AiPD: Autoinhibited Protein Database

Q8IUF1

Gene name	ZNG1B
Protein name	Zinc-regulated GTPase metalloprotein activator 1B
Names	Cobalamin synthase W domain-containing protein 2, COBW domain-containing protein 2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:150472
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-65 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q8IUF1

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8IUF1-F1	Predicted				AlphaFoldDB

280 variants for Q8IUF1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs140753748 CA1840550	3	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA1840551 rs756664315	3	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1436900255 CA348310842	4	A>T		No	ClinGen TOPMed gnomAD
TCGA novel CA348310855 rs1470662071	6	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen gnomAD
CA1840554 rs2475446	8	A>V		No	ClinGen ExAC TOPMed gnomAD
CA348310883 rs1302070121	9	D>E		No	ClinGen TOPMed
CA348310880 rs746718702	9	D>G		No	ClinGen ExAC TOPMed gnomAD
rs746718702 CA1840556	9	D>V		No	ClinGen ExAC TOPMed gnomAD
CA1840555 rs779692251	9	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs768154666 CA1840558	10	E>K		No	ClinGen ExAC TOPMed gnomAD
CA1840561 rs145583603	12	E>K		No	ClinGen ESP ExAC gnomAD
rs145583603 CA348310922	12	E>Q		No	ClinGen ESP ExAC gnomAD
rs1278593349 CA348310957	14	P>A		No	ClinGen TOPMed gnomAD
rs1278593349 CA348310959	14	P>S		No	ClinGen TOPMed gnomAD
rs1284320656 CA348310988	16	E>G		No	ClinGen gnomAD
CA348310984 rs1225797515	16	E>K		No	ClinGen gnomAD
rs769728276 CA348311024	18	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1323495602 CA348311021	18	D>V		No	ClinGen gnomAD
rs773198947 CA1840563	19	C>F		No	ClinGen ExAC TOPMed gnomAD
CA1840564 rs762863119	21	E>*		No	ClinGen ExAC gnomAD
CA348311046 rs1266875176	21	E>D		No	ClinGen TOPMed
CA348311054 rs1203840504	22	L>F		No	ClinGen gnomAD
rs374912448 CA53728487	23	V>F		No	ClinGen ESP gnomAD
rs1490901879 CA348311067	25	M>V		No	ClinGen gnomAD
rs771048315 CA1840565	26	E>G		No	ClinGen ExAC gnomAD
CA1840566 rs774263231	27	T>M		No	ClinGen ExAC TOPMed gnomAD
CA1840567 rs759830894	28	T>M		No	ClinGen ExAC gnomAD
CA1840568 rs767581923	29	Q>L		No	ClinGen ExAC TOPMed gnomAD
CA348311109 rs1410052837	31	E>K		No	ClinGen gnomAD
CA1840572 rs754448906	35	K>R		No	ClinGen ExAC gnomAD
rs757811718 CA1840573	37	G>D		No	ClinGen ExAC gnomAD
rs373120143 CA1840574	38	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs754672635 CA348311224	39	G>C		No	ClinGen ExAC TOPMed gnomAD
rs754672635 CA1840576	39	G>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	41	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1296158076 CA348311295	44	V>A		No	ClinGen TOPMed
TCGA novel	45	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	46	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1354323632 CA348311337	47	I>M		No	ClinGen TOPMed
CA348311328 rs1268402378	47	I>V		No	ClinGen gnomAD
CA1840580 rs777521352	48	T>N		No	ClinGen ExAC TOPMed gnomAD
