O54767
Gene name |
Zp2 (Zpa) |
Protein name |
Zona pellucida sperm-binding protein 2 |
Names |
Zona pellucida glycoprotein 2, Zp-2, Zona pellucida protein A |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:81828 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O54767
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O54767-F1 | Predicted | AlphaFoldDB |
No variants for O54767
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O54767 | |||||
No associated diseases with O54767
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| collagen-containing extracellular matrix | An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. |
| egg coat | A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| multivesicular body | A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| acrosin binding | Binding to acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities. |
| identical protein binding | Binding to an identical protein or proteins. |
| structural constituent of egg coat | The action of a molecule that contributes to the structural integrity of an egg coat. An egg coat is a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| binding of sperm to zona pellucida | The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place. |
| prevention of polyspermy | The negative regulation of fertilization process that takes place as part of egg activation, ensuring that only a single sperm fertilizes the egg. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8CH34 | Zp4 | Zona pellucida sperm-binding protein 4 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARWQRVYWL | RSLFFALVTS | VNSLSLPQSE | NPAFPGTLIC | DKDEVRVEFS | SRFDMEKWNP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SLVDTFGNEI | SNCTYALDLE | KFILKFPYET | CTIKVIGGYQ | VNIRVQDTNA | DVSYKDDVHH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FFCPAIQAEI | HEVSEIVVCM | EDLISFSFPQ | LFSRLADENQ | NVSEMGWIIK | IGNGTRVHTL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PLKDAIVQGF | NLLIDSQKIT | LHVPANATGV | AHYVQESSYL | YTVQLKLLFS | SPGQKITFSS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QAICAPDLSV | ACNVTHMSLT | IPEFPGKLKS | VGFGQRNIPE | DQWHANGIDK | EATNGLRLHF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RKSLLKTKPS | EKCPFYQFYF | SSLELTFNFQ | GDMLSTVIDP | ECHCESPVSI | DELCTRDGFM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DFEVYSHQTK | PALNLESLLV | GNSSCQPIFK | VQSLGLARFH | IPLNGCGTRQ | KFEGDKVIYE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| NEIHALWENP | PSNIIFRNSE | FRMTVRCHYI | RDSMLLRAHI | KSHSSPVASV | KPGPLALVLQ |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TYPDISYQRP | YRKNEYPLVR | YLRQPIYMEV | TVLNRNDPNI | KLVLDDCWAT | TFEDPASVPQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| WQIIMDGCEY | ELDNYRTTFH | AANSSAAHSG | HYQRFDVKTF | AFVSESRGLS | SLIYFHCSAL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ICNQASPLCS | VTCPAPLRNK | REASKEGTMT | VSLPGPIILL | SDDSSSKGVM | NPDSYEITKD |
| 670 | 680 | 690 | |||
| IASKTLGAVA | ALVGSAVIIG | FICYLHKKRI | VRFNS |