Q148F3
PR
Gene name |
ARSK |
Protein name |
Arylsulfatase K |
Names |
ASK, Glucuronate-2-sulfatase |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
|
EC number |
3.1.6.18: Sulfuric ester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q148F3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q148F3-F1 | Predicted | AlphaFoldDB |
134 variants for Q148F3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs449672723 | 2 | L>Q | No | EVA | |
| rs476765505 | 5 | W>C | No | EVA | |
| rs469723270 | 5 | W>G | No | EVA | |
| rs445602608 | 6 | V>E | No | EVA | |
| rs133861638 | 8 | V>G | No | EVA | |
| rs135112037 | 9 | V>G | No | EVA | |
| rs454847646 | 24 | Q>R | No | EVA | |
| rs437007114 | 28 | A>E | No | EVA | |
| rs437007114 | 28 | A>G | No | EVA | |
| rs476705907 | 29 | I>L | No | EVA | |
| rs452515397 | 29 | I>M | No | EVA | |
| rs438969095 | 29 | I>N | No | EVA | |
| rs438969095 | 29 | I>S | No | EVA | |
| rs472667042 | 30 | Q>* | No | EVA | |
| rs472667042 | 30 | Q>E | No | EVA | |
| rs461680004 | 30 | Q>H | No | EVA | |
| rs472667042 | 30 | Q>K | No | EVA | |
| rs441467315 | 30 | Q>L | No | EVA | |
| rs441467315 | 30 | Q>P | No | EVA | |
| rs481639637 | 31 | A>D | No | EVA | |
| rs481639637 | 31 | A>G | No | EVA | |
| rs445741486 | 32 | W>C | No | EVA | |
| rs476898448 | 32 | W>L | No | EVA | |
| rs463239112 | 32 | W>R | No | EVA | |
| rs465577137 | 33 | P>A | No | EVA | |
| rs479482680 | 33 | P>H | No | EVA | |
| rs479482680 | 33 | P>R | No | EVA | |
| rs465577137 | 33 | P>S | No | EVA | |
| rs436935220 | 34 | D>A | No | EVA | |
| rs457123166 | 34 | D>E | No | EVA | |
| rs436935220 | 34 | D>G | No | EVA | |
| rs468509382 | 34 | D>H | No | EVA | |
| rs432427761 | 35 | A>G | No | EVA | |
| rs464396044 | 35 | A>S | No | EVA | |
| rs432427761 | 35 | A>V | No | EVA | |
| rs441212525 | 36 | P>R | No | EVA | |
| rs472550265 | 36 | P>S | No | EVA | |
| rs472550265 | 36 | P>T | No | EVA | |
| rs475343950 | 37 | N>D | No | EVA | |
| rs475343950 | 37 | N>H | No | EVA | |
| rs475343950 | 37 | N>Y | No | EVA | |
| rs463775117 | 38 | V>A | No | EVA | |
| rs463775117 | 38 | V>G | No | EVA | |
| rs443937978 | 38 | V>L | No | EVA | |
| rs459466444 | 39 | L>F | No | EVA | |
| rs477437793 | 39 | L>V | No | EVA | |
| rs439236244 | 39 | L>W | No | EVA | |
| rs448069741 | 40 | L>R | No | EVA | |
| rs479415447 | 40 | L>V | No | EVA | |
| rs482156628 | 41 | V>G | No | EVA | |
| rs464332324 | 42 | V>G | No | EVA | |
| rs450851623 | 42 | V>L | No | EVA | |
| rs446125969 | 43 | S>G | No | EVA | |
| rs466293314 | 43 | S>R | No | EVA | |
| rs454915238 | 44 | D>A | No | EVA | |
| rs475043684 | 44 | D>E | No | EVA | |
| rs454915238 | 44 | D>G | No | EVA | |
| rs434730798 | 44 | D>N | No | EVA | |
| rs454915238 | 44 | D>V | No | EVA | |
| rs437435925 | 45 | S>F | No | EVA | |
| rs457498866 | 46 | F>L | No | EVA | |
| rs469032511 | 65 | N>S | No | EVA | |
| rs478210031 | 74 | F>L | No | EVA | |
| rs432864199 | 88 | R>S | No | EVA | |
| rs449590548 | 93 | S>R | No | EVA | |
| rs469650292 | 136 | T>S | No | EVA | |
| rs715940958 | 142 | I>T | No | EVA | |
| rs521415877 | 161 | G>S | No | EVA | |
| rs471430094 | 232 | R>L | No | EVA | |
| rs433844311 | 233 | Y>N | No | EVA | |
| rs454015088 | 234 | W>G | No | EVA | |
| rs481094730 | 241 | D>E | No | EVA | |
| rs443475050 | 243 | I>N | No | EVA | |
| rs461404841 | 244 | K>T | No | EVA | |
| rs463626400 | 247 | K>M | No | EVA | |
| rs483179649 | 278 | N>S | No | EVA | |
| rs466303411 | 332 | S>R | No | EVA | |
| rs1116200399 | 370 | D>N | No | EVA | |
| rs455764595 | 371 | I>F | No | EVA | |
| rs469329284 | 371 | I>S | No | EVA | |
| rs438003361 | 372 | A>S | No | EVA | |
| rs472074534 | 377 | P>H | No | EVA | |
| rs454284321 | 378 | Q>P | No | EVA | |
| rs442457933 | 379 | N>T | No | EVA | |
| rs438533933 | 387 | P>Q | No | EVA | |
| rs462617879 | 390 | S>P | No | EVA | |
| rs458402758 | 402 | L>Q | No | EVA | |
