Q8K007

PR
Gene name
Sulf1 (Kiaa1077)
Protein name
Extracellular sulfatase Sulf-1
Names
mSulf-1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:240725
EC number
3.1.6.1: Sulfuric ester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8K007

Entry ID Method Resolution Chain Position Source
AF-Q8K007-F1 Predicted AlphaFoldDB

35 variants for Q8K007

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388458856 23 S>P No EVA
rs3388457916 29 R>M No EVA
rs3388457785 30 F>L No EVA
rs3388458424 36 Q>R No EVA
rs3388457877 42 R>K No EVA
rs3412825788 59 S>* No EVA
rs3388458314 65 K>N No EVA
rs3388458069 75 A>T No EVA
rs3388458663 79 N>H No EVA
rs3388457879 116 S>L No EVA
rs3388457748 128 V>E No EVA
rs3388457615 145 N>I No EVA
rs3388458248 146 E>K No EVA
rs3388457830 171 Y>N No EVA
rs3388458636 209 M>K No EVA
rs3388458442 236 K>I No EVA
rs3389634918 247 P>H No EVA
rs3388457904 254 N>T No EVA
rs3388458477 257 K>E No EVA
rs3388458695 305 E>V No EVA
rs3388458597 372 A>D No EVA
rs3388458053 405 K>Q No EVA
rs3388457851 437 K>I No EVA
rs3388457851 437 K>R No EVA
rs3388458298 459 Q>* No EVA
rs3388458622 500 K>T No EVA
rs3388457776 521 Q>P No EVA
rs229862359 525 L>P No EVA
rs3388457629 584 I>F No EVA
rs252269444 584 I>S No EVA
rs220120827 675 G>S No EVA
rs230399954 680 S>R No EVA
rs249346052 683 N>D No EVA
rs3388458488 732 Q>* No EVA
rs3388457732 744 T>I No EVA

No associated diseases with Q8K007

1 regional properties for Q8K007

Type Name Position InterPro Accession
binding_site EF-Hand 1, calcium-binding site 20 - 32 IPR018247

Functions

Description
EC Number 3.1.6.1 Sulfuric ester hydrolases
Subcellular Localization
  • Endoplasmic reticulum
  • Golgi apparatus, Golgi stack
  • Cell surface
  • ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cell surface The external part of the cell wall and/or plasma membrane.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi stack The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.
membrane raft Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
arylsulfatase activity Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate.
calcium ion binding Binding to a calcium ion (Ca2+).
glycosaminoglycan binding Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues.
N-acetylglucosamine-6-sulfatase activity Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.

27 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
bone development The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
cartilage condensation The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes.
cartilage development The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
chondrocyte development The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.
embryonic skeletal system development The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.
esophagus smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the esophagus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The esophagus is the muscular membranous segment between the pharynx and the stomach in the upper gastrointestinal tract.
glial cell-derived neurotrophic factor receptor signaling pathway The series of molecular signals initiated by a ligand binding to a glial cell-derived neurotrophic factor receptor.
glomerular basement membrane development The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration.
glomerular filtration The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein.
heparan sulfate proteoglycan metabolic process The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups.
innervation The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue.
kidney development The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
limb joint morphogenesis The process in which the anatomical structures of a limb joint are generated and organized. A limb joint is a flexible region that separates the rigid sections of a limb to allow movement in a controlled manner.
negative regulation of angiogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
negative regulation of cell migration Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
negative regulation of endothelial cell proliferation Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.
negative regulation of fibroblast growth factor receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.
negative regulation of prostatic bud formation Any process that decreases the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth.
positive regulation of BMP signaling pathway Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.
positive regulation of smooth muscle cell proliferation Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
positive regulation of vascular endothelial growth factor production Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor.
positive regulation of Wnt signaling pathway Any process that activates or increases the frequency, rate or extent of Wnt signal transduction.
regulation of fibroblast growth factor receptor signaling pathway Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.
sulfur compound metabolic process The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
vascular endothelial growth factor receptor signaling pathway The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q148F3 ARSK Arylsulfatase K Bos taurus (Bovine) PR
10 20 30 40 50 60
MKYSLWALLL AVLGTQLLGS LCSTVRSQRF RGRIQQERKN IRPNIILVLT DDQDVELGSL
70 80 90 100 110 120
QVMNKTRKIM EQGGATFTNA FVTTPMCCPS RSSMLTGKYV HNHNVYTNNE NCSSPSWQAM
130 140 150 160 170 180
HEPRTFAVYL NNTGYRTAFF GKYLNEYNGS YIPPGWREWL GLIKNSRFYN YTVCRNGIKE
190 200 210 220 230 240
KHGFDYAKDY FTDLITNESI NYFKMSKRMY PHRPIMMVIS HAAPHGPEDS APQFSKLYPN
250 260 270 280 290 300
ASQHITPSYN YAPNMDKHWI MQYTGPMLPI HMEFTNVLQR KRLQTLMSVD DSVERLYNML
310 320 330 340 350 360
VESGELDNTY IIYTADHGYH IGQFGLVKGK SMPYDFDIRV PFFIRGPSIE PGSIVPQIVL
370 380 390 400 410 420
NIDLAPTILD IAGLDSPSDV DGKSVLKLLD LEKPGNRFRT NKKAKIWRDT FLVERGKFLR
430 440 450 460 470 480
KKEESGKNIQ QSNHLPKYER VKELCQQARY QTACEQPGQN WQCIEDTSGK LRIHKCKGPS
490 500 510 520 530 540
DLLTVRQNAR NLYSRGLHDK DKECHCRDSG YRSSRSQRKN QRQFLRNKGT PKYKPRFVHT
550 560 570 580 590 600
RQTRSLSVEF EGEIYDINLE EEELQVLPPR SIAKRHDEGH QGFIGHQAAA GDIRNEMLAD
610 620 630 640 650 660
SNNAVGLPAT VRVTHKCFIL PNDTIHCERE LYQSARAWKD HKAYIDKEIE VLQDKIKNLR
670 680 690 700 710 720
EVRGHLKKRK PEECGCGDQS YYNKEKGVKR QEKLKSHLHP FKEAAAQEVD SKLQLFKEHR
730 740 750 760 770 780
RRKKERKEKK RQRKGEECSL PGLTCFTHDN NHWQTAPFWN LGSFCACTSS NNNTYWCLRT
790 800 810 820 830 840
VNETHNFLFC EFATGFLEYF DMNTDPYQLT NTVHTVERSI LNQLHIQLME LRSCQGYKQC
850 860
NPRPKSLDIG AKEGGNYDPH RGQLWDGWEG