AiPD: Autoinhibited Protein Database

Gene name	Exd1 (Exdl1)
Protein name	piRNA biogenesis protein EXD1
Names	Exonuclease 3'-5' domain-containing protein 1, Exonuclease 3'-5' domain-like-containing protein 1, Inactive exonuclease EXD1, mExd1
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:241624
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

48-152 (Predicted disordered autoinhibitory region) PR

48-152 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q8CDF7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3391958714	32	Q>E	No	EVA
rs3388584461	79	G>R	No	EVA
rs3388573181	81	K>M	No	EVA
rs3388575969	85	V>I	No	EVA
rs248559656	89	T>A	No	EVA
rs3392099286	113	E>Q	No	EVA
rs3391968120	113	E>V	No	EVA
rs3388579837	132	E>G	No	EVA
rs3388573177	137	V>I	No	EVA
rs3388584439	149	M>V	No	EVA
rs3388574881	158	L>P	No	EVA
rs3392084764	192	L>M	No	EVA
rs3388575193	271	V>F	No	EVA
rs3388573180	305	I>V	No	EVA
rs3388580634	349	G>C	No	EVA
rs27455994	376	V>A	No	EVA
rs241483472	398	T>K	No	EVA
rs259398438	414	Y>C	No	EVA
rs45921287	429	K>E	No	EVA
rs47180696	432	E>K	No	EVA
rs3388576028	447	K>Q	No	EVA
rs230378243	458	E>K	No	EVA
rs27455996	460	H>L	No	EVA
rs27455996	460	H>R	No	EVA
rs249055090	461	K>E	No	EVA
rs3388583850	468	G>V	No	EVA
rs234212130	471	E>K	No	EVA
rs27455998	488	P>S	No	EVA
rs27455999	506	T>I	No	EVA
rs228647669	506	T>P	No	EVA
rs3388583863	507	V>L	No	EVA
rs3391968156	518	K>*	No	EVA
rs224040524	518	K>R	No	EVA
rs27456000	531	T>N	No	EVA
rs3388580984	538	T>A	No	EVA
rs243082071	544	K>N	No	EVA
rs223154072	545	A>V	No	EVA

Type	Name	Position	InterPro Accession
domain	3'-5' exonuclease domain	134 - 325	IPR002562

		Description
EC Number
Subcellular Localization	Cytoplasm	Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
P granule	A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes.
PET complex	A protein complex that is composed of at least EXD1, TDRD12 and some PIWI protein. The complex is required for MILI slicing-triggered biogenesis and loading of MIWI2 piRNAs.

Name	Definition
protein homodimerization activity	Binding to an identical protein to form a homodimer.
RNA binding	Binding to an RNA molecule or a portion thereof.

Name	Definition
gene silencing by RNA	A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation.
meiotic cell cycle	Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
piRNA metabolic process	The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q0P3U3	exd1	piRNA biogenesis protein EXD1	Danio rerio (Zebrafish) (Brachydanio rerio)	PR