P53729

PR
Gene name
ZNG1
Protein name
Zinc-regulated GTPase metalloprotein activator 1
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YNR029C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

17-97 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P53729

Entry ID Method Resolution Chain Position Source
AF-P53729-F1 Predicted AlphaFoldDB

14 variants for P53729

Variant ID(s) Position Change Description Diseaes Association Provenance
s14-678324 56 E>G No SGRP
s14-678313 60 A>T No SGRP
s14-678306 62 A>V No SGRP
s14-677905 196 I>V No SGRP
s14-677704 263 V>I No SGRP
s14-677652 280 T>M No SGRP
s14-677611 294 V>I No SGRP
s14-677583 303 G>D No SGRP
s14-677532 320 T>N No SGRP
s14-677452 347 F>L No SGRP
s14-677440 351 T>S No SGRP
s14-677424 356 R>H No SGRP
s14-677269 408 I>V No SGRP
s14-677205 429 E>G No SGRP

No associated diseases with P53729

2 regional properties for P53729

Type Name Position InterPro Accession
domain CobW/HypB/UreG, nucleotide-binding domain 72 - 273 IPR003495
domain Zinc chaperone CobW-like, C-terminal 362 - 427 IPR011629

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
zinc chaperone activity Binding to and delivering zinc ions to a target protein.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9BRT8 ZNG1A Zinc-regulated GTPase metalloprotein activator 1A Homo sapiens (Human) PR
Q8IUF1 ZNG1B Zinc-regulated GTPase metalloprotein activator 1B Homo sapiens (Human) PR
10 20 30 40 50 60
MSALRNIKFN EEEDGELPCL VTGEENNLQE ILENVSYDGG NIVSDAKVER VNKQVENTSA
70 80 90 100 110 120
GATDVHEKKR IPVSIITGYL GSGKSTLLEK IALKGADKKI AVILNEFGDS SEIEKAMTIK
130 140 150 160 170 180
NGSNSYQEWL DLGNGCLCCS LKNIGVKAIE DMVERSPGKI DYILLETSGI ADPAPIAKMF
190 200 210 220 230 240
WQDEGLNSSV YIDGIITVLD CEHILKCLDD ISIDAHWHGD KVGLEGNLTI AHFQLAMADR
250 260 270 280 290 300
IIMNKYDTIE HSPEMVKQLK ERVREINSIA PMFFTKYSDT PIQNLLDIHA YDSVRISDIL
310 320 330 340 350 360
DSGSGNGTIH DDRMGTIMLT FRPLKNEEEY NNKFIKQFLQ PLLWKNFGAM TVLGGRRRDD
370 380 390 400 410 420
GRDWEVQRTK GLILIEGENP IARVIQGVRD TYDVFPGKYD GSNKECKIVL IGKYLEKESI
EELLRKTLE