Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q8CH34
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q8CH34-F1 | Predicted | AlphaFoldDB |
No variants for Q8CH34
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q8CH34 | |||||
No associated diseases with Q8CH34
4 regional properties for Q8CH34
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| collagen-containing extracellular matrix | An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. |
| egg coat | A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| acrosin binding | Binding to acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities. |
| identical protein binding | Binding to an identical protein or proteins. |
| structural constituent of egg coat | The action of a molecule that contributes to the structural integrity of an egg coat. An egg coat is a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| acrosomal vesicle exocytosis | The calcium ion regulated exocytosis which results in fusion of the acrosomal vesicle with the plasma membrane of the sperm as part of the acrosome reaction. |
| binding of sperm to zona pellucida | The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place. |
| negative regulation of binding of sperm to zona pellucida | Any process that stops, prevents or reduces the frequency, rate or extent of binding of sperm to the zona pellucida. |
| positive regulation of acrosome reaction | Any process that activates or increases the frequency, rate or extent of the acrosome reaction. |
| positive regulation of humoral immune response | Any process that activates or increases the frequency, rate, or extent of a humoral immune response. |
| positive regulation of T cell proliferation | Any process that activates or increases the rate or extent of T cell proliferation. |
| prevention of polyspermy | The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O54767 | Zp2 | Zona pellucida sperm-binding protein 2 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARQALRSTL | WLLPSILLCF | PFCLPLSGQH | VTELPGVLHC | GLQSFQFAVN | LSLEAESPVL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TTWDSQGLPH | RLKNDSDCGT | WVMDSPDGFL | VLEASYSGCY | VTLEGSHYIM | TVGVQEADVA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GHVAGTRQRL | LTCPLALQGK | APDTPNAKVC | SPVPVKERLP | CASSTISRGD | CEELGCCYSS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EEEGADSCYY | GNTVTSHCTK | EGHFSIAVSR | DVTSPPLRLD | SLRLGFRNIT | TGCDPVMKTS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TFVLFQFPLT | SCGTTQRITG | DQAMYENELV | AIRDVQAWGR | SSITRDSNFR | LRVSCTYSIH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SIMSPVNMQV | WTLPPPLPKT | QPGPLSLELQ | IAQDKNYSSY | YGTDAYPLVK | FLQDPIYVEV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SILHRTDPSL | SLLLEQCWAT | PGSNPFHQPQ | WPILVKGCPY | AGDNYQTKRI | PVQKASDVFP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SHHQRFSIST | FSFMSAGREK | QVLGGQVYLH | CSASVCQPAG | MPSCTVICPA | SRRRRKSELY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FDNSTSISSK | GPVILLQATK | DPAVMLHKHS | GTHADSPTLW | VMGLSASMVI | TGVLVVSYLA |
| TRKQR |