F1LSG8

PR
Gene name
Vps50
Protein name
Syndetin
Names
Coiled-coil domain-containing protein 132, EARP/GARPII complex subunit VPS50
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:312083
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-74 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for F1LSG8

Entry ID Method Resolution Chain Position Source
AF-F1LSG8-F1 Predicted AlphaFoldDB

No variants for F1LSG8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for F1LSG8

No associated diseases with F1LSG8

2 regional properties for F1LSG8

Type Name Position InterPro Accession
domain Syndetin, C-terminal 723 - 957 IPR019514
domain Vacuolar protein sorting-associated protein 54, N-terminal 54 - 345 IPR019515

Functions

Description
EC Number
Subcellular Localization
  • Recycling endosome
  • Membrane
  • Associates with membranes in an EIPR1-dependent manner
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
EARP complex A quatrefoil tethering complex required for endocytic recycling.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
recycling endosome An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.

1 GO annotations of molecular function

Name Definition
SNARE binding Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.

2 GO annotations of biological process

Name Definition
endocytic recycling The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96JG6 VPS50 Syndetin Homo sapiens (Human) PR
Q8CI71 Vps50 Syndetin Mus musculus (Mouse) PR
10 20 30 40 50 60
MQKIKSLMTR QGLKSPPESL NDLGAFESLR VPGKEEFREL REQPSDPQAE QELINSIEQV
70 80 90 100 110 120
YFSADPFDIV KYELEKLPPV LNLQELEEYR DKLKQQQAAV SKKVADLILE KQPAYVKELE
130 140 150 160 170 180
RVTSLQTGLQ LAAVICTNSR RHLNIAKEGF TQASLGLLAN QRKRQLLIGL LKSLRTIKTL
190 200 210 220 230 240
QRTDVRLSEM LEEEDYPGAI QLCLECQKAA STFKHYSCIS ELNSKLQDTL EQIEEQLDVA
250 260 270 280 290 300
LSKICKNFDV NHYTKVQQAY RLLGKTQTAM DQLHMHFTQA IHNTVFQVVL GYVELCAGNT
310 320 330 340 350 360
DTKFQKLQYK DLCTHVTPDS YIPCLADLCK ALWEVMLSYY RTMEWHEKHD SEETAAASEG
370 380 390 400 410 420
SNVMSTEETN FDRGYVKKKL EHGLTRIWQD VQLKVKTYLL GTDLSIFKYD DFIFVLDIVS
430 440 450 460 470 480
RLMQVGEEFC GSKSEVLQES IRKQSINYFK NHHRIRLDEL RMFLENETWE LCPVKSNFSI
490 500 510 520 530 540
LQLHEFKFLE QSRSPSVSPS KQPSATSSKP VTLFEQYCSG GNPFEIQADH KDEETEDVLA
550 560 570 580 590 600
SNGYESDEQE KSAYQDYDSD SDVPEELKRD YVDEQTGDVP VKSVSRETLK SRKKSDYSLN
610 620 630 640 650 660
KVNAPILTNT TLNVIRLVGK YMQMMNILKP IAFDVIHFMS QLFDYYLYAI YTFFGRNDSL
670 680 690 700 710 720
ESTGLGLSSS RLRTTLNRIQ ESLIDLEGSA DPTATLTAAE ERKEKVPSPH LNQLVILTSG
730 740 750 760 770 780
DTLYGLAERV VATESLVFLA EQFEFLQPHL DAVMPAVKKP FLQQFYSQTV STASELRKPI
790 800 810 820 830 840
YWIVAGKAID YEQMLLLMTN VKWDVKEIMS QHNVYVDALL KEFEQFNKRL NEVSKRVRIP
850 860 870 880 890 900
LPVSNILWEH CIRLANRTIV EGYANVKKCS NEGRALMQLD FQQFLMKLEK LTDIRPIPDK
910 920 930 940 950 960
EFVEIYIKAY YLTENDMERW IKEHREYSTK QLTNLVNVCL GSHINKKARQ KLLAAIDDID
RPKR