| rs438342069 | 402 | L>V | No | EVA | |
| rs447505632 | 403 | H>L | No | EVA | |
| rs467548759 | 415 | N>I | No | EVA | |
| rs481280592 | 416 | V>E | No | EVA | |
| rs449915286 | 417 | N>K | No | EVA | |
| rs469467315 | 418 | A>G | No | EVA | |
| rs474640671 | 449 | D>H | No | EVA | |
| rs443507893 | 452 | E>G | No | EVA | |
| rs463658164 | 458 | A>E | No | EVA | |
| rs463658164 | 458 | A>V | No | EVA | |
| rs470920624 | 459 | K>R | No | EVA | |
| rs470920624 | 459 | K>T | No | EVA | |
| rs439409326 | 465 | S>P | No | EVA | |
| rs135115477 | 466 | S>L | No | EVA | |
| rs459573988 | 483 | S>C | No | EVA | |
| rs447768830 | 484 | V>A | No | EVA | |
| rs461264279 | 486 | Q>H | No | EVA | |
| rs481467007 | 487 | Y>H | No | EVA | |
| rs450041520 | 489 | K>N | No | EVA | |
| rs477541954 | 498 | S>R | No | EVA | |
| rs446183612 | 501 | Q>K | No | EVA | |
| rs132802159 | 505 | N>T | No | EVA | |
| rs434447445 | 515 | D>A | No | EVA | |
| rs462939417 | 516 | W>C | No | EVA | |
| rs454624156 | 521 | K>M | No | EVA | |
| rs456959441 | 523 | Y>C | No | EVA | |
| rs436788869 | 523 | Y>H | No | EVA | |
| rs436788869 | 523 | Y>N | No | EVA | |
| rs456959441 | 523 | Y>S | No | EVA | |
| rs470859053 | 525 | N>H | No | EVA | |
| rs439550958 | 526 | A>S | No | EVA | |
| rs452991951 | 527 | I>L | No | EVA | |
| rs473238547 | 527 | I>T | No | EVA | |
| rs441242471 | 528 | D>G | No | EVA | |
| rs461449335 | 529 | Q>* | No | EVA | |
| rs481363185 | 529 | Q>P | No | EVA | |
| rs443572416 | 530 | W>R | No | EVA | |
| rs463615634 | 531 | L>F | No | EVA | |
| rs463615634 | 531 | L>V | No | EVA | |
| rs477478881 | 534 | H>P | No | EVA | |
| rs446341740 | 535 | S>P | No | EVA | |
| rs466286370 | 536 | D>A | No | EVA | |
| rs480055406 | 539 | T>K | No | EVA | |
| rs448632025 | 540 | I>N | No | EVA | |
| rs521897566 | 541 | I>= | No | EVA | |
| rs797393958 | 541 | I>W | No | EVA | |
| rs134061992 | 541 | I>W | No | EVA |
No associated diseases with Q148F3
4 regional properties for Q148F3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Intron-binding protein aquarius, N-terminal | 20 - 802 | IPR032174 |
| domain | DNA2/NAM7 helicase, helicase domain | 802 - 1110 | IPR041677 |
| domain | DNA2/NAM7 helicase-like, C-terminal | 1119 - 1309 | IPR041679 |
| domain | Upf1-like, C-terminal helicase domain | 1144 - 1327 | IPR047187 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.6.18 | Sulfuric ester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| arylsulfatase activity | Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. |
| glucuronate-2-sulfatase activity | Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate. |
| metal ion binding | Binding to a metal ion. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8K007 | Sulf1 | Extracellular sulfatase Sulf-1 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLLLWVSVVA | ASALAAPAPG | ADGQRRGAIQ | AWPDAPNVLL | VVSDSFDGRL | TFYPGSQVVK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LPFINFMKAH | GTSFLNAYTN | SPICCPSRAA | MWSGLFTHLT | ESWNNFKGLD | PNYTTWMDVM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EKHGYRTQKF | GKLDYTSGHH | SISNRVEAWT | RDVAFLLRQE | GRPMVNLAPK | KTKVRVMQVD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| WKNTDRAVNW | LRKEASNSTQ | PFVLYLGLNL | PHPYPSPSSG | ENFGSSTFHT | SRYWLKKVSY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DAIKIPKWSP | LSEMHPVDYY | SSYTKNCTGK | FTEKEIKNIR | AFYYAMCAET | DAMLGEIILA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LRQLGLLQKT | IVIYTSDHGE | LAMEHRQFYK | MSMYEASSHV | PLLIMGPGIQ | ANLQVSSVVS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LVDIYPTMLD | IAGIPLPQNL | SGYSLLPSSS | EMFKNEQKFK | NLHPPWILSE | FHGCNVNAST |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YMLRTNQWKY | IAYSDGASVL | PQLFDLSSDP | DELTNIAAKF | PEVTSSLDQK | LRSIINYPKV |
| 490 | 500 | 510 | 520 | 530 | |
| SASVHQYNKE | QFIKWKQSIG | QNYSNVIANL | RWHQDWLKKP | KKYENAIDQW | LKSHSDAKTI |