Q8H0W9
Gene name |
At5g10410 (F12B17_240) |
Protein name |
Putative clathrin assembly protein At5g10410 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G10410 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8H0W9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8H0W9-F1 | Predicted | AlphaFoldDB |
30 variants for Q8H0W9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_5_3271968_C_G | 6 | T>S | No | 1000Genomes | |
| tmp_5_3271972_C_G | 7 | H>Q | No | 1000Genomes | |
| ENSVATH06948083 | 10 | G>R | No | 1000Genomes | |
| ENSVATH03043707 | 26 | S>G | No | 1000Genomes | |
| tmp_5_3272042_G_T | 31 | A>S | No | 1000Genomes | |
| ENSVATH06948085 | 35 | I>F | No | 1000Genomes | |
| tmp_5_3272087_A_C | 46 | T>P | No | 1000Genomes | |
| ENSVATH03043708 | 48 | N>D | No | 1000Genomes | |
| tmp_5_3272127_T_C | 59 | V>A | No | 1000Genomes | |
| ENSVATH10681329 | 66 | R>G | No | 1000Genomes | |
| ENSVATH13981026 | 80 | R>H | No | 1000Genomes | |
| ENSVATH13981028 | 154 | G>R | No | 1000Genomes | |
| tmp_5_3272562_A_G | 166 | K>R | No | 1000Genomes | |
| ENSVATH10681400 | 173 | V>I | No | 1000Genomes | |
| ENSVATH00614847 | 175 | S>T | No | 1000Genomes | |
| ENSVATH00614848 | 178 | T>I | No | 1000Genomes | |
| tmp_5_3272644_G_C | 193 | E>D | No | 1000Genomes | |
| ENSVATH10681403 | 256 | S>G | No | 1000Genomes | |
| tmp_5_3272849_C_T | 262 | L>F | No | 1000Genomes | |
| ENSVATH10681404 | 263 | V>E | No | 1000Genomes | |
| ENSVATH00614850 | 281 | D>E | No | 1000Genomes | |
| ENSVATH06948092 | 286 | L>V | No | 1000Genomes | |
| ENSVATH06948093 | 303 | I>V | No | 1000Genomes | |
| ENSVATH06948094 | 305 | L>F | No | 1000Genomes | |
| tmp_5_3272997_C_G | 311 | T>S | No | 1000Genomes | |
| tmp_5_3273000_C_G | 312 | T>R | No | 1000Genomes | |
| ENSVATH00614851 | 314 | K>E | No | 1000Genomes | |
| tmp_5_3273024_T_A | 320 | I>N | No | 1000Genomes | |
| ENSVATH06948096 | 336 | S>T | No | 1000Genomes | |
| tmp_5_3273080_T_G | 339 | F>G | No | 1000Genomes |
No associated diseases with Q8H0W9
No regional properties for Q8H0W9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8H0W9 | |||
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| clathrin-coated pit | A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes. |
| clathrin-coated vesicle | A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-phosphatidylinositol binding | Binding to a phosphatidylinositol, a glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. |
| clathrin heavy chain binding | Binding to a clathrin heavy chain. |
| phosphatidylinositol-4,5-bisphosphate binding | Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. |
| SNARE binding | Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| clathrin coat assembly | The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage. |
| clathrin-dependent endocytosis | An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles. |
| vesicle budding from membrane | The evagination of a membrane, resulting in formation of a vesicle. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9SA65 | At1g03050 | Putative clathrin assembly protein At1g03050 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPGLKTHIIG | KFKDKASIGK | ARLVHSFGST | AVKYIHLALL | KSTTRTPNKP | PNSDYVSAVI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SYSNSRYAPA | AFSAALWRLR | VTKNAIVATK | SLIVIHKLIK | SSRDKFEGLG | HGRNNLKLNE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FSDKSSNLTL | ELSQWIRWYG | QYLDRLSWVP | KVLGSFPNLL | VNPKDKVEEK | DRVSSYQTGY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IIRQTDSLVS | FFEHICTRPE | IPPMFQNKIV | DEIRELVIED | YFKIVRLVMV | RLQVLFERLI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KPGVKPIGDL | GLNDFSLLLV | RLVECKESLS | GLFWRCRRLA | DDFWCLVEML | KAETEKKNNK |
| 310 | 320 | 330 | |||
| QMIELAGLVQ | TTVKDDEEMI | ELVGSVQPEW | VTFDDSDF |