CA348311354 rs1243832215	49	G>V		No	ClinGen gnomAD
rs1481992717 CA348311633	52	G>D		No	ClinGen TOPMed gnomAD
TCGA novel	54	G>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348311659 rs1387682477	56	T>K		No	ClinGen gnomAD
rs1196973720 CA348311668	57	T>I		No	ClinGen gnomAD
rs199530319 CA53729834	60	N>K		No	ClinGen TOPMed gnomAD
rs1291596502 CA348311683	60	N>T		No	ClinGen TOPMed
CA348311691 rs1325192415	61	Y>C		No	ClinGen TOPMed gnomAD
rs1325192415 CA348311690	61	Y>S		No	ClinGen TOPMed gnomAD
rs762202506 CA1840610	62	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1553436092 CA348311709	64	T>A		No	ClinGen Ensembl
CA53729839 rs535124182	66	Q>*		No	ClinGen 1000Genomes
rs1461045215 CA348311738	68	S>G		No	ClinGen TOPMed
CA348311753 rs1573673581	70	R>G		No	ClinGen Ensembl
CA348311760 rs1480939783	71	V>I		No	ClinGen TOPMed gnomAD
CA348311761 rs1480939783	71	V>L		No	ClinGen TOPMed gnomAD
rs1573673618 CA348311767	72	A>P		No	ClinGen Ensembl
rs1176009571 CA348311769	72	A>V		No	ClinGen TOPMed gnomAD
rs1318165971 CA348311796	76	N>S		No	ClinGen TOPMed gnomAD
rs1553436114 CA348311811	78	F>Y		No	ClinGen Ensembl
CA348311816 rs1451240291	79	G>W		No	ClinGen TOPMed
rs907259389 CA53729848	80	E>G		No	ClinGen TOPMed
rs1225457716 CA348311844	81	G>E		No	ClinGen TOPMed gnomAD
CA348311846 rs1225457716	81	G>V		No	ClinGen TOPMed gnomAD
CA1840627 rs200825474	82	S>R		No	ClinGen ExAC TOPMed gnomAD
CA348311858 rs988621436	83	A>G		No	ClinGen TOPMed gnomAD
CA53730738 rs988621436	83	A>V		No	ClinGen TOPMed gnomAD
CA53730744 rs914410924	84	L>M		No	ClinGen TOPMed
CA348311884 rs1221377427	87	S>F		No	ClinGen gnomAD
rs1487027669 CA348311895	89	A>G		No	ClinGen gnomAD
CA348311916 rs1189814055	92	Q>R		No	ClinGen gnomAD
rs1240919241 CA348311925	93	G>V		No	ClinGen TOPMed
rs1447746658 CA348311926	94	G>R		No	ClinGen gnomAD
CA348311940 rs1314321335	96	L>V		No	ClinGen TOPMed
CA348311949 rs1185484020	97	Y>C		No	ClinGen TOPMed gnomAD
CA348311951 rs1185484020	97	Y>S		No	ClinGen TOPMed gnomAD
CA348311954 rs1386173166	98	E>K		No	ClinGen gnomAD
CA348311962 rs1384323371	99	E>K		No	ClinGen TOPMed
rs1224710382 CA348311988	102	E>G		No	ClinGen Ensembl
rs1423435484 CA348311984	102	E>K		No	ClinGen gnomAD
rs1158343310 CA348312000	104	R>K		No	ClinGen TOPMed gnomAD
rs201389016 CA53730760	106	G>S		No	ClinGen TOPMed gnomAD
CA348312025 rs1573680811	107	C>W		No	ClinGen Ensembl
CA348312030 rs1573680829	108	L>P		No	ClinGen Ensembl
CA348312036 rs1385229395	109	C>F		No	ClinGen TOPMed
CA348312033 rs1573680843	109	C>R		No	ClinGen Ensembl
CA348312037 rs1385229395	109	C>Y		No	ClinGen TOPMed
rs200145218 CA1840628	110	C>Y		No	ClinGen ExAC TOPMed gnomAD
CA535244752 rs1340545541	111	S>*		No	ClinGen gnomAD
rs1573680946 CA348312061	113	K>*		No	ClinGen Ensembl
CA1840636 rs774990656	115	N>S		No	ClinGen ExAC TOPMed gnomAD
CA348312094 rs1411234538	116	G>S		No	ClinGen gnomAD
CA348312118 rs1338572643	119	A>T		No	ClinGen TOPMed gnomAD
CA1840639 rs753543790	120	I>T		No	ClinGen ExAC gnomAD
