A7E3N7
Gene name |
Noxa1 |
Protein name |
NADPH oxidase activator 1 |
Names |
|
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:311793 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
1-244 (TPR repeats and activation domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A7E3N7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A7E3N7-F1 | Predicted | AlphaFoldDB |
No variants for A7E3N7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A7E3N7 | |||||
No associated diseases with A7E3N7
6 regional properties for A7E3N7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PB1 domain | 287 - 367 | IPR000270 |
| domain | SH3 domain | 371 - 430 | IPR001452 |
| repeat | Tetratricopeptide repeat | 38 - 71 | IPR019734-1 |
| repeat | Tetratricopeptide repeat | 72 - 105 | IPR019734-2 |
| repeat | Tetratricopeptide repeat | 122 - 155 | IPR019734-3 |
| domain | PB1-like domain | 287 - 367 | IPR053793 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| NADPH oxidase complex | A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| enzyme binding | Binding to an enzyme, a protein with catalytic activity. |
| SH3 domain binding | Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. |
| small GTPase binding | Binding to a small monomeric GTPase. |
| superoxide-generating NADPH oxidase activator activity | Binds to and increases the activity of the enzyme superoxide-generating NADPH oxidase. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of hydrogen peroxide metabolic process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide. |
| regulation of respiratory burst | Any process that modulates the rate frequency or extent of a phase of elevated metabolic activity, during which oxygen consumption increases; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals. |
| superoxide anion generation | The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways. |
| superoxide metabolic process | The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O77775 | NCF2 | Neutrophil cytosol factor 2 | Bos taurus (Bovine) | PR |
| Q5HYK7 | SH3D19 | SH3 domain-containing protein 19 | Homo sapiens (Human) | PR |
| Q6XZF7 | DNMBP | Dynamin-binding protein | Homo sapiens (Human) | PR |
| P19878 | NCF2 | Neutrophil cytosol factor 2 | Homo sapiens (Human) | PR |
| Q86UR1 | NOXA1 | NADPH oxidase activator 1 | Homo sapiens (Human) | EV |
| O70145 | Ncf2 | Neutrophil cytosol factor 2 | Mus musculus (Mouse) | PR |
| Q8CJ00 | Noxa1 | NADPH oxidase activator 1 | Mus musculus (Mouse) | SS |
| A7E3N2 | Ncf2 | Neutrophil cytosol factor 2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSLGDQIRD | WHRGVLAVAR | EDWDSALCFF | SDVREPLAKM | YFNMGCVHLM | AGDPEAALRA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FDQAVTKDTC | MAVGFLQRGV | ANFQLQRLQE | AVSDFQLALA | QLRGNAAIDY | TQLGLDFKLQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AWEVLYNMAS | VQCQAGLWTK | AANTLVEAIS | KRPEGAQDTL | EAAMDKVQKQ | VPLQLRQVPK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GEVFQPPRRY | LKHLEPMDFL | GKAKVVASVI | PDDHNSDIQP | QQSSQVEQAG | LQSSSPVCKR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VLSTRGGHMS | PGLWDSLLAT | GGPVPGPSED | SSSAEGTATK | DPESLVTVTV | QCHFTVPLKV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PRGTDLSSFR | TLLSQALLQQ | TQKGQFSYKA | RGEDRAWVPI | STEDSLQSVW | RNVPVSPRGL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QLQCRGAWGR | PVLYQVVAQY | DYRAQRPEDL | DFRQGDTVDV | LCEVDEAWLE | GHRDGRVGIF |
| 430 | 440 | ||||
| PKCFVVPAAT | CVEALPVPEP | QPGEQH |