Q8GZ42
PR
Gene name |
ATX5 (SDG29, SET29, At5g53430, MYN8.4) |
Protein name |
Histone-lysine N-methyltransferase ATX5 |
Names |
Protein SET DOMAIN GROUP 29, Trithorax-homolog protein 5, TRX-homolog protein 5 |
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G53430 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8GZ42
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8GZ42-F1 | Predicted | AlphaFoldDB |
71 variants for Q8GZ42
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH03420439 | 22 | I>R | No | 1000Genomes | |
| ENSVATH00731739 | 31 | L>F | No | 1000Genomes | |
| ENSVATH03420440 | 35 | G>S | No | 1000Genomes | |
| tmp_5_21677857_G_A | 79 | E>K | No | 1000Genomes | |
| ENSVATH07409085 | 82 | E>D | No | 1000Genomes | |
| tmp_5_21677909_C_T | 96 | P>L | No | 1000Genomes | |
| ENSVATH00731740 | 100 | K>R | No | 1000Genomes | |
| ENSVATH12737469 | 118 | I>V | No | 1000Genomes | |
| ENSVATH03420442 | 125 | N>S | No | 1000Genomes | |
| ENSVATH07409087 | 142 | R>S | No | 1000Genomes | |
| tmp_5_21678073_A_T | 151 | N>Y | No | 1000Genomes | |
| ENSVATH03420443 | 159 | Q>H | No | 1000Genomes | |
| ENSVATH12737470 | 159 | Q>P | No | 1000Genomes | |
| ENSVATH03420444 | 161 | T>A | No | 1000Genomes | |
| tmp_5_21678142_A_G | 174 | S>G | No | 1000Genomes | |
| tmp_5_21678194_G_A | 191 | R>K | No | 1000Genomes | |
| ENSVATH12737472 | 194 | N>H | No | 1000Genomes | |
| ENSVATH07409088 | 206 | D>G | No | 1000Genomes | |
| tmp_5_21678248_G_C | 209 | R>P | No | 1000Genomes | |
| ENSVATH12737474 | 214 | G>V | No | 1000Genomes | |
| ENSVATH03420445 | 227 | V>I | No | 1000Genomes | |
| tmp_5_21678374_A_T | 251 | E>V | No | 1000Genomes | |
| tmp_5_21678440_A_T,G | 273 | E>G | No | 1000Genomes | |
| tmp_5_21678439_G_A | 273 | E>K | No | 1000Genomes | |
| tmp_5_21678440_A_T,G | 273 | E>V | No | 1000Genomes | |
| ENSVATH03420446 | 282 | R>K | No | 1000Genomes | |
| ENSVATH00731744 | 294 | E>D | No | 1000Genomes | |
| ENSVATH00731746 | 296 | L>F | No | 1000Genomes | |
| ENSVATH12737488 | 304 | G>R | No | 1000Genomes | |
| ENSVATH07409099 | 307 | P>S | No | 1000Genomes | |
| tmp_5_21678711_A_G | 308 | R>G | No | 1000Genomes | |
| ENSVATH00731747 | 338 | N>S | No | 1000Genomes | |
| ENSVATH08573170 | 355 | S>W | No | 1000Genomes | |
| tmp_5_21678859_A_G | 357 | Q>R | No | 1000Genomes | |
| ENSVATH07409100 | 365 | S>N | No | 1000Genomes | |
| ENSVATH12737520 | 368 | M>L | No | 1000Genomes | |
| ENSVATH03420453 | 383 | V>I | No | 1000Genomes | |
| ENSVATH03420454 | 386 | F>L | No | 1000Genomes | |
| ENSVATH12737521 | 388 | M>I | No | 1000Genomes | |
| tmp_5_21679071_G_A | 398 | G>R | No | 1000Genomes | |
| ENSVATH00731750 | 404 | Q>K | No | 1000Genomes | |
| tmp_5_21679188_C_G | 412 | P>R | No | 1000Genomes | |
| ENSVATH07409108 | 437 | C>S | No | 1000Genomes | |
| tmp_5_21679530_C_G | 466 | C>W | No | 1000Genomes | |
| tmp_5_21679570_C_G | 480 | P>A | No | 1000Genomes | |
| ENSVATH00731756 | 480 | P>Q | No | 1000Genomes | |
| ENSVATH07409111 | 484 | S>F | No | 1000Genomes | |
| ENSVATH00731759 | 511 | F>I | No | 1000Genomes | |
| tmp_5_21679950_C_T | 531 | L>F | No | 1000Genomes | |
| ENSVATH14630100 | 531 | L>P | No | 1000Genomes | |
| tmp_5_21679984_C_A | 542 | A>E | No | 1000Genomes | |
| tmp_5_21680172_T_G | 571 | N>K | No | 1000Genomes | |
| ENSVATH07409117 | 575 | A>V | No | 1000Genomes | |
| tmp_5_21680191_C_A | 578 | P>T | No | 1000Genomes | |
| tmp_5_21680338_A_C | 596 | E>A | No | 1000Genomes | |
| tmp_5_21680350_C_T | 600 | P>L | No | 1000Genomes | |
| ENSVATH00731767 | 604 | K>N | No | 1000Genomes | |
| tmp_5_21680779_C_T | 654 | A>V | No | 1000Genomes | |
| tmp_5_21681153_A_C | 700 | E>D | No | 1000Genomes | |
| tmp_5_21681725_C_A | 777 | A>D | No | 1000Genomes | |
| ENSVATH00731779 | 805 | S>T | No | 1000Genomes | |
| ENSVATH00731780 | 820 | S>F | No | 1000Genomes | |
| ENSVATH03420527 | 827 | P>A | No | 1000Genomes | |
| ENSVATH03420528 | 827 | P>L | No | 1000Genomes | |
| tmp_5_21681919_A_G | 842 | T>A | No | 1000Genomes | |
| ENSVATH00731783 | 866 | S>Y | No | 1000Genomes | |
| ENSVATH14630109 | 875 | F>L | No | 1000Genomes | |
