Q8CI71

PR
Gene name
Vps50
Protein name
Syndetin
Names
Bcl2-like protein blm, Coiled-coil domain-containing protein 132, EARP/GARPII complex subunit VPS50
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:73288
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-75 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q8CI71

Entry ID Method Resolution Chain Position Source
AF-Q8CI71-F1 Predicted AlphaFoldDB

21 variants for Q8CI71

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388821442 11 Q>L No EVA
rs227293520 31 V>A No EVA
rs3388806749 61 Y>C No EVA
rs3388793344 168 I>M No EVA
rs3396326017 185 I>N No EVA
rs3388793369 209 A>T No EVA
rs3388806756 250 I>F No EVA
rs3388809363 309 Y>F No EVA
rs3388818152 319 D>N No EVA
rs3388814262 323 P>T No EVA
rs3388818143 343 M>V No EVA
rs214202044 369 A>V No EVA
rs32433626 423 M>I No EVA
rs3388818132 489 L>R No EVA
rs3388803861 492 S>C No EVA
rs13466405 511 V>M No EVA
rs3388813259 556 D>A No EVA
rs3388807884 629 K>E No EVA
rs3388781719 855 A>D No EVA
rs3388814282 903 V>G No EVA
rs3388798540 964 R>* No EVA

No associated diseases with Q8CI71

2 regional properties for Q8CI71

Type Name Position InterPro Accession
domain Syndetin, C-terminal 723 - 957 IPR019514
domain Vacuolar protein sorting-associated protein 54, N-terminal 54 - 345 IPR019515

Functions

Description
EC Number
Subcellular Localization
  • Recycling endosome
  • Membrane
  • Associates with membranes in an EIPR1-dependent manner
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
EARP complex A quatrefoil tethering complex required for endocytic recycling.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
recycling endosome An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.

1 GO annotations of molecular function

Name Definition
SNARE binding Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.

2 GO annotations of biological process

Name Definition
endocytic recycling The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96JG6 VPS50 Syndetin Homo sapiens (Human) PR
F1LSG8 Vps50 Syndetin Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MQKIKSLMTR QGLKSPPESL NDLGAFESLR VPGKEEFREL REQPSDPQAE QELINSIEQV
70 80 90 100 110 120
YFSADPFDIV KYELEKLPPV LNLQELEEYR DKLKQQQSAV SKKVADLILE KQPAYVKELE
130 140 150 160 170 180
RVTSLQTGLQ LAAVICTNGR RHLNIAKEGF TQASLGLLAN QRKRQLLIGL LKSLRTIKTL
190 200 210 220 230 240
QRTDIRLSEM LEEEDYPGAI QLCLECQKAA STFKHYSCIS ELNSKLQDTL EQIEEQLDVA
250 260 270 280 290 300
LSKICKNFDI NHYTKVQQAY RLLGKTQTAM DQLHMHFTQA IHNTVFQVVL GYVELCAGNT
310 320 330 340 350 360
DTKFQKLQYK DLCTHVTPDS YIPCLADLCK ALWEVMLSYY RTMEWHEKHD NEETAAAAEG
370 380 390 400 410 420
SNVMSTEEAT FDRGYVKKKL EHGLTRIWQD VQLKVKTYLL GTDLSIFKYD DFIFVLDIVS
430 440 450 460 470 480
RLMQVGEEFC GSKSEVLQES IRKQSVNYFK NHHRIRLDEL RMFLENETWE LCPVKSNFSI
490 500 510 520 530 540
LQLHEFKFLE QSRSPSVSPS KQPSATSSKP VTLFEQYCSG GNPFEIQADH KDEETEDVLA
550 560 570 580 590 600
SNGYESDEQE KSAYQDYDSD SDVPEELKRD YVDEQTGDVP VKSVSRETLK SRKKSDYSLN
610 620 630 640 650 660
KVNAPILTNT TLNVIRLVGK YMQMMNILKP IAFDVIHFMS QLFDYYLYAI YTFFGRNDSL
670 680 690 700 710 720
ESTGLGLSSS RLKTTLNRIQ ESLIDLEGSA DPTATLTAAE ERKEKVPSPH LNQLVILTSG
730 740 750 760 770 780
DTLYGLAERV VATESLVFLA EQFEFLQPHL DAVMPAVKKP FLQQFYSQTV STASELRKPI
790 800 810 820 830 840
YWIVAGKAID YEQMLLLMMN VKWDVKEIMS QHNIYVDALL KEFEQFNKRL NEVSKRVRIP
850 860 870 880 890 900
LPVSNILWEH CIRLANRTIV EGYANVKKCS NEGRALMQLD FQQFLMKLEK LTDIRPIPDK
910 920 930 940 950 960
EFVETYIKAY YLTENDMERW IKEHREYSTK QLTNLVNVCL GSHINKKARQ KLLAAIDEID
RPKR