rs763586852 CA1840638	120	I>V		No	ClinGen ExAC TOPMed gnomAD
rs944611365 CA53731063	123	L>S		No	ClinGen Ensembl
CA1840640 rs761498305	125	Q>R		No	ClinGen ExAC gnomAD
TCGA novel	126	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1279176326 CA348312268	128	G>R		No	ClinGen TOPMed
rs764974768 CA1840641	130	F>Y		No	ClinGen ExAC TOPMed gnomAD
rs765855293 CA1840642	131	D>G		No	ClinGen ExAC gnomAD
rs1558899912 CA348312319	131	D>Y		No	ClinGen Ensembl
CA348312345 rs1286617278	132	Y>D		No	ClinGen TOPMed gnomAD
CA348312405 rs1303046191	135	L>*		No	ClinGen TOPMed
CA348312434 rs1558900017	137	T>N		No	ClinGen Ensembl
rs143982835 CA1840643	137	T>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs780070293 CA1840644	138	T>S		No	ClinGen ExAC gnomAD
CA1840645 rs751538696	139	G>A		No	ClinGen ExAC gnomAD
CA1840646 rs751538696	139	G>E		No	ClinGen ExAC gnomAD
CA1840647 rs781401313	140	L>F		No	ClinGen ExAC gnomAD
CA348312511 rs1483501684	142	D>E		No	ClinGen gnomAD
CA1840648 rs748357002	142	D>H		No	ClinGen ExAC TOPMed gnomAD
rs748357002 CA348312499	142	D>N		No	ClinGen ExAC TOPMed gnomAD
rs770017121 CA1840649	143	P>L		No	ClinGen ExAC gnomAD
CA348312515 rs1182680823	143	P>S	Variant assessed as Somatic; 4.622e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA348313660 rs749463741	144	G>A		No	ClinGen ExAC TOPMed gnomAD
CA1840673 rs749463741	144	G>V		No	ClinGen ExAC TOPMed gnomAD
CA348313674 rs1331828653	146	V>M		No	ClinGen TOPMed gnomAD
rs771340569 CA1840677	148	S>F		No	ClinGen ExAC gnomAD
rs772522960 CA1840680	149	M>I		No	ClinGen ExAC gnomAD
rs779225253 CA1840678	149	M>L		No	ClinGen ExAC gnomAD
rs779225253 CA1840679	149	M>V		No	ClinGen ExAC gnomAD
CA348313752 rs1402401836	151	W>*		No	ClinGen TOPMed
rs776135902 CA1840681	151	W>L		No	ClinGen ExAC gnomAD
rs1173560285 CA348313762	152	V>A		No	ClinGen TOPMed
rs1173560285 CA348313761	152	V>D		No	ClinGen TOPMed
TCGA novel	153	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1341010206 CA348313767	153	D>G		No	ClinGen TOPMed gnomAD
CA1840682 rs761324630	153	D>N		No	ClinGen ExAC gnomAD
rs1341010206 CA348313768	153	D>V		No	ClinGen TOPMed gnomAD
rs769182972 CA1840683	154	A>T		No	ClinGen ExAC TOPMed gnomAD
CA1840684 rs772977285	157	G>E		No	ClinGen ExAC gnomAD
CA1840707 rs748976990	164	G>D		No	ClinGen ExAC gnomAD
rs1451423699 CA348313842	164	G>S		No	ClinGen TOPMed gnomAD
rs748976990 CA348313856	164	G>V		No	ClinGen ExAC gnomAD
CA348313858 rs1163797532	165	I>V		No	ClinGen gnomAD
rs1415631039 CA348313864	166	I>L		No	ClinGen gnomAD
TCGA novel	166	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1458725391 CA348313876	167	T>I		No	ClinGen gnomAD
TCGA novel	167	T>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1840708 rs559773200	168	I>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs559773200 CA1840709	168	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA348313900 rs1219010322	171	S>*		No	ClinGen TOPMed
rs1427959168 CA348313903	172	K>E		No	ClinGen gnomAD
rs767415398 CA1840711	174	G>R		No	ClinGen ExAC gnomAD
