AiPD: Autoinhibited Protein Database

Gene name	Sugp1 (Sf4)
Protein name	SURP and G-patch domain-containing protein 1
Names	Splicing factor 4
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:70616
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

75-172 (Predicted disordered autoinhibitory region) PR

75-172 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
1UG0	NMR	-	A	165-239	PDB
1X4O	NMR	-	A	250-314	PDB
AF-Q8CH02-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388987762	74	H>R	No	EVA
rs3388991666	94	K>R	No	EVA
rs3388939026	96	Q>H	No	EVA
rs3411191482	149	P>H	No	EVA
rs3388939074	186	R>I	No	EVA
rs3388984646	250	K>E	No	EVA
rs3388973777	308	K>R	No	EVA
rs235285933	310	D>E	No	EVA
rs261919057	323	F>L	No	EVA
rs214626381	324	P>S	No	EVA
rs13471212	326	P>L	No	EVA
rs3388984715	335	K>N	No	EVA
rs3388984712	340	A>S	No	EVA
rs3399428795	392	V>M	No	EVA
rs3399254235	407	S>T	No	EVA
rs3388973702	427	V>M	No	EVA
rs3388939046	467	Q>H	No	EVA
rs3388969208	565	Y>*	No	EVA
rs3388979925	567	M>R	No	EVA
rs3399205547	611	S>*	No	EVA
rs3388984035	627	A>P	No	EVA

Type	Name	Position	InterPro Accession
domain	SWAP/Surp	185 - 239	IPR000061-1
domain	SWAP/Surp	260 - 314	IPR000061-2
domain	G-patch domain	558 - 607	IPR000467

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
spliceosomal complex	Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.

Name	Definition
RNA binding	Binding to an RNA molecule or a portion thereof.

Name	Definition
mRNA processing	Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
RNA splicing	The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q8IWZ8	SUGP1	SURP and G-patch domain-containing protein 1	Homo sapiens (Human)	PR