Q8K013

PR
Gene name
Gtpbp10
Protein name
GTP-binding protein 10
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:207704
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

29-122 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8K013

Entry ID Method Resolution Chain Position Source
AF-Q8K013-F1 Predicted AlphaFoldDB

23 variants for Q8K013

Variant ID(s) Position Change Description Diseaes Association Provenance
rs580683088 32 Y>H No EVA
rs3388741157 40 G>E* No EVA
rs3388742499 41 R>* No EVA
rs3388734568 50 H>Q No EVA
rs3388742810 62 Y>N No EVA
rs3388747983 66 R>W No EVA
rs3388728914 70 G>R No EVA
rs3388725397 84 K>M No EVA
rs3388748055 93 P>H No EVA
rs3388746740 107 G>E No EVA
rs3388734633 129 T>I No EVA
rs31010012 130 N>S No EVA
rs3388739461 137 Q>R No EVA
rs3388742206 146 K>E No EVA
rs214069495 267 E>D No EVA
rs256108345 273 A>E No EVA
rs217269711 277 I>V No EVA
rs31010541 284 D>G No EVA
rs3388742530 293 M>L No EVA
rs3388715071 296 L>F No EVA
rs224844722 348 G>S No EVA
rs581004975 358 Q>H No EVA
rs584154571 358 Q>L No EVA

No associated diseases with Q8K013

3 regional properties for Q8K013

Type Name Position InterPro Accession
domain GTP binding domain 150 - 279 IPR006073
domain GTP1/OBG domain 13 - 148 IPR006169
domain OBG-type guanine nucleotide-binding (G) domain 149 - 344 IPR031167

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
  • Found in the dense fibrillar compartment region of the nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
magnesium ion binding Binding to a magnesium (Mg) ion.

1 GO annotations of biological process

Name Definition
ribosome biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5M8V6 gtpbp10 GTP-binding protein 10 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MVRCGCALLR KYGNFIDNLR IFTKGGSGGM GYPRLGGEGG RGGDVWVVAH KNMTLKQLKN
70 80 90 100 110 120
KYPQKRFVAG GGANSRVSAL QGSKGKDCEV PAPVGISVTD ENGQVLGELN KEEDRVLVAK
130 140 150 160 170 180
GGLGGKLHTN FLPLKGQKRI VHLDLKVIAD VGLVGFPNAG KSSLLSRVSH ATPVIADYAF
190 200 210 220 230 240
TTLRPELGKI MYNDFKQISV ADLPGLIEGA HMNKGMGHKF LKHLERTRQL LFVVDISGFQ
250 260 270 280 290 300
LSSVTPYRTA FETIILLTKE LELYKEELQT KPALLAINKM DLPDAQVKLQ ELMKQLLSPE
310 320 330 340 350 360
DFLHLFETKM IPEKALEFQH IVPISTVTGE GIAELKSCIR KALDEQDGKE SDAHRSKQLL
NLQSSS