Q0III2

PR
Gene name
MBTPS2
Protein name
Membrane-bound transcription factor site-2 protease
Names
Endopeptidase S2P
Species
Bos taurus (Bovine)
KEGG Pathway
bta:533134
EC number
3.4.24.85: Metalloendopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

76-162 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0III2

Entry ID Method Resolution Chain Position Source
AF-Q0III2-F1 Predicted AlphaFoldDB

109 variants for Q0III2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs453302162 4 V>G No EVA
rs136738413 8 V>G No EVA
rs464568453 9 V>G No EVA
rs136103722 11 V>G No EVA
rs482565562 13 G>V No EVA
rs448647498 18 Y>D No EVA
rs481629328 21 D>G No EVA
rs465032238 35 E>D No EVA
rs134932350 39 E>G No EVA
rs460780094 41 N>Y No EVA
rs448837832 52 W>S No EVA
rs478700861 54 T>S No EVA
rs438535925 55 A>G No EVA
rs471582119 59 R>C No EVA
rs443688987 63 S>G No EVA
rs443688987 63 S>R No EVA
rs454907331 66 R>P No EVA
rs472860264 71 M>I No EVA
rs467000627 75 W>C No EVA
rs478208885 76 F>L No EVA
rs445338071 76 F>V No EVA
rs450832112 78 F>L No EVA
rs462947337 78 F>V No EVA
rs480696665 80 M>I No EVA
rs440529885 81 V>G No EVA
rs462301648 81 V>L No EVA
rs475548927 84 V>A No EVA
rs475548927 84 V>E No EVA
rs475548927 84 V>G No EVA
rs439282607 84 V>L No EVA
rs435207148 86 A>S No EVA
rs434539976 87 M>I No EVA
rs474872911 87 M>L No EVA
rs453244050 87 M>R No EVA
rs464370054 88 F>V No EVA
rs445842503 91 F>S No EVA
rs433251582 92 F>V No EVA
rs468663626 95 G>R No EVA
rs480219398 108 D>A No EVA
rs480219398 108 D>V No EVA
rs458336958 111 Y>S No EVA
rs455474295 112 S>Y No EVA
rs463472396 115 S>F No EVA
rs474611004 118 S>P No EVA
rs441091725 119 S>P No EVA
rs1116140457 120 H>P No EVA
rs1116253137 120 H>Y No EVA
rs452258346 126 S>P No EVA
rs437000273 132 S>Y No EVA
rs457281962 134 L>R No EVA
rs468404013 135 Y>D No EVA
rs449884284 144 V>A No EVA
rs465059775 144 V>I No EVA
rs482773156 148 N>T No EVA
rs456078417 185 G>D No EVA
rs437513669 186 F>S No EVA
rs473815162 187 G>R No EVA
rs433845327 188 I>S No EVA
rs466847303 193 I>F No EVA
rs432952432 195 P>H No EVA
rs445024541 195 P>S No EVA
rs465426331 198 F>C No EVA
rs483226692 202 F>C No EVA
rs467769544 205 H>P No EVA
rs449224258 209 I>L No EVA
rs479323213 210 S>P No EVA
rs460703720 212 V>L No EVA
rs438913120 214 Q>E No EVA
rs465247380 224 H>Y No EVA
rs467606886 234 L>V No EVA
rs448592100 235 A>S No EVA
rs466149161 245 P>T No EVA
rs447603816 247 Y>F No EVA
rs459191077 248 Y>D No EVA
rs443958775 249 T>S No EVA
rs483024555 251 V>A No EVA
rs483024555 251 V>G No EVA
rs461407914 253 V>L No EVA
rs442465109 256 T>A No EVA
rs472122161 257 E>* No EVA
rs455499078 267 P>T No EVA
rs454141177 275 L>R No EVA
rs432487706 294 L>R No EVA
rs471838390 323 K>E No EVA
rs444544654 333 N>K No EVA
rs455606416 341 C>W No EVA
rs473979555 341 C>Y No EVA
rs380974152 351 R>H No EVA
rs448210616 393 R>G No EVA
rs482476875 421 T>I No EVA
rs464046249 423 F>C No EVA
rs475181205 428 K>M No EVA
rs453471636 433 D>G No EVA
rs470692661 434 L>Q No EVA
rs440852419 434 L>V No EVA
rs437330946 454 I>S No EVA
rs470141680 457 A>T No EVA
rs448511502 458 V>G No EVA
rs481718821 460 C>Y No EVA
rs460005187 466 Q>E No EVA
rs448004148 470 N>H No EVA
rs477651385 476 T>S No EVA
rs459172296 482 G>A No EVA
rs443268447 495 L>S No EVA
rs476136859 496 L>H No EVA
rs442387564 497 G>A No EVA
rs472273518 505 N>T No EVA
rs432287262 512 M>I No EVA
rs471561683 517 R>L No EVA

No associated diseases with Q0III2

1 regional properties for Q0III2

Type Name Position InterPro Accession
domain Zinc finger, Mcm10/DnaG-type 301 - 347 IPR015408

Functions

Description
EC Number 3.4.24.85 Metalloendopeptidases
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
  • Cytoplasm
  • Golgi apparatus membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

6 GO annotations of biological process

Name Definition
bone maturation A developmental process, independent of morphogenetic (shape) change, that is required for bone to attain its fully functional state.
cholesterol metabolic process The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
membrane protein intracellular domain proteolysis The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain.
positive regulation of DNA-binding transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress.
regulation of response to endoplasmic reticulum stress Any process that modulates the frequency, rate or extent of response to endoplasmic reticulum stress.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O43462 MBTPS2 Membrane-bound transcription factor site-2 protease Homo sapiens (Human) PR
Q8CHX6 Mbtps2 Membrane-bound transcription factor site-2 protease Mus musculus (Mouse) PR
10 20 30 40 50 60
MIPVSLVVVV VGGWTAVYLT DLVLKSSVYF KHSYEDWLEN NGLSISPFHI RWQTAVFNRA
70 80 90 100 110 120
FYSWGRRKAR MLYQWFNFGM VFGVIAMFSS FFLLGKTLIQ TLGQMMADSS YSSSSSSSSH
130 140 150 160 170 180
SSSSSSSSSS SSSLYNEQVL QVVVPGINLP VNQLTYFFAA VLISGVVHEI GHGIAAIREQ
190 200 210 220 230 240
VRFNGFGIFL FIIYPGAFVD LFTTHLQLIS PVQQLRIFCA GIWHNFILAL LGILALILLP
250 260 270 280 290 300
VILLPFYYTG VGVLITEVAE DSPAIGPRGL FVGDLVTHLQ DCPVTNVQDW NECLDTITYE
310 320 330 340 350 360
PQIGYCISAS TLQQLSFPVR AYKRLDGSTE CCNNHSLTDV CFSYRNNFNK RLHTCLPARK
370 380 390 400 410 420
AVEATQVCRT NKDCKKSSSS SFCIIPSLET HTRLIKVKHP PQIDMLYVGH PLHLHYTVSI
430 440 450 460 470 480
TSFIPRFKFL SIDLPVVVET FVKYLISLSG ALAIVNAVPC FALDGQWILN SFLDATLTSV
490 500 510
IGDNDVKDLI GFFILLGGSI LLAANVALGL WMVTAR