Q8CHX6
Gene name |
Mbtps2 |
Protein name |
Membrane-bound transcription factor site-2 protease |
Names |
Endopeptidase S2P |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:270669 |
EC number |
3.4.24.85: Metalloendopeptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CHX6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CHX6-F1 | Predicted | AlphaFoldDB |
29 variants for Q8CHX6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389581334 | 17 | V>L | No | EVA | |
| rs3389581800 | 18 | Y>C | No | EVA | |
| rs3389489203 | 96 | K>I | No | EVA | |
| rs3389574054 | 115 | S>Y | No | EVA | |
| rs3389584492 | 117 | S>P | No | EVA | |
| rs3389588677 | 118 | S>P | No | EVA | |
| rs3389577366 | 145 | G>S | No | EVA | |
| rs3389581751 | 159 | A>E | No | EVA | |
| rs3412259955 | 177 | R>S* | No | EVA | |
| rs16802174 | 189 | L>F | No | EVA | |
| rs3389560003 | 221 | I>K | No | EVA | |
| rs3412565663 | 244 | P>A | No | EVA | |
| rs3389592891 | 253 | L>H | No | EVA | |
| rs3412565597 | 256 | E>V | No | EVA | |
| rs3412825902 | 279 | Q>H* | No | EVA | |
| rs3412445940 | 281 | C>S | No | EVA | |
| rs3412445872 | 281 | C>Y | No | EVA | |
| rs3389489218 | 292 | C>S | No | EVA | |
| rs3389539072 | 371 | K>I | No | EVA | |
| rs16783928 | 376 | G>S | No | EVA | |
| rs3389559931 | 384 | V>I | No | EVA | |
| rs3389579670 | 398 | H>Y | No | EVA | |
| rs3412558533 | 401 | Q>P | No | EVA | |
| rs3412565624 | 431 | I>M | No | EVA | |
| rs3389581740 | 479 | V>L | No | EVA | |
| rs3389577417 | 488 | L>P | No | EVA | |
| rs3389577420 | 489 | I>V | No | EVA | |
| rs3389579696 | 501 | L>M | No | EVA | |
| rs3389581785 | 513 | T>R | No | EVA |
No associated diseases with Q8CHX6
No regional properties for Q8CHX6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q8CHX6 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.24.85 | Metalloendopeptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| metalloendopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| bone maturation | A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state. |
| cholesterol metabolic process | The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. |
| membrane protein intracellular domain proteolysis | The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain. |
| positive regulation of DNA-binding transcription factor activity | Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. |
| positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress. |
| regulation of response to endoplasmic reticulum stress | Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MIPVSLLVVV | VGGWTAVYLA | DLVLKSSVYF | KHSYEDWLEN | NGLSISPFHI | RWQTSIFNRA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FYSWGRRKAR | MLYQWFNFGM | VFGVIAMFSS | FFLLGKTLMQ | TLAQMMADSP | SPYSSSSSSS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SSSSSSSSSS | SSLHNEQVLQ | VVVPGINLPV | NQLTYFFAAV | LISGVVHEIG | HGIAAIREQV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RFNGFGIFLF | IIYPGAFVDL | FTTHLQLISP | VQQLRIFCAG | IWHNFVLALL | GILALVLLPV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ILLPFYYTGV | GVLITEVAED | SPAIGPRGLF | VGDLVTHLQD | CPVTNVQDWN | ECLDTIAYEP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QIGYCISAST | LQQLSFPVRA | YKRLDGSTEC | CNNHSLTDVC | FSYRNNFNKR | LHTCLPARKA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VEATQVCRSN | KDCKSGASSS | FCIVPSLETH | TRLIKVKHPP | QIDMLYVGHP | LHLHYTVSIT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SFIPRFNFLS | IDLPVIVETF | VKYLISLSGA | LAIVNAVPCF | ALDGQWILNS | FLDATLTSVI |
| 490 | 500 | 510 | |||
| GDNDVKDLIG | FFILLGGSVL | LAANVTLGLW | MVTAR |