Q8CIZ5

PR
Gene name
Dmbt1
Protein name
Deleted in malignant brain tumors 1 protein
Names
Ebnerin, Hensin, Pancrin
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:170568
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

20-89 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8CIZ5

Entry ID Method Resolution Chain Position Source
AF-Q8CIZ5-F1 Predicted AlphaFoldDB

No variants for Q8CIZ5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q8CIZ5

No associated diseases with Q8CIZ5

1 regional properties for Q8CIZ5

Type Name Position InterPro Accession
domain Heparinase II, N-terminal 150 - 314 IPR032518

Functions

Description
EC Number
Subcellular Localization
  • Secreted
  • Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass membrane protein ; Lumenal side
  • Localized to the lumenal aspect of crypt cells in the small intestine
  • In the colon, seen in the lumenal aspect of surface epithelial cells (By similarity)
  • Formed in the ducts of von Ebner gland and released into the fluid bathing the taste buds contained in the taste papillae
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

9 GO annotations of cellular component

Name Definition
collagen-containing extracellular matrix An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular matrix A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
extrinsic component of membrane The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
phagocytic vesicle membrane The lipid bilayer surrounding a phagocytic vesicle.
transport vesicle membrane The lipid bilayer surrounding a transport vesicle.
zymogen granule membrane The lipid bilayer surrounding a zymogen granule.

3 GO annotations of molecular function

Name Definition
extracellular matrix binding Binding to a component of the extracellular matrix.
scavenger receptor activity Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
zymogen binding Binding to a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis.

15 GO annotations of biological process

Name Definition
blastocyst development The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
columnar/cuboidal epithelial cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.
defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
defense response to Gram-negative bacterium Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
defense response to Gram-positive bacterium Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
detection of bacterial lipoprotein The series of events in which a bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Bacterial lipoproteins are lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs).
inner cell mass cell proliferation The proliferation of cells in the inner cell mass.
positive regulation of epithelial cell differentiation Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
response to bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
response to estrogen Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.
response to organic substance Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
response to wounding Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
tissue regeneration The regrowth of lost or destroyed tissues.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UGM3 DMBT1 Deleted in malignant brain tumors 1 protein Homo sapiens (Human) PR
Q4A3R3 DMBT1 Deleted in malignant brain tumors 1 protein Sus scrofa (Pig) PR
10 20 30 40 50 60
MGISIVIFEI CLLWGQILST ASQSRSSTPD WWNHGGTIND VIYDTQETPE VTTTQVPDST
70 80 90 100 110 120
SIGTDSGLAV RLVNGGDRCR GRVEILYQGS WGTMCDDGTD SGLAVRLVNG GDRCRGRVEI
130 140 150 160 170 180
LYQGSWGTMC DDSWDINDAN VVCRQLGCGW ALSAPGSAQF GQGLGPIVLD DVACRGHEAY
190 200 210 220 230 240
LWSCSHRGWL SHNCGHQEDA GVICSDSQTS SPTPGWWNPG GTNNDVIYDT QETTETSQTS
250 260 270 280 290 300
SPTPDWWNHG GTINDVIYDT QETTEGTDSG LAVRLVNGGD RCRGRVEILY QGSWGTVCDD
310 320 330 340 350 360
SWDINDANVV CRQLGCGWAL SAPGSAQFGQ GSGSIVLDDV ACRGHEAYLW SCSHRGWLSH
370 380 390 400 410 420
NCGHQEDAGV ICSYSQTSSP TPDSQTSSPT PGWWNPGGTN NDVSYGPEQT TDATDSGLAV
430 440 450 460 470 480
RLVNGGDRCQ GRVEILYQGS WGTVCDDSWD TKDANVVCRQ LVCGWALSAP GSAHFGQGSG
490 500 510 520 530 540
SIVLDDVACT GHEAYLWSCS HRGWLSHNCG HHEDAGVICS DAQTQSTTWP DMWPTTTPET
550 560 570 580 590 600
TTDWWTTKYS SSVPTTQFPT IADWWTTPSP EYTCGGLLTL PYGQFSSPYY PGSYPNNARC
610 620 630 640 650 660
LWKIFVSSMN RVTVVFTDVQ LEGGCNYDYI LVFDGPENNS SLIARVCDGF NGSFTSTQNF
670 680 690 700 710 720
MSVVFITDGS VTRRGFQADY YSTPISTSTT SPTTFPIVTD WWTTPSPEYT CGGLLTLPYG
730 740 750 760 770 780
QFSSPYYPGS YPNNARCLWK IFVPSMNRVT VVFTDVQLEG GCNYDYILGF DGPEYNSSLI
790 800 810 820 830 840
ARVCDGSNGS FTSTQNFMSV VFITDGSVTR RGFQADYYST PIRTSTTPPT TFPIITGNDS
850 860 870 880 890 900
SLVLRLVNGT NRCEGRVEIL YRGSWVPCAD DSWDINDANV VCRQLGCGSA LSAPGNAWFG
910 920 930 940 950 960
QGSGLIVLDD VSCSGYESHL WNCRHPGWLV HNCRHVEDAG VICSLPDPTP SPGPVWTSPP
970 980 990 1000 1010 1020
FVNYTCGGFL TGLSGQFSSP YYPGSYPNNA RCLWNIEVPN NYRVTVVFRD VQLEGGCNYD
1030 1040 1050 1060 1070 1080
YIEIFDGPHH SSPLIARVCD GAMGSFTSTS NFMSVRFTTD HSVTRRGFRA DYYSDFDNNT
1090 1100 1110 1120 1130 1140
TNLLCLSNHM RASVSRSYLQ SMGYSSRDLV IPGWNVSYQC QPQITQREVI FTIPYTGCGT
1150 1160 1170 1180 1190 1200
TKQADNETIN YSNFLKAAVS NGIIKRRKDL HIHVSCKMLQ NTWVNTMYIT NNTVEIQEVQ
1210 1220 1230 1240 1250 1260
YGNFDVNISF YTSSSFLYPV TSSPYYVDLD QNLYLQAEVL HSDTSLALFV DTCVASPHPN
1270 1280 1290 1300 1310 1320
DFSSLTYDLI RSGCIRDETY QSYSSPSPRI TRFKFSSFHF LNRFPSVYLQ CKLVVCRAND
1330 1340 1350 1360 1370 1380
VSSRCYRGCV VRSKRDVGSY QEKVDVVLGP IQLQSPSKEK RSLDLAVADV EKPASSQEVY
1390 1400 1410
PTAAIFGGVF LALVVAVAAF TLGRKTRTAR GQPPSTKM