Q8CJ00
Gene name |
Noxa1 |
Protein name |
NADPH oxidase activator 1 |
Names |
|
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:241275 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
1-245 (TPR repeats and activation domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CJ00
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CJ00-F1 | Predicted | AlphaFoldDB |
34 variants for Q8CJ00
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388528197 | 3 | S>P | No | EVA | |
| rs3388534916 | 12 | H>Q | No | EVA | |
| rs3391389022 | 33 | V>A | No | EVA | |
| rs3388532993 | 36 | P>S | No | EVA | |
| rs3388531810 | 68 | D>E | No | EVA | |
| rs260510757 | 76 | L>F | No | EVA | |
| rs3388532583 | 78 | R>Q | No | EVA | |
| rs3388531839 | 84 | Q>H | No | EVA | |
| rs3388534394 | 87 | R>G | No | EVA | |
| rs237620504 | 100 | A>V | No | EVA | |
| rs3388532959 | 111 | T>I | No | EVA | |
| rs3388531390 | 128 | M>T | No | EVA | |
| rs3388531397 | 136 | G>W | No | EVA | |
| rs3388535391 | 141 | A>T | No | EVA | |
| rs215508214 | 155 | G>R | No | EVA | |
| rs27200598 | 185 | Q>H | No | EVA | |
| rs3388533763 | 191 | L>I | No | EVA | |
| rs3391113348 | 206 | V>G | No | EVA | |
| rs27200607 | 216 | A>V | No | EVA | |
| rs27200627 | 235 | M>T | No | EVA | |
| rs3388531385 | 245 | G>V | No | EVA | |
| rs253095005 | 259 | R>G | No | EVA | |
| rs3388535409 | 265 | P>S | No | EVA | |
| rs3413077234 | 271 | G>* | No | EVA | |
| rs27200630 | 276 | A>T | No | EVA | |
| rs3388528202 | 328 | A>D | No | EVA | |
| rs3388528163 | 333 | R>K | No | EVA | |
| rs3388533961 | 347 | I>M | No | EVA | |
| rs236858047 | 353 | V>M | No | EVA | |
| rs220691075 | 356 | G>R | No | EVA | |
| rs3388531816 | 363 | Q>K | No | EVA | |
| rs266152120 | 363 | Q>R | No | EVA | |
| rs240139238 | 365 | V>A | No | EVA | |
| rs3388528139 | 392 | Q>L | No | EVA |
No associated diseases with Q8CJ00
6 regional properties for Q8CJ00
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SH3 domain | 1 - 58 | IPR001452-1 |
| domain | SH3 domain | 98 - 157 | IPR001452-2 |
| domain | SH3 domain | 267 - 328 | IPR001452-3 |
| domain | SH3 domain-containing kinase-binding protein 1, first SH3 domain | 3 - 55 | IPR035770 |
| domain | SH3 domain-containing kinase-binding protein 1, second SH3 domain | 102 - 154 | IPR035771 |
| domain | SH3 domain-containing kinase-binding protein 1, third SH3 domain | 271 - 326 | IPR035772 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| NADPH oxidase complex | A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| SH3 domain binding | Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. |
| small GTPase binding | Binding to a small monomeric GTPase. |
| superoxide-generating NADPH oxidase activator activity | Binds to and increases the activity of the enzyme superoxide-generating NADPH oxidase. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of hydrogen peroxide metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide. |
| regulation of respiratory burst | Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. |
| superoxide anion generation | The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways. |
| superoxide metabolic process | The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O77775 | NCF2 | Neutrophil cytosol factor 2 | Bos taurus (Bovine) | PR |
| Q5HYK7 | SH3D19 | SH3 domain-containing protein 19 | Homo sapiens (Human) | PR |
| Q6XZF7 | DNMBP | Dynamin-binding protein | Homo sapiens (Human) | PR |
| P19878 | NCF2 | Neutrophil cytosol factor 2 | Homo sapiens (Human) | PR |
| Q86UR1 | NOXA1 | NADPH oxidase activator 1 | Homo sapiens (Human) | EV |
| O70145 | Ncf2 | Neutrophil cytosol factor 2 | Mus musculus (Mouse) | PR |
| A7E3N2 | Ncf2 | Neutrophil cytosol factor 2 | Rattus norvegicus (Rat) | PR |
| A7E3N7 | Noxa1 | NADPH oxidase activator 1 | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSLGDQIRD | WHRGVLAVAR | EDWDSALCFF | SDVREPLARM | YFNRGCVHLM | AGDPEAALRA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FDQAVTKDTC | MAVGFLQRGV | ANFQLQRFQE | AVSDFQLALA | QLRDNAVIDY | TQLGLNFKLQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AWEVLYNMAS | AQCQAGLWTK | AANTLVEAIS | KWPEGAQDIL | DIAMDKVQKQ | VPLQLQQVPK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GEVFQPPRRY | LKHLEPMDFL | GKAKVVASVI | PDDHNAQPQQ | RSQAEHAGHQ | PSSSMCKRVL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| STTGGHTSPG | LYDSLLASRR | PGPGPSEVSS | GSEGAATKDP | ESLVTVTVQC | HFTVPLKVPR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GTGLSSFQTL | LAQALLHQTQ | TGQLSYKAPG | EERSWIPIST | EESLQSIWRN | VPVGPGGLQL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QCQGVWGRPV | LYQVVAQYNY | RAQRPEDLDF | HQGDTVDVLC | EVDEAWLEGH | RDGCVGIFPK |
| 430 | 440 | ||||
| CFVVPAGAYV | EAMLVLGPQP | GDQN |