rs775555744 CA1840712	175	L>F		No	ClinGen ExAC TOPMed
rs760686794 CA1840737	179	A>G		No	ClinGen ExAC gnomAD
rs2785346 CA53737107	179	A>T		No	ClinGen Ensembl
rs200424294 CA53737122	180	E>K		No	ClinGen TOPMed gnomAD
rs1268572226 CA348314484	181	E>K		No	ClinGen TOPMed gnomAD
rs1268572226 CA348314486	181	E>Q		No	ClinGen TOPMed gnomAD
CA1840738 rs768420618	182	K>N		No	ClinGen ExAC gnomAD
CA348314538 rs1407405317	187	I>V		No	ClinGen TOPMed
CA1840741 rs542958391	188	N>S		No	ClinGen 1000Genomes ExAC gnomAD
rs750696528 CA1840742	192	R>M		No	ClinGen ExAC TOPMed gnomAD
rs761720756 CA1840758	193	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA1840759 rs769905818	194	V>F		No	ClinGen ExAC gnomAD
rs1184992164 CA348314717	199	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs3203717 CA53738127	199	A>V		No	ClinGen gnomAD
rs376064146 CA1840761	202	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs766451868 CA1840762	203	N>S		No	ClinGen ExAC gnomAD
CA53738164 rs768422582	203	N>Y		No	ClinGen Ensembl
CA348314801 rs1415274871	205	T>A		No	ClinGen gnomAD
CA348314806 rs751954865	205	T>I		No	ClinGen ExAC gnomAD
CA1840763 rs751954865	205	T>K		No	ClinGen ExAC gnomAD
rs759880703 CA1840764	208	V>F		No	ClinGen ExAC gnomAD
rs759880703 CA348314839	208	V>I		No	ClinGen ExAC gnomAD
rs939006970 CA53738187	210	E>Q		No	ClinGen TOPMed
TCGA novel	211	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA1840767 rs767906734	214	K>E		No	ClinGen ExAC TOPMed gnomAD
CA348314918 rs1346456603 COSM1005703	214	K>N	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA1840768 rs144687267	214	K>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs778595036 CA1840770	217	R>I		No	ClinGen ExAC gnomAD
rs886802765 CA53738212	217	R>S		No	ClinGen TOPMed
CA348314956 rs144103320	218	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA53738215 rs71416525	218	A>T		No	ClinGen Ensembl
CA1840771 rs144103320	218	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs779641221 CA1840773	219	T>A		No	ClinGen ExAC gnomAD
rs1416222543 CA348315147	221	R>S		No	ClinGen TOPMed gnomAD
rs927505767 CA53739255	222	S>P		No	ClinGen TOPMed gnomAD
CA348315156 rs1354155615	223	I>T		No	ClinGen gnomAD
rs530131254 CA53739256	223	I>V		No	ClinGen 1000Genomes
rs1421652251 CA348315165	224	N>K		No	ClinGen TOPMed
CA53739257 rs938931462	228	Q>R		No	ClinGen TOPMed
CA348315208 rs1573735904	231	E>A		No	ClinGen Ensembl
rs1375025492 CA348315223	233	Q>R		No	ClinGen TOPMed
CA348315241 rs1196431855	236	R>*		No	ClinGen TOPMed
CA348315244 rs1453576394	236	R>T		No	ClinGen TOPMed
rs562310973 CA1840794	237	V>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1261282878 CA348315270	238	D>A		No	ClinGen TOPMed gnomAD
CA348315271 rs1261282878	238	D>V		No	ClinGen TOPMed gnomAD
CA1840795 rs371712727	239	L>P		No	ClinGen ExAC TOPMed gnomAD
rs749231554 CA1840797	240	S>C		No	ClinGen ExAC TOPMed gnomAD
rs13339786 CA1840798	242	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA348315302 rs1164085221	243	L>*		No	ClinGen gnomAD
CA348315309 rs1391651972	244	D>G		No	ClinGen gnomAD
rs1436569405 CA348315315	245	L>V		No	ClinGen gnomAD
CA1840799 rs199832921	247	A>T		No	ClinGen ExAC TOPMed gnomAD
CA1840800 rs746107134	247	A>V		No	ClinGen ExAC gnomAD
rs772370167 CA1840801	248	F>S		No	ClinGen ExAC gnomAD
rs761190765 CA1840803	250	S>G		No	ClinGen ExAC gnomAD
CA1840804 rs764540497	250	S>N		No	ClinGen ExAC gnomAD
rs777054336 CA1840805	252	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA348315366 rs1331384000	253	G>E		No	ClinGen TOPMed gnomAD
CA1840806 rs762354322	255	S>C		No	ClinGen ExAC gnomAD
TCGA novel	255	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1260405180 CA348315379	255	S>T		No	ClinGen gnomAD
CA348316471 rs1212522730	258	K>N		No	ClinGen TOPMed gnomAD
CA53748254 rs1021672693	258	K>R		No	ClinGen TOPMed gnomAD
rs1426195215 CA348316515	262	H>L		No	ClinGen TOPMed
rs1426195215 CA348316513	262	H>P		No	ClinGen TOPMed
rs1281229210 CA348316517	262	H>Q		No	ClinGen gnomAD
TCGA novel	262	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1387883225 CA348316525	263	V>A		No	ClinGen TOPMed
rs879513104 CA53748264	264	P>S		No	ClinGen TOPMed gnomAD
rs969202273 CA53748275	266	T>A		No	ClinGen TOPMed
rs1209879142 CA348316556	267	Q>P		No	ClinGen gnomAD
rs980220150 CA53748287	268	P>L		No	ClinGen TOPMed gnomAD
CA348316578 rs200305938	269	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA348316593 rs1406646897	271	D>H		No	ClinGen gnomAD
CA53748293 rs937880614	272	Q>E		No	ClinGen TOPMed
CA53750914 rs911737589	273	S>N		No	ClinGen TOPMed
CA348316848 rs1279413381	277	I>N		No	ClinGen gnomAD
CA348316844 rs1443598521	277	I>V		No	ClinGen TOPMed gnomAD
CA348316855 rs1222433757	278	T>I		No	ClinGen TOPMed
CA53750917 rs944596416	280	E>A		No	ClinGen TOPMed gnomAD
CA348316900 rs1221008100	285	A>E		No	ClinGen gnomAD
CA348316922 rs1347392478	288	E>A		No	ClinGen gnomAD
rs1280497502 CA348316934	289	H>Q		No	ClinGen TOPMed
rs1233358376 CA348316946	291	N>I		No	ClinGen gnomAD
CA348316951 rs1277954542	292	M>L		No	ClinGen gnomAD
CA348316953 rs1439299584	292	M>T		No	ClinGen gnomAD
rs1300011002 CA348317014	299	W>G		No	ClinGen gnomAD
rs199843165 CA53750983	303	V>M		No	ClinGen TOPMed gnomAD
CA348317068 rs1354150436	306	K>T		No	ClinGen TOPMed
rs1305669156 CA348317085	308	N>S		No	ClinGen TOPMed gnomAD
rs1415922723 CA348317091	309	H>Y		No	ClinGen TOPMed
CA348317102 rs1285181113	310	C>Y		No	ClinGen TOPMed gnomAD
CA348317120 rs1453382278	312	E>D		No	ClinGen TOPMed
CA348317153 rs1487387075	316	L>P		No	ClinGen TOPMed gnomAD
CA1840834 rs374153631	322	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1359185768 CA348317283	324	D>A		No	ClinGen TOPMed gnomAD
CA348317285 rs1359185768	324	D>G		No	ClinGen TOPMed gnomAD
CA348317393 rs1269399187	333	G>A		No	ClinGen gnomAD
rs757154117 CA1840837	333	G>C		No	ClinGen ExAC TOPMed gnomAD
rs757154117 CA1840836	333	G>R		No	ClinGen ExAC TOPMed gnomAD
CA1840838 rs551366691	335	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA1840840 rs780250768	336	E>G		No	ClinGen ExAC TOPMed gnomAD
rs758600128 CA1840839	336	E>K		No	ClinGen ExAC
CA348317429 rs1385229466	337	L>I		No	ClinGen gnomAD
CA53751289 rs768954597	338	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs768954597 CA1840842	338	Y>S		No	ClinGen ExAC TOPMed gnomAD
CA348317478 rs1211268397	341	E>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs781425560 CA1840843	344	P>S		No	ClinGen ExAC gnomAD
rs1408704386 CA348317523	345	V>L		No	ClinGen TOPMed
rs1342084779 CA348317533	346	S>N		No	ClinGen gnomAD
CA348317578 rs1573810748	349	D>E		No	ClinGen Ensembl
rs748482498 CA1840844	353	R>*		No	ClinGen ExAC TOPMed gnomAD
CA348317622 COSM1005705 rs1354347258	353	R>I	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA348317620 rs1354347258	353	R>K		No	ClinGen TOPMed
rs1451591225 CA348317629	354	T>A		No	ClinGen TOPMed
CA348317636 rs1240752834	354	T>K		No	ClinGen gnomAD
rs770047712 CA1840845	355	N>S		No	ClinGen ExAC gnomAD
CA1840847 rs763423973	356	R>G		No	ClinGen ExAC gnomAD
CA1840848 rs771606644	356	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1459978753 CA348317666	357	L>F		No	ClinGen gnomAD
rs202027283 CA53751349	360	L>I		No	ClinGen Ensembl
TCGA novel	363	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	364	L>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA53751477 rs937665707	371	Q>H		No	ClinGen TOPMed gnomAD
CA53751518 rs113235957	374	I>L		No	ClinGen TOPMed
rs113235957 CA53751483	374	I>V		No	ClinGen TOPMed
rs1157104864 CA348317836	379	E>K		No	ClinGen gnomAD
rs1573811607 CA348317886	385	T>K		No	ClinGen Ensembl
CA53751523 rs939802143	386	T>A		No	ClinGen TOPMed gnomAD
CA348317928 rs1417030969	391	D>N		No	ClinGen TOPMed
TCGA novel	392	Q>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA348317943 rs1553446679	393	V>L		No	ClinGen Ensembl
rs1164874199 CA348317956	395	T>P		No	ClinGen TOPMed

No associated diseases with Q8IUF1

2 regional properties for Q8IUF1

Type	Name	Position	InterPro Accession
domain	CobW/HypB/UreG, nucleotide-binding domain	43 - 230	IPR003495
domain	Zinc chaperone CobW-like, C-terminal	274 - 375	IPR011629

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

2 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P53729	ZNG1	Zinc-regulated GTPase metalloprotein activator 1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q9BRT8	ZNG1A	Zinc-regulated GTPase metalloprotein activator 1A	Homo sapiens (Human)	PR

10	20	30	40	50	60
MLPAVGSADE	EEDPAEEDCP	ELVPMETTQS	EEEEKSGLGA	KIPVTIITGY	LGAGKTTLLN
70	80	90	100	110	120
YILTEQHSKR	VAVILNEFGE	GSALEKSLAV	SQGGELYEEW	LELRNGCLCC	SVKDNGLRAI
130	140	150	160	170	180
ENLMQKKGKF	DYILLETTGL	ADPGAVASMF	WVDAELGSDI	YLDGIITIVD	SKYGLKHLAE
190	200	210	220	230	240
EKPDGLINEA	TRQVALADAI	LINKTDLVPE	EDVKKLRATI	RSINGLGQIL	ETQRSRVDLS
250	260	270	280	290	300
NVLDLHAFDS	LSGISLQKKL	QHVPGTQPHL	DQSIVTITFE	VPGNAKEEHL	NMFIQNLLWE
310	320	330	340	350	360
KNVRNKDNHC	MEVIRLKGLV	SIKDKSQQVI	VQGVHELYDL	EETPVSWKDD	TERTNRLVLL
370	380	390
GRNLDKDILK	QLFIATVTET	EKQWTTHFKE	DQVCT