA novel	145	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
RCV001299295 CA351103410 rs1477272388	146	S>G		No	ClinGen ClinVar dbSNP gnomAD
rs748604950 CA351103423	146	S>R		No	ClinGen ExAC TOPMed gnomAD
rs777994744 CA2183194	147	E>A		No	ClinGen ExAC
CA351103425 rs541421017	147	E>K		No	ClinGen 1000Genomes ExAC gnomAD
CA2183193 rs541421017	147	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
CA351104594 rs1318053482	149	M>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1215833498 CA351104618	150	I>T		No	ClinGen gnomAD
TCGA novel	151	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs139040392 CA2183216	151	F>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2183217 rs769915377	152	G>E		No	ClinGen ExAC gnomAD
rs1446167298 CA351104745	154	M>I		No	ClinGen gnomAD
rs775263458 CA2183218	154	M>L		No	ClinGen ExAC TOPMed gnomAD
CA351104737 rs1243526450	154	M>T		No	ClinGen gnomAD
rs775263458 CA351104730	154	M>V		No	ClinGen ExAC TOPMed gnomAD
CA2183220 rs768562382	156	G>A		No	ClinGen ExAC gnomAD
rs575643795 CA67661727	158	H>Y		No	ClinGen 1000Genomes
rs1490808213 CA351104826	160	W>R		No	ClinGen gnomAD
RCV001305299 rs375850205 CA2183221	161	R>I		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP
RCV001306899 rs1559176718	162	N>missing		No	ClinVar dbSNP
CA351104865 rs1161349909	162	N>H		No	ClinGen gnomAD
RCV001337589 rs1376035537 CA351104882	163	N>D		No	ClinGen ClinVar dbSNP gnomAD
CA351104894 rs1465725762	163	N>K		No	ClinGen gnomAD
TCGA novel	163	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs141694000 CA2183223	164	Y>*		No	ClinGen ESP ExAC TOPMed gnomAD
COSM384396 rs1408593199 CA351104916	165	L>I	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
CA351104948 rs1168309743	166	F>L		No	ClinGen TOPMed
CA351105107 rs1380880592	168	L>V		No	ClinGen TOPMed
CA2183243 rs771966866	171	D>V		No	ClinGen ExAC gnomAD
TCGA novel	172	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA351105188 rs1237354656	172	E>D		No	ClinGen TOPMed
CA2183245 rs147173896 RCV001044827	172	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ClinVar ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD
CA2183246 rs770675713	174	I>V		No	ClinGen ExAC gnomAD
rs1559177037 CA351105265	177	Q>*		No	ClinGen Ensembl
RCV001342778 rs758307599	177	Q>H		No	ClinVar dbSNP
TCGA novel	177	Q>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	178	F>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA351105289 rs1163155420	180	D>A		No	ClinGen gnomAD
CA351105294 rs375462993	181	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA2183250 COSM574319 RCV001344392 rs764495552	181	R>Q	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ClinVar ExAC NCI-TCGA TOPMed dbSNP gnomAD
RCV001228929 CA2183249 rs375462993 COSM1018208	181	R>W	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ClinVar ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD
CA67662142 rs867276641	183	L>F		No	ClinGen Ensembl
rs777609841 CA2183264	184	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
RCV001233012 rs191672392 CA2183265	185	I>N		No	ClinGen ClinVar 1000Genomes ExAC dbSNP gnomAD
rs1262221943 CA351105947	186	M>I		No	ClinGen gnomAD
rs776285212 CA2183267	186	M>R		No	ClinGen ExAC TOPMed gnomAD
CA351105937 rs1206652136	186	M>V		No	ClinGen gnomAD
CA351105952 rs1246612600	187	R>G		No	ClinGen gnomAD
RCV001242951 rs1693900246	187	R>T		No	ClinVar dbSNP
rs1317007899 CA351106000	189	V>A		No	ClinGen gnomAD
CA67663416 rs993016427	189	V>I		No	ClinGen gnomAD
CA351105995 rs993016427	189	V>L		No	ClinGen gnomAD
CA2183268 rs759206824	191	P>S		No	ClinGen ExAC gnomAD
CA67663433 RCV001302049 rs915089963	192	P>L		No	ClinGen ClinVar TOPMed dbSNP gnomAD
rs1285101988 CA351106049	192	P>S		No	ClinGen gnomAD
CA351106096 rs1371359951	194	N>K		No	ClinGen TOPMed
rs769627245 CA2183269	194	N>S		No	ClinGen ExAC gnomAD
rs1294774034 CA351106101	195	R>*		No	ClinGen TOPMed
rs774770808 CA351106147	196	R>S		No	ClinGen ExAC gnomAD
rs750842592 CA2183274 CA67663442 RCV001066315	197	Y>*		No	ClinGen ClinVar ExAC TOPMed dbSNP gnomAD
CA2183273 rs762122267	197	Y>H		No	ClinGen ExAC gnomAD
rs762122267 CA2183272	197	Y>N		No	ClinGen ExAC gnomAD
rs761197403 CA2183275	198	P>S		No	ClinGen ExAC TOPMed gnomAD
CA2183276 rs766392250	199	N>K		No	ClinGen ExAC
CA67663457 rs576448634	200	H>Y		No	ClinGen Ensembl
CA2183278 rs201489523	201	R>G		No	ClinGen ExAC TOPMed gnomAD
rs201364588 CA351106231	201	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs201364588 CA2183279 RCV001322961	201	R>P		No	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA2183277 rs201489523	201	R>W		No	ClinGen ExAC TOPMed gnomAD
CA2183283 rs746877413	204	A>G		No	ClinGen ExAC TOPMed gnomAD
rs777655279 CA2183282 COSM1018209	204	A>S	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA67663476 rs746877413	204	A>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	205	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757273882 CA2183284	205	R>K		No	ClinGen ExAC TOPMed gnomAD
rs1338478634 CA351106292	206	I>V		No	ClinGen gnomAD
CA351106301 rs1374538194	207	N>H		No	ClinGen gnomAD
CA351106330 rs1207190218	209	D>G		No	ClinGen TOPMed

No associated diseases with Q13103

No regional properties for Q13103

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q13103

Functions

		Description
EC Number
Subcellular Localization	Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
collagen-containing extracellular matrix	An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
endoplasmic reticulum lumen	The volume enclosed by the membranes of the endoplasmic reticulum.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
platelet dense granule lumen	The volume enclosed by the membrane of the platelet dense granule.

1 GO annotations of molecular function

Name	Definition
endopeptidase inhibitor activity	Binds to and stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

2 GO annotations of biological process

Name	Definition
bone remodeling	The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.
skeletal system development	The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8K1I3	Spp2	Secreted phosphoprotein 24	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MISRMEKMTM	MMKILIMFAL	GMNYWSCSGF	PVYDYDPSSL	RDALSASVVK	VNSQSLSPYL
70	80	90	100	110	120
FRAFRSSLKR	VEVLDENNLV	MNLEFSIRET	TCRKDSGEDP	ATCAFQRDYY	VSTAVCRSTV
130	140	150	160	170	180
KVSAQQVQGV	HARCSWSSST	SESYSSEEMI	FGDMLGSHKW	RNNYLFGLIS	DESISEQFYD
190	200	210
RSLGIMRRVL	PPGNRRYPNH	RHRARINTDF	E