Q8K157
Gene name |
Galm |
Protein name |
Galactose mutarotase |
Names |
Aldose 1-epimerase |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:319625 |
EC number |
5.1.3.3: Acting on carbohydrates and derivatives |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8K157
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8K157-F1 | Predicted | AlphaFoldDB |
26 variants for Q8K157
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389482989 | 16 | G>E | No | EVA | |
| rs3389485271 | 26 | S>L | No | EVA | |
| rs3389429944 | 29 | L>Q | No | EVA | |
| rs255623771 | 39 | T>M | No | EVA | |
| rs3389473711 | 52 | A>P | No | EVA | |
| rs13465097 | 54 | D>G | No | EVA | |
| rs258416517 | 91 | G>S | No | EVA | |
| rs3407023276 | 93 | K>TPSHL* | No | EVA | |
| rs3389485290 | 99 | V>F | No | EVA | |
| rs258577973 | 127 | V>I | No | EVA | |
| rs3389477318 | 133 | S>R | No | EVA | |
| rs245042465 | 194 | V>I | No | EVA | |
| rs108347271 | 207 | T>N | No | EVA | |
| rs240178113 | 211 | T>K | No | EVA | |
| rs226187689 | 232 | T>S | No | EVA | |
| rs3389392451 | 237 | Y>F | No | EVA | |
| rs3389496308 | 239 | I>N | No | EVA | |
| rs33205611 | 260 | V>M | No | EVA | |
| rs3389496310 | 272 | Y>F | No | EVA | |
| rs107765576 | 295 | G>S | No | EVA | |
| rs3389460127 | 303 | G>D | No | EVA | |
| rs3389392425 | 310 | N>K | No | EVA | |
| rs29713752 | 314 | S>A | No | EVA | |
| rs224572719 | 326 | R>G | No | EVA | |
| rs3389440096 | 327 | P>H | No | EVA | |
| rs3389473744 | 336 | W>* | No | EVA |
No associated diseases with Q8K157
1 regional properties for Q8K157
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Aldose 1-epimerase, conserved site | 172 - 181 | IPR018052 |
Functions
| Description | ||
|---|---|---|
| EC Number | 5.1.3.3 | Acting on carbohydrates and derivatives |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| aldose 1-epimerase activity | Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose. |
| carbohydrate binding | Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. |
| hydrolase activity, hydrolyzing O-glycosyl compounds | Catalysis of the hydrolysis of any O-glycosyl bond. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| carbohydrate metabolic process | The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. |
| galactose catabolic process via UDP-galactose | The chemical reactions and pathways resulting in the breakdown of galactose, via the intermediate UDP-galactose. |
| galactose metabolic process | The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. |
| glucose metabolic process | The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVSVTRTVFG | ELPSGGGTVE | KFQLRSDQLS | VDIISWGCTI | TALQVKDRQG | KASDVVLGFA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ELEGYLQKQP | YFGAVVGRVA | NRIAKGRFTI | GGKEYHLPVN | REPNSLHGGF | TGFDKVLWTP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QVLTNGVQFF | RVSPDGEEGY | PGELKVWVTY | TLDGGELVIN | YRAQASQTTP | VNLTNHSYFN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LAGQGSPNIY | DHEVTIAADA | YLPVDETLIP | TGVIAPVEGT | AFDLRKPVEL | GTHLQDYHIH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GFDHNFCLKE | SKEKKFCARV | RHAASGRILE | VYTTQPGVQF | YTGNFLDGTL | KGKNGAVYPK |
| 310 | 320 | 330 | 340 | ||
| HSGLCLETQN | WPDSVNQPQF | PPALLRPGEE | YNHTTWFKFS | VA |