| ENSVATH03420538 | 883 | K>I | No | 1000Genomes | |
| ENSVATH07409153 | 1005 | T>I | No | 1000Genomes | |
| tmp_5_21682968_C_T | 1006 | T>I | No | 1000Genomes | |
| tmp_5_21683141_C_T | 1036 | P>L | No | 1000Genomes |
No associated diseases with Q8GZ42
12 regional properties for Q8GZ42
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PWWP domain | 223 - 318 | IPR000313 |
| domain | SET domain | 901 - 1024 | IPR001214 |
| domain | Zinc finger, PHD-type | 415 - 467 | IPR001965-1 |
| domain | Zinc finger, PHD-type | 609 - 656 | IPR001965-2 |
| domain | Zinc finger, PHD-type | 720 - 776 | IPR001965-3 |
| domain | Post-SET domain | 1027 - 1043 | IPR003616 |
| conserved_site | Zinc finger, PHD-type, conserved site | 610 - 655 | IPR019786 |
| domain | Zinc finger, PHD-finger | 413 - 469 | IPR019787-1 |
| domain | Zinc finger, PHD-finger | 607 - 658 | IPR019787-2 |
| domain | Extended PHD (ePHD) domain | 661 - 776 | IPR034732 |
| domain | ATX3/4/5, ePHD domain | 664 - 775 | IPR041955 |
| domain | ATX3/4/5, PHD domain | 609 - 655 | IPR042011 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| Ino80 complex | A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity. |
| plasmodesma | A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. |
| Set1C/COMPASS complex | A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| histone-lysine N-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. |
| metal ion binding | Binding to a metal ion. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin organization | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. |
| DNA-mediated transformation | The direct uptake and incorporation of exogenous genetic material (DNA or RNA) into a cell from its surroundings through the cell envelope. |
| positive regulation of histone H3-K4 methylation | Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 4 of histone H3. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIIKRKLKTL | KRCNSTNEED | DIVRKKRKVN | LNGGGSGGDY | YYPLNLLGEI | GAGIVPGKNG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FSVSLCKQVS | CSPKVEVVEE | EEEEEEIKST | RLVSRPPLVK | TSRGRVQVLP | SRFNDSVIEN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| WRKDNKSSGE | EREEEIEEEA | CRKEKVKVSS | NHSLKIKQQE | TKFTPRNYKY | SSSSALCGEI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DDEDKCEEIV | RYGNSFEMKK | QRYVDDEPRP | KKEGVYGPED | FYSGDLVWGK | SGRNEPFWPA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IVIDPMTQAP | ELVLRSCIPD | AACVMFFGHS | GTENERDYAW | VRRGMIFPFV | DYVERLQEQS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ELRGCNPRDF | QMALEEALLA | DQGFTEKLMQ | DIHMAAGNQT | FDDSVYRWVE | EAAGSSQYLD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HVAPSQDMKK | YRNPRACVGC | GMVLSFKMAQ | KMKALIPGDQ | LLCQPCSKLT | KPKHVCGICK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RIWNHLDSQS | WVRCDGCKVW | IHSACDQISH | KHFKDLGETD | YYCPTCRTKF | DFELSDSEKP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DSKSKLGKNN | APMVLPDKVI | VVCSGVEGIY | FPSLHLVVCK | CGSCGPERKA | LSEWERHTGS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KAKNWRTSVK | VKSSKLPLEE | WMMKLAEFHA | NATAAKPPKR | PSIKQRKQRL | LSFLREKYEP |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VNVKWTTERC | AVCRWVEDWD | YNKIIICNRC | QIAVHQECYG | TRNVRDFTSW | VCKACETPEI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KRECCLCPVK | GGALKPTDVE | TLWVHVTCAW | FQPEVCFASE | EKMEPALGIL | SIPSSNFVKI |
| 730 | 740 | 750 | 760 | 770 | 780 |
| CVICKQIHGS | CTQCCKCSTY | YHAMCASRAG | YRMELHCLEK | NGRQITKMVS | YCSYHRAPNP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DTVLIIQTPS | GVFSAKSLVQ | NKKKSGTRLI | LANREEIEES | AAEDTIPIDP | FSSARCRLYK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| RTVNSKKRTK | EEGIPHYTGG | LRHHPSAAIQ | TLNAFRHVAE | EPKSFSSFRE | RLHHLQRTEM |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ERVCFGRSGI | HGWGLFARRN | IQEGEMVLEY | RGEQVRGIIA | DLREARYRRE | GKDCYLFKIS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| EEVVVDATEK | GNIARLINHS | CMPNCYARIM | SVGDDESRIV | LIAKTTVASC | EELTYDYLFD |
| 1030 | 1040 | ||||
| PDEPDEFKVP | CLCKSPNCRK | FMN |