Q0P3U3

PR
Gene name
exd1 (exdl1, zgc:154068)
Protein name
piRNA biogenesis protein EXD1
Names
Exonuclease 3'-5' domain-containing protein 1, Exonuclease 3'-5' domain-like-containing protein 1, Inactive exonuclease EXD1
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:751755
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q0P3U3

Entry ID Method Resolution Chain Position Source
AF-Q0P3U3-F1 Predicted AlphaFoldDB

No variants for Q0P3U3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q0P3U3

No associated diseases with Q0P3U3

1 regional properties for Q0P3U3

Type Name Position InterPro Accession
domain 3'-5' exonuclease domain 148 - 264 IPR002562

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
P granule A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes.
PET complex A protein complex that is composed of at least EXD1, TDRD12 and some PIWI protein. The complex is required for MILI slicing-triggered biogenesis and loading of MIWI2 piRNAs.

2 GO annotations of molecular function

Name Definition
protein homodimerization activity Binding to an identical protein to form a homodimer.
RNA binding Binding to an RNA molecule or a portion thereof.

3 GO annotations of biological process

Name Definition
gene silencing by RNA A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation.
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
piRNA metabolic process The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8CDF7 Exd1 piRNA biogenesis protein EXD1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MNNRLNTTSS SEESRFLEEM KRKRVNITLS DTEISGVIQK ITQKKTLILE DVSEVRSGRR
70 80 90 100 110 120
FPGAKLIFGK EIVKVEFPLS AGQASVFSNE KHKSEFQTFK KKMTLDGEED GVSYVLIDEL
130 140 150 160 170 180
HEKFGPAVMH IQEQDVIGIG ADVYGQSGQE RLCWLQVATK KVVYLFDILL LGGPAFKNGL
190 200 210 220 230 240
SMILENTHIL KVLHDCRCIT RCLRTEFRVQ LTNVFDTQVA ELLLFFNESG GFLPDRPASL
250 260 270 280 290 300
PELLQLHLRL TTAEIQPLCS KQQQSRECVQ LWYVRPCPPD LLSLMCSSVQ HLLSLRLLLL
310 320 330 340 350 360
DALLADYTVL VDSFMSSSHC PPLHFQQDEC AVPPELQELM CVRQQRMDWA SQCYSQTDSG
370
LLQRSSFKAS PHTPADAQ