Q8K1H1
PR
Gene name |
Tdrd7 (Pctaire2bp) |
Protein name |
Tudor domain-containing protein 7 |
Names |
PCTAIRE2-binding protein, Tudor repeat associator with PCTAIRE-2, Trap |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:100121 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q8K1H1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2LH9 | NMR | - | A | 1-76 | PDB |
| 2LY1 | NMR | - | A | 223-400 | PDB |
| 2LY2 | NMR | - | A | 223-400 | PDB |
| AF-Q8K1H1-F1 | Predicted | AlphaFoldDB |
52 variants for Q8K1H1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs250886269 | 64 | A>S | No | EVA | |
| rs3388677735 | 73 | Y>F | No | EVA | |
| rs3388684520 | 76 | A>T | No | EVA | |
| rs3388679944 | 83 | I>V | No | EVA | |
| rs3388686728 | 127 | G>R | No | EVA | |
| rs262052748 | 142 | L>M | No | EVA | |
| rs248926746 | 170 | A>S | No | EVA | |
| rs228392805 | 195 | A>T | No | EVA | |
| rs238402429 | 198 | T>K | No | EVA | |
| rs3388684512 | 248 | H>Y | No | EVA | |
| rs3388686759 | 302 | P>H | No | EVA | |
| rs3393691299 | 309 | P>Q | No | EVA | |
| rs3388669829 | 328 | D>N | No | EVA | |
| rs3388662550 | 333 | V>A | No | EVA | |
| rs3388675884 | 380 | Y>N | No | EVA | |
| rs3388683964 | 385 | T>N | No | EVA | |
| rs3388671893 | 387 | K>* | No | EVA | |
| rs3394245108 | 410 | G>R | No | EVA | |
| rs28309087 | 437 | L>M | No | EVA | |
| rs3388669820 | 442 | V>M | No | EVA | |
| rs3394197297 | 465 | D>N | No | EVA | |
| rs3388683677 | 494 | P>H | No | EVA | |
| rs3388680905 | 529 | K>N | No | EVA | |
| rs3394154624 | 568 | A>H | No | EVA | |
| rs864302548 | 589 | G>A | No | EVA | |
| rs3388684014 | 598 | D>V | No | EVA | |
| rs3388671873 | 601 | D>N | No | EVA | |
| rs3388677815 | 604 | L>M | No | EVA | |
| rs3388675935 | 604 | L>P | No | EVA | |
| rs3388679904 | 708 | R>Q | No | EVA | |
| rs3388677731 | 724 | F>L | No | EVA | |
| rs3388682109 | 761 | L>S | No | EVA | |
| rs3388681220 | 765 | P>Q | No | EVA | |
| rs3388675912 | 766 | Q>H | No | EVA | |
| rs3388677740 | 775 | A>V | No | EVA | |
| rs3388681261 | 782 | S>Y | No | EVA | |
| rs3388677751 | 785 | N>Y | No | EVA | |
| rs28287694 | 796 | M>V | No | EVA | |
| rs3388684654 | 817 | H>N | No | EVA | |
| rs3388677340 | 825 | T>I | No | EVA | |
| rs3388677398 | 826 | N>D | No | EVA | |
| rs3388681272 | 831 | K>E | No | EVA | |
| rs3388686750 | 835 | D>V | No | EVA | |
| rs3388684667 | 879 | D>E | No | EVA | |
| rs3388684516 | 909 | A>G | No | EVA | |
| rs3388677762 | 921 | Q>* | No | EVA | |
| rs3388681266 | 967 | K>R | No | EVA | |
| rs3388681234 | 985 | H>D | No | EVA | |
| rs3388681228 | 999 | V>M | No | EVA | |
| rs3388677374 | 1042 | Q>L | No | EVA | |
| rs3388682162 | 1046 | E>K | No | EVA | |
| rs3388677414 | 1085 | V>I | No | EVA |
No associated diseases with Q8K1H1
9 regional properties for Q8K1H1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Tudor domain | 448 - 569 | IPR002999-1 |
| domain | Tudor domain | 637 - 762 | IPR002999-2 |
| domain | Tudor domain | 898 - 1014 | IPR002999-3 |
| domain | OST-HTH/LOTUS domain | 3 - 76 | IPR025605-1 |
| domain | OST-HTH/LOTUS domain | 222 - 291 | IPR025605-2 |
| domain | OST-HTH/LOTUS domain | 325 - 394 | IPR025605-3 |
| domain | TDRD7, third LOTUS domain | 328 - 392 | IPR037978 |
| domain | TDRD7, second Tudor domain | 641 - 780 | IPR047448 |
| domain | TDRD7, third Tudor domain | 918 - 1008 | IPR047449 |
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromatoid body | A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182). |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| P granule | A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes. |
| ribonucleoprotein complex | A macromolecular complex that contains both RNA and protein molecules. |
| ribonucleoprotein granule | A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| protein N-terminus binding | Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| germ cell development | The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism. |
| lens fiber cell differentiation | The process in which a relatively unspecialized cell acquires specialized features of a lens fiber cell, any of the elongated, tightly packed cells that make up the bulk of the mature lens in the camera-type eye. The cytoplasm of a lens fiber cell is devoid of most intracellular organelles including the cell nucleus, and contains primarily crystallins, a group of water-soluble proteins expressed in vary large quantities. |
| lens morphogenesis in camera-type eye | The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus. |
| P granule organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes. |
| piRNA metabolic process | The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. |
| post-transcriptional regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLEADLVSKM | LRAVLQSHKN | GIVLPRLQGE | YRSLTGDWIP | FKQLGYPTLE | AYLRSVPAVV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RIEASRSGEI | VCYAVACTET | ARIAQLVARQ | RTSKRKIGRQ | INCQMRVKKA | MPFFLEGKPK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ATLRQPGFAS | DYSISRKPNS | ALLRDRGSAL | GVKADVDMPP | YPDTPVQRHA | SMSANSRFSP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KSSLPASFQT | HISRACPTEV | NDNLNQTVEK | PNITPPASYT | NKMDEVQNRI | KEILDKHNNG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IWISKLPHFY | KEFYKEDLNQ | GVLQQFEHWP | HICTVEKPCG | GGQDSLLYPA | RREQPLKSDQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DPEKELPPPP | PAPKQEVPSQ | GSPAVMPDVK | EKVAELLGKY | SSGLWASALP | KAFEDMYKVK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FPEDALKNLA | SLSDVCTINY | ISGNTQKAIL | YAKLPLPTDK | ILKDEGQAQG | DFDIKSMIEQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EYLQIEKNMA | ESADEFLEDI | TVPPLVIPTE | ASPSVLVVEL | SNTNDVVIRY | VGKDYSAAQE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LMEDEMKEFY | SKNPRVTPIQ | TVHVGQLLAV | NAEEDAWLRA | QIISTDENKI | KVCYVDYGFC |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ENIEKSKAYR | LNPRFCSLSF | QATKCKLAGL | EVLNDDPDLV | KAVESLTCGK | IFAVEILDKS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| DVPLVVLYDT | SGEDDININA | TCLKAICDRS | LQVHLQVDAM | YTNVKVTNIC | SDGTLYCQVP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| CKGLNKLNDL | LHKTEDYFHC | KHMTSEYFIS | LPFCGKICLF | HCKGKWLRVE | ITNVHSSRAL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DVQFLDSGNS | TSVKVSELRE | IPPRFLQEML | AIPPQAIKCC | LADLPQSIGM | WTPDAVLWLR |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DSVLNCSDCS | IKVTKMDETK | GVAYVYLFTP | NNFPDPHRSI | NRQITNADLW | KHQKDVFLSA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VSTAASSPGN | RNGGTPAPGS | PAESLRKSHP | EVIKKSVLDH | TSSFSLEELP | PPVHLSRSGE |
| 910 | 920 | 930 | 940 | 950 | 960 |
| HMDVYVPVAC | HPGHFVIQPW | QEIHKLEVLM | EEMILYYSVS | EERHIAVERD | QVYAAKVENK |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| WYRVLLKGIL | TNGLVSVYEL | DYGKHELVNI | RKVQPLVDVF | RKLPFQAVTA | QLAGVKCSQW |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| SEEASMVFRN | HVEKKALVAL | VQTVVEHTNP | WDRKVVLYLV | DTSLPDTDTW | IHDFMSQYLL |
| ELSKVN |