AiPD: Autoinhibited Protein Database

Q8IZ16

Gene name	SPACDR
Protein name	Sperm acrosome developmental regulator
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:402573
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

4-206 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

4-206 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8IZ16

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8IZ16-F1	Predicted				AlphaFoldDB

164 variants for Q8IZ16

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA163258420 rs749751067	2	V>A		No	ClinGen Ensembl
CA4382303 rs747019846	2	V>I		No	ClinGen ExAC gnomAD
rs1324411786 CA368509461	3	V>A		No	ClinGen gnomAD
CA368509471 rs1379765982	3	V>M		No	ClinGen gnomAD
CA4382301 rs369577590	7	F>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs745459414 CA4382300	9	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA4382299 rs778552272	9	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1182630257 CA368509330	10	W>*		No	ClinGen gnomAD
rs1363368898 CA368509338	10	W>R		No	ClinGen gnomAD
rs377560034 CA4382298	11	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs764569240 CA4382295	13	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA4382296 rs200606904	13	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA368509273 rs956566535	14	A>P		No	ClinGen gnomAD
CA163258379 rs956566535	14	A>T		No	ClinGen gnomAD
rs200926910 CA4382293	15	W>*		No	ClinGen 1000Genomes ExAC gnomAD
CA4382292 rs767633973	15	W>C		No	ClinGen ExAC gnomAD
rs200926910 CA4382294	15	W>L		No	ClinGen 1000Genomes ExAC gnomAD
CA163258368 rs1032201455	16	Q>R		No	ClinGen Ensembl
CA368509206 rs759699614	19	I>F		No	ClinGen ExAC gnomAD
rs759699614 CA4382291	19	I>L		No	ClinGen ExAC gnomAD
CA368509064 rs1584343433	22	V>G		No	ClinGen Ensembl
CA163258084 rs372603779	22	V>I		No	ClinGen ESP
CA163258070 rs780582504	25	W>G		No	ClinGen gnomAD
rs529293605 CA163258068	26	R>K		No	ClinGen 1000Genomes
CA368508980 rs1222674152	26	R>S		No	ClinGen TOPMed gnomAD
CA4382255 rs561894415	28	K>E		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	33	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1282357518 CA368508849	33	I>V		No	ClinGen TOPMed gnomAD
rs540737177 CA4382253	36	H>Q		No	ClinGen 1000Genomes ExAC
rs368343826 CA4382254	36	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA368508738 rs1456385886	40	K>Q		No	ClinGen TOPMed
CA368508704 rs758510212	42	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA4382250 rs750555272	48	E>Q		No	ClinGen ExAC
CA4382248 rs375079598	50	T>I		No	ClinGen ESP ExAC gnomAD
CA4382249 rs765520754	50	T>S		No	ClinGen ExAC gnomAD
CA163258022 rs987874061	53	V>M		No	ClinGen Ensembl
CA368508504 rs1433724656	54	V>D		No	ClinGen TOPMed
CA4382245 rs759464218	55	E>D		No	ClinGen ExAC gnomAD
CA163258018 rs1030178606	55	E>G		No	ClinGen TOPMed gnomAD
rs767357615 CA4382246	55	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA163258007 rs774272096	58	R>G		No	ClinGen ExAC gnomAD
CA4382244 rs774272096	58	R>W		No	ClinGen ExAC gnomAD
CA163258005 rs1032168870	60	V>G		No	ClinGen TOPMed gnomAD
rs1161037339 CA368508449	60	V>I		No	ClinGen TOPMed gnomAD
CA4382241 rs772697296 COSM1082855	61	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1453371760 CA368508414	64	K>Q		No	ClinGen TOPMed
CA163257957 rs979240956	65	E>G		No	ClinGen Ensembl
CA4382240 rs769460121	66	A>V		No	ClinGen ExAC gnomAD
CA4382239 rs747854244	67	K>E		No	ClinGen ExAC gnomAD
CA368508367 rs1216127732	69	K>Q		No	ClinGen TOPMed gnomAD
rs573227635 CA4382238	71	G>D		No	ClinGen 1000Genomes ExAC gnomAD
rs1246045356 CA368508338	72	E>*		No	ClinGen TOPMed
rs769213869 CA4382237	73	S>Y		No	ClinGen ExAC gnomAD
CA368508313 rs1232077425	74	P>R		No	ClinGen gnomAD
CA4382235 rs368528299	75	E>K		No	ClinGen ESP ExAC TOPMed
rs750549956 CA4382232	78	D>H		No	ClinGen ExAC gnomAD
rs750549956 CA368508281	78	D>N		No	ClinGen ExAC gnomAD
CA368508263 rs373829724	80	C>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA4382231 rs778906854	80	C>G		No	ClinGen ExAC gnomAD
rs370137741 CA4382229 CA4382227	81	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs370137741 CA4382228	81	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA4382225 rs368158174	82	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs868566225 CA163257825 COSM243407	83	A>T	prostate [Cosmic]	No	ClinGen cosmic curated Ensembl
rs1310548728 CA368508238	85	T>A		No	ClinGen gnomAD
CA4382224 rs373944182	88	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA368508217 rs1433498181	88	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA4382223 rs575572416	89	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA368508208 rs575572416	89	T>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA368508205 rs1417789451	90	E>K		No	ClinGen gnomAD
rs1193282884 CA368508199	91	V>M		No	ClinGen gnomAD
rs370601799 CA4382221	92	E>G		No	ClinGen ESP ExAC TOPMed
rs1584343311 CA368508182	93	L>R		No	ClinGen Ensembl
CA4382220 rs557226210	94	G>R		No	ClinGen 1000Genomes ExAC gnomAD
rs376745201 CA4382219	95	Q>R		No	ClinGen ESP ExAC gnomAD
rs1212113156 CA368508162	96	Q>H		No	ClinGen gnomAD
rs1482938735 CA368508169	96	Q>K		No	ClinGen gnomAD
rs1256546099 CA368508164	96	Q>P		No	ClinGen gnomAD
rs1584343289 CA368508125	102	Q>H		No	ClinGen Ensembl
rs1277328174 CA368508114	104	P>L		No	ClinGen TOPMed gnomAD
COSM3662783 rs374075414 CA4382218	106	T>M	liver [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1207244140 CA368508100	107	A>T		No	ClinGen TOPMed
CA4382215 rs371314399	108	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA163257731 rs1054619347	111	V>F		No	ClinGen TOPMed gnomAD
CA4382213 rs749450569	113	T>K		No	ClinGen ExAC TOPMed gnomAD
CA4382212 rs749450569	113	T>M		No	ClinGen ExAC TOPMed gnomAD
CA368508043 rs1478318703	116	V>F		No	ClinGen gnomAD
CA4382209 rs201441021	119	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs766139269 CA4382208	120	Q>R		No	ClinGen ExAC gnomAD
rs1563177145 CA368508014	121	S>C		No	ClinGen Ensembl
rs761422184 CA4382205	122	G>C		No	ClinGen ExAC gnomAD
CA4382204 rs761422184	122	G>S		No	ClinGen ExAC gnomAD
rs1257282067 CA368507985	125	M>L		No	ClinGen TOPMed gnomAD
CA368507986 rs1257282067	125	M>V		No	ClinGen TOPMed gnomAD
CA368507973 rs1342423790	126	C>Y		No	ClinGen TOPMed
rs1199063983 CA368507965	127	S>I		No	ClinGen gnomAD
TCGA novel	128	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4382182 rs752295442	130	S>L		No	ClinGen ExAC TOPMed gnomAD
rs759835818 CA4382180	131	S>L		No	ClinGen ExAC TOPMed gnomAD
rs767865736 CA4382181	131	S>T		No	ClinGen ExAC gnomAD
CA4382178 rs771393786	135	A>T		No	ClinGen ExAC TOPMed gnomAD
CA4382177 rs763497473	138	S>R		No	ClinGen ExAC
CA368506767 rs1441464118	142	R>S		No	ClinGen gnomAD
CA4382175 rs200188453	143	T>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs199608159 CA4382174	143	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1269057777 CA368506754	144	Q>*		No	ClinGen gnomAD
CA368506757 rs1269057777	144	Q>K		No	ClinGen gnomAD
CA368506752 rs1457206275	144	Q>P		No	ClinGen TOPMed
TCGA novel CA163253380 rs904721701	148	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen TOPMed NCI-TCGA
CA368506680 rs778893410	150	P>L		No	ClinGen ExAC TOPMed
CA4382169 rs778893410	150	P>Q		No	ClinGen ExAC TOPMed
rs753891923 CA4382167	151	E>G		No	ClinGen ExAC gnomAD
rs777350780 CA368506663	152	A>P		No	ClinGen ExAC TOPMed gnomAD
rs777350780 CA4382166	152	A>T		No	ClinGen ExAC TOPMed gnomAD
CA4382164 rs752344902	160	L>Q		No	ClinGen ExAC TOPMed gnomAD
CA163253344 rs752344902	160	L>R		No	ClinGen ExAC TOPMed gnomAD
rs759269118 CA4382162	161	V>A		No	ClinGen ExAC gnomAD
rs767103499 CA4382163	161	V>M		No	ClinGen ExAC gnomAD
COSM451969 CA4382160 rs201441317	165	V>I	breast [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs375194900 CA4382158	166	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs763448516 CA4382159	166	R>W		No	ClinGen ExAC gnomAD
rs556655296 CA4382157	167	K>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4382156 rs761825846	169	L>V		No	ClinGen ExAC gnomAD
rs368741513 CA4382154	170	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA368506422 rs1202358762	170	R>H		No	ClinGen TOPMed
CA4382153 rs768730896	171	R>Q		No	ClinGen ExAC TOPMed
rs1477288122 CA368506413	171	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs908269258 CA163253237	173	Y>C		No	ClinGen TOPMed gnomAD
rs1216048789 CA368506365	174	R>C		No	ClinGen gnomAD
CA4382152 rs200982704	174	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs371904128 CA4382151	175	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA368506348 rs1277172611	175	R>S		No	ClinGen gnomAD
CA368506336 rs1162868880	176	Q>R		No	ClinGen TOPMed
CA4382149 rs770853529	180	R>I		No	ClinGen ExAC gnomAD
CA368506265 rs749177909	181	R>G		No	ClinGen ExAC TOPMed gnomAD
CA4382147 rs755606051	181	R>L		No	ClinGen ExAC TOPMed gnomAD
CA4382146 rs755606051	181	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA4382148 rs749177909	181	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1306207807 CA368506230	183	H>Y		No	ClinGen TOPMed
rs754571274 CA4382143	184	V>I		No	ClinGen ExAC TOPMed gnomAD
CA4382141 rs535561832	185	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs535561832 CA163253200	185	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA4382140 rs758779280	185	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA4382139 rs778401953	187	H>R		No	ClinGen ExAC TOPMed gnomAD
CA368506135 rs1168278211	189	A>V		No	ClinGen gnomAD
rs762423745 CA4382138	191	R>*		No	ClinGen ExAC TOPMed gnomAD
rs762423745 CA4382137	191	R>G		No	ClinGen ExAC TOPMed gnomAD
CA4382136 rs776552865	191	R>Q		No	ClinGen ExAC TOPMed
CA4382134 rs764293732	192	P>L		No	ClinGen ExAC TOPMed gnomAD
rs764293732 CA368506104	192	P>R		No	ClinGen ExAC TOPMed gnomAD
CA4382133 rs760740032	193	N>Y		No	ClinGen ExAC TOPMed gnomAD
rs775867552 CA4382132	194	P>L		No	ClinGen ExAC gnomAD
rs775867552 CA368506069	194	P>R		No	ClinGen ExAC gnomAD
CA368506072 rs1187549038	194	P>S		No	ClinGen gnomAD
CA4382130 rs568044482	195	A>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA368506030 rs773176935	197	S>C		No	ClinGen ExAC TOPMed gnomAD
CA4382129 rs773176935	197	S>F		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	198	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA368505970 rs1377141658	202	A>T		No	ClinGen gnomAD
rs1448763401 CA368505920	205	P>A		No	ClinGen gnomAD
TCGA novel	206	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA4382126 rs780561496	206	L>P		No	ClinGen ExAC TOPMed gnomAD
CA4382125 rs754523352	207	L>K		No	ClinGen ExAC gnomAD
rs1445829033 CA576712997	207	L>W		No	ClinGen gnomAD
rs1395591321 CA368505889	207	L>Y		No	ClinGen gnomAD

1 associated diseases with Q8IZ16

Without disease ID

No regional properties for Q8IZ16

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q8IZ16

Functions

		Description
EC Number
Subcellular Localization	Cytoplasmic vesicle, secretory vesicle, acrosome	Detected in acrosome of round spermatids and spermatozoa
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
acrosomal vesicle	A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name	Definition
spermatid development	The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q2T9X5	SPACDR	Sperm acrosome developmental regulator	Bos taurus (Bovine)	PR
Q6AY52	Spacdr	Sperm acrosome developmental regulator	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MVVVMKFFRW	VRRAWQRIIS	WVFFWRQKIK	PTISGHPDSK	KHSLKKMEKT	LQVVETLRLV
70	80	90	100	110	120
ELPKEAKPKL	GESPELADPC	VLAKTTEETE	VELGQQGQSL	LQLPRTAVKS	VSTLMVSALQ
130	140	150	160	170	180
SGWQMCSWKS	SVSSASVSSQ	VRTQSPLKTP	EAELLWEVYL	VLWAVRKHLR	RLYRRQERHR
190	200
RHHVRCHAAP	RPNPAQSLKL	DAQSPL