Q4A3R3

PR
Gene name
DMBT1
Protein name
Deleted in malignant brain tumors 1 protein
Names
Hensin
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:751862
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-77 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q4A3R3

Entry ID Method Resolution Chain Position Source
AF-Q4A3R3-F1 Predicted AlphaFoldDB

No variants for Q4A3R3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q4A3R3

No associated diseases with Q4A3R3

12 regional properties for Q4A3R3

Type Name Position InterPro Accession
domain CUB domain 517 - 628 IPR000859-1
domain CUB domain 752 - 861 IPR000859-2
domain SRCR domain 84 - 184 IPR001190-1
domain SRCR domain 232 - 332 IPR001190-2
domain SRCR domain 380 - 480 IPR001190-3
domain SRCR domain 634 - 737 IPR001190-4
domain Zona pellucida domain 870 - 1118 IPR001507
domain SRCR-like domain 84 - 184 IPR017448-1
domain SRCR-like domain 232 - 332 IPR017448-2
domain SRCR-like domain 380 - 480 IPR017448-3
domain SRCR-like domain 634 - 737 IPR017448-4
conserved_site Zona pellucida domain, conserved site 1020 - 1060 IPR017977

Functions

Description
EC Number
Subcellular Localization
  • Secreted
  • Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass membrane protein ; Lumenal side
  • Localized to the lumenal aspect of crypt cells in the small intestine
  • In the colon, seen in the lumenal aspect of surface epithelial cells (By similarity)
  • Formed in the ducts of von Ebner gland and released into the fluid bathing the taste buds contained in the taste papillae (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
extrinsic component of membrane The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
transport vesicle membrane The lipid bilayer surrounding a transport vesicle.
zymogen granule membrane The lipid bilayer surrounding a zymogen granule.

3 GO annotations of molecular function

Name Definition
scavenger receptor activity Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs).
serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
zymogen binding Binding to a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis.

5 GO annotations of biological process

Name Definition
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
defense response to Gram-negative bacterium Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
defense response to Gram-positive bacterium Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
zymogen activation The proteolytic processing of an inactive enzyme to an active form.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8CIZ5 Dmbt1 Deleted in malignant brain tumors 1 protein Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MGTSAVILEI CLLLSQVLTT VSSTTQTEST TEDRTQITET AFWETQTINS VSESDLPGTH
70 80 90 100 110 120
ASSFHTEEPL TTIAAEGTEW DLALRLVNGG DRCQGRVEIL YQGSWGTVCD DSWDTNDANV
130 140 150 160 170 180
VCRQLGCGWA VSAPGSARFG QGLGPILLDD LRCSGHETYL WSCPHSGWKT HNCGHQEDAG
190 200 210 220 230 240
VICSGAQRSS TVIPDWWYTT TRSQTAHIRS TIPAWWHPTT TTAARTEWDL ALRLVNGGDR
250 260 270 280 290 300
CQGRVEVLYQ GSWGTVCDDS WDTNDANVVC RQLGCGWAVS APGSARFGQG SGPILLDDLR
310 320 330 340 350 360
CSGHETYLWS CPHSGWNTHN CGHHEDAGVI CSDAQRSSTV IPDWWYTTTP SQTAHIRSTI
370 380 390 400 410 420
PAWWHPTTTT AARTEWDLAL RLVNGGDRCQ GRVEVLYQGS WGTVCDDSWD TNDANVVCRQ
430 440 450 460 470 480
LGCGWAVSAP GSARFGQGSG PILLDDLRCS GHETYLWSCP HSGWNTHNCG HHEDAGVICS
490 500 510 520 530 540
DAQRSSTVIP DWWYTTTPSQ TWWHPTTTTA ASPSSPCGGF LTSASGTFSS PSYPGLYPNN
550 560 570 580 590 600
ANCVWEIEVN SGYRINLGFN NLQLEVHINC IYDYIEIFDE SPGSNTSLGK ICNHTSQIFT
610 620 630 640 650 660
SSYNRMTVRF RSDGSVQKPG FSAWYNSFPR DASLRLVNSN SSYPSCAGRV EIYQGGRWGT
670 680 690 700 710 720
VCDDGWDIQD AQVVCRQLGC GNAVSAPGNA YFGPGSGPIT LDDVACSGTE STLWQCRNRG
730 740 750 760 770 780
WFSHNCGHSE DAGVICSVPA FTTTPPATNY SCGGFLSQAA GGFNSPFYPG NYPNNANCVW
790 800 810 820 830 840
DIEVQNNYRV TVVFRDVQLE SGCNFDYIEV FDGPYRSSPL LARVCNGASG SFTSSSNFMS
850 860 870 880 890 900
IRFISDVSVT RAGFRANYYS SPSSGSTRLH CLQNHMQASV STSYLQSLGY SARDLVIPGW
910 920 930 940 950 960
EWSYQCQPQI TSTQVTFTIP YSSCGTIQRV DNDTITYSNS LRAAVSSGII KRKKDLNMYV
970 980 990 1000 1010 1020
SCRMLQNTWV NTVYIANDTL EVQNVQYGNF DVNISFFTSS SFLYPVRSSP YYVDLNQNLY
1030 1040 1050 1060 1070 1080
LQAELLHANA SLALFVDTCV ASPYPNDFTT LTYDLIRSGC VKDETYQSYS QPSPRIVRFK
1090 1100 1110 1120 1130 1140
FSSFHFLSRF PSVYLQCKMV VCRAFDSSSR CRRGCVVRSK RDVGSYQEKV DVVLGPIQLQ
1150 1160 1170 1180 1190 1200
TLHAEKRSLD QPAVDLEEKA SAQGSYDGAA ISAGIFLVVV LAVAAFTLGR RGRAADGQPL